NURS 5315 UTA EXAM 2|COMPLETE STUDY GUIDE WITH HIGH YIELD QUESTIONS AND 100% RIGHT/AUTHENTIC ANSWERS|GET A PASS ON YOUR FIRST TRIAL|LATEST UPDATED VERSION 2025

Arachidonic pathway purpose - CORRECT ANSWERS.️️Synthesis of prostaglandins Non-selective NSAIDS - CORRECT ANSWERS.️️Inhibit COX1 and COX2, risk for gastric ulceration, GI bleeds, edema, renal impairment ASA - CORRECT ANSWERS.️️Blocks COX1 and COX2, also inhibits Thromboxane A2 and prostaglandins Corticosteroids - CORRECT ANSWERS.️️Inhibit phospholipase A2, preventing formation of prostaglandins, thromboxane A2, prostacyclin, and leukotrines Thromboxane - CORRECT ANSWERS.️️Vasoconstriction, platelet aggregation Prostacyclin - CORRECT ANSWERS.️️Vasodilation, platelet aggregation (most effective one) Type 1 hypersensitivity - CORRECT ANSWERS.️️E. Immediate response to allergen, food, meds, pollen, asthma, allergic reactions P. IgE binds with antigen at 1st exposure. Antigen binds with this complex at 2nd exposure. Inflammatory cascade initiates. C.M. Urticaria, rhinitis, conjunctivitis, angioedema, anaphylaxis Atopic disorders - CORRECT ANSWERS.️️Genetic Type 1 hypersensitivity, asthma, hay fever, eczema, urticaria Type 2 hypersensitivity - CORRECT ANSWERS.️️E. Antibodies directed against fixed antigens on the plasma membrane of cells C.M. Varies depending on alloimmune or autoimmune Alloimmunity and example of hypersensitivity - CORRECT ANSWERS.️️When an individuals immune system reacts against antigens on the tissues of other members of the same species Blood transfusions- causes clumping and lysis of RBC- fever, nausea, chills, low back pain, dark urine, hives, itching, SOB Rh incompatibility- hemolytic disease of newborn with jaundice, give Rhogam within 72 hours of birth (Rh- mother with Rh+ child) Autoimmunity and example of hypersensitivity - CORRECT ANSWERS.️️A breakdown of tolerance in which the bodies immune system begins to recognize self-antigens as foreign. Graves Disease- autoantibodies form against thyroid cells- bind to thyroid cells and mimic action of TSH, increases secretion of thyroxine Myasthenia Gravis- autoantibodies against acetylcholine bind to the post synaptic receptors and inhibit synaptic transmission of acetylcholine. Leads to muscle weakness and paralysis (mind to ground) Guillain-Barre' syndrome- antibodies bind with myelin sheath of the peripheral nervous system, triggering the immune response. Causes demyelination of the peripheral nerves and a rapidly progressive, ascending paralysis (ground to brain) Type III hypersensitivity - CORRECT ANSWERS.️️Widespread immune and inflammatory response not specified for any cell or tissue. SLE, RA Antibodies are formed against and bind to circulating antigens, antigen-antibody complex deposits in vessel walls or tissue. Causes cellular and tissue damage. IgG and IgM response, spread via circulation- not specific to a cell or tissue- widespread damage. Type IV hypersensitivity - CORRECT ANSWERS.️️T-cell lymphocyte mediated reaction that does not require antibody activation. Delayed response- 24-72 hours. Contact dermatitis- poison ivy, topical drugs, chemicals such as nickel or formaldehyde. Antigens too small to cause a reaction bind to proteins, response includes rash, red bumps, itching, and blisters. Reactive tuberculin test- PPD cause and induration in 24-72 if person was previously exposed to tuberculin antigen Solid organ transplant rejection- 11-14 days after 1st exposure, 5-6 days after 2nd exposure, results in mononuclear infiltration, decreased circulation, and tissue necrosis. Systemic Lupus Erythematosus - CORRECT ANSWERS.️️E. Primarily women aged 20-40, Type III hypersensitivity. Antibodies are formed against DNA Genetic, leads to tissue damage. Exacerbated by infections, UV light, estrogen, meds, stress Diagnosed by serum ANA C.M. Butterfly rash (cheeks), photosensitivity, nonerosive arthritis of at least 2 peripheral joints, inflammation of serous sacs, proteinuria, seizures, anemia, leukopenia, thrombocytopenia