VMED 5244 - EVBM Final
Review
1. How can you determine the mechanism of icterus (pre-hepatic, hepatic or post-hepatic)?:
Moderate or marked decrease in hematocrit? (usually regenera- tive)
+/- spherocytes
+/- auto-agglutination
+/- positive Coombs test
+/- hemoglobinemia and hemoglobinuria
= Pre-hepatic (hemolysis)
Normal or mild decrease in hematocrit? (usually non-regenerative)
- ALT/AST v. increased
- ALP/GGT increased
- Alb chol, gluc, urea decreased
= Hepatic
- ALT/AST increased
- ALP/GGT v. increased
- Cholesterol increased
- Alb, gluc, urea = WNL
= Post-hepatic
, VMED 5244 - EVBM Final
Review
2. What are potential prehepatic causes of hyperbilirubinemia in cats?: - My- coplasma spp
- Cytauxzoon felis
- FIP
- Babesia spp.
- FeLV
- FIV
- IMHA
- Neonatal isoerythrolysis
- Transfusion reaction
3. FeLV-associated diseases?: Hematologic disorders
• FeLV used to be the most common cause of non-regenerative anemia, not the case any more due to
decrease in overall FeLV prevalence.
• Pure red cell aplasia
• 10% of FeLV-associated anemias are regenerative
• Immune-mediated hemolytic anemia
• Co-infection with hemotropic mycoplasma
• Immune-mediated thrombocytopenia
, VMED 5244 - EVBM Final
Review
• Neutropenia
• Myelodysplasia
Immunosuppression and secondary infections
Neurological disease, stomatitis, etc.
4. Causes of hemotropic mycoplasmosis?: Mycoplasma haemofelis, "Candida- tus Mycoplasma
haemominutum," and "Candidatus Mycoplasma turicensis"
5. Primary MOT of hemotropic mycoplasmosis?: Uncertain. Biting or aggressive interactions are a
suspected mode
6. C/S of hemotropic mycoplasmosis?: Fever, lethargy, inappetence, weakness, pallor, and
dehydration.
7. Diagnosis of hemotropic mycoplasmosis?: PCR
8. C/S of Cytauxzoon felis?: •anorexia, lethargy or depressed mentation,
• elevation of the third eyelid,
• vocalization,
, VMED 5244 - EVBM Final
Review
• increased respiratory effort,
• icterus, pallor,
• lymphadenomegaly, splenomegaly or hepatomegaly,
• sometimes seizures
9. Organ systems that can cause acute onset vomiting, anorexia, and lethar- gy?: - GI
- Pancreas
- Liver
- Other organ systems ("metabolic")
10.What is considered hypoglycemia?: BG < 60 -80 mg/dl
- Non-veterinary glucometers often under-estimate
11.How is the brain impacted by hypoglycemia?: • Glu enters the cells via diffusion
• NOT insulin-dependent
• “BG ’ “ ATP ’ neuronal death ’ cortex
12.C/S associated with hypoglycemia?: • Lethargy, weakness, blindness, ataxia, seizures, coma
• Severity related to chronicity
Review
1. How can you determine the mechanism of icterus (pre-hepatic, hepatic or post-hepatic)?:
Moderate or marked decrease in hematocrit? (usually regenera- tive)
+/- spherocytes
+/- auto-agglutination
+/- positive Coombs test
+/- hemoglobinemia and hemoglobinuria
= Pre-hepatic (hemolysis)
Normal or mild decrease in hematocrit? (usually non-regenerative)
- ALT/AST v. increased
- ALP/GGT increased
- Alb chol, gluc, urea decreased
= Hepatic
- ALT/AST increased
- ALP/GGT v. increased
- Cholesterol increased
- Alb, gluc, urea = WNL
= Post-hepatic
, VMED 5244 - EVBM Final
Review
2. What are potential prehepatic causes of hyperbilirubinemia in cats?: - My- coplasma spp
- Cytauxzoon felis
- FIP
- Babesia spp.
- FeLV
- FIV
- IMHA
- Neonatal isoerythrolysis
- Transfusion reaction
3. FeLV-associated diseases?: Hematologic disorders
• FeLV used to be the most common cause of non-regenerative anemia, not the case any more due to
decrease in overall FeLV prevalence.
• Pure red cell aplasia
• 10% of FeLV-associated anemias are regenerative
• Immune-mediated hemolytic anemia
• Co-infection with hemotropic mycoplasma
• Immune-mediated thrombocytopenia
, VMED 5244 - EVBM Final
Review
• Neutropenia
• Myelodysplasia
Immunosuppression and secondary infections
Neurological disease, stomatitis, etc.
4. Causes of hemotropic mycoplasmosis?: Mycoplasma haemofelis, "Candida- tus Mycoplasma
haemominutum," and "Candidatus Mycoplasma turicensis"
5. Primary MOT of hemotropic mycoplasmosis?: Uncertain. Biting or aggressive interactions are a
suspected mode
6. C/S of hemotropic mycoplasmosis?: Fever, lethargy, inappetence, weakness, pallor, and
dehydration.
7. Diagnosis of hemotropic mycoplasmosis?: PCR
8. C/S of Cytauxzoon felis?: •anorexia, lethargy or depressed mentation,
• elevation of the third eyelid,
• vocalization,
, VMED 5244 - EVBM Final
Review
• increased respiratory effort,
• icterus, pallor,
• lymphadenomegaly, splenomegaly or hepatomegaly,
• sometimes seizures
9. Organ systems that can cause acute onset vomiting, anorexia, and lethar- gy?: - GI
- Pancreas
- Liver
- Other organ systems ("metabolic")
10.What is considered hypoglycemia?: BG < 60 -80 mg/dl
- Non-veterinary glucometers often under-estimate
11.How is the brain impacted by hypoglycemia?: • Glu enters the cells via diffusion
• NOT insulin-dependent
• “BG ’ “ ATP ’ neuronal death ’ cortex
12.C/S associated with hypoglycemia?: • Lethargy, weakness, blindness, ataxia, seizures, coma
• Severity related to chronicity