ANTICOAGULANTS
theththethe drugs that reduce the the coagulablity of the blood is called
"Anticoagulants".
HEPARIN:
It was discovered by Mclean in 1916. It was named 'heparin' as it was first extracted from liver .It is a
mucopolysaccharide found in the mast cells of the liver, lungs and industrial .
OTHER ACTION:
heparin activates lipoprotein lipase> hydrolysis triclycerides in the plasma> clearance of lipids in
plasma.
Mechanism of action:
molecular weight -10000 to 30000 heparin >binds and activates plasma antithrombin III (1000 folds
faster)> degrades thrombin and factors 10a 9a > prevents conversion of fibrinogen to fibrin >
Anticoagulant effect
Pharmacokinetics:
Route of administration : IV or SC
Dosage of action : peak in 5-10 mins returns to normal in 2-4 hours.
Metabolised by heparinase in liver.
Monitored by clotting time .
Dose and administration:
Bolus dose : 5000 IU
Maintenance dose : 1000-1500 IU
apTT : 1.5-2 times the control value
CT : 1.8 - 2.5 times then normal apTT
Prophylaxis dose:5000 IU SC every 8 to 12 hours.
Adverse effects:
bleeding
allergic reactions
hypersensitivity reactions
heparin induced thrombocytopenia
alopecia (hair loss) after 5 - 10 days in 0.5% usually reversible .
theththethe drugs that reduce the the coagulablity of the blood is called
"Anticoagulants".
HEPARIN:
It was discovered by Mclean in 1916. It was named 'heparin' as it was first extracted from liver .It is a
mucopolysaccharide found in the mast cells of the liver, lungs and industrial .
OTHER ACTION:
heparin activates lipoprotein lipase> hydrolysis triclycerides in the plasma> clearance of lipids in
plasma.
Mechanism of action:
molecular weight -10000 to 30000 heparin >binds and activates plasma antithrombin III (1000 folds
faster)> degrades thrombin and factors 10a 9a > prevents conversion of fibrinogen to fibrin >
Anticoagulant effect
Pharmacokinetics:
Route of administration : IV or SC
Dosage of action : peak in 5-10 mins returns to normal in 2-4 hours.
Metabolised by heparinase in liver.
Monitored by clotting time .
Dose and administration:
Bolus dose : 5000 IU
Maintenance dose : 1000-1500 IU
apTT : 1.5-2 times the control value
CT : 1.8 - 2.5 times then normal apTT
Prophylaxis dose:5000 IU SC every 8 to 12 hours.
Adverse effects:
bleeding
allergic reactions
hypersensitivity reactions
heparin induced thrombocytopenia
alopecia (hair loss) after 5 - 10 days in 0.5% usually reversible .
