1
USMLE
USMLE Step 1 Rapid Review Exam
Questions with Correct Verified
Solutions 100% Guaranteed Pass
1. Green-yellow rings around peripheral iris - ANS ✓Kayser-
Fleischer rings (copper accumulation from Wilson's disease)
2. Hamartomatous GI polyps, hyperpigmentation of mouth, feet
and hands - ANS ✓Peutz-Jeghers syndrome
3. Hepatosplenomegaly, osteoporosis, neurologic symptoms,
crinkled cytoplasm - ANS ✓Gaucher's disease (glucocerebrosidase
deficiency)
4. Hereditary nephritis, sensorineural hearing loss, cataracts - ANS
✓Alport's syndrome (type IV collagen)
5. Hypercoagulability leading to thrombophlebitis - ANS
✓Trousseau's sign (adenocarcinoma of pancreas or lung)
6. Hyperphagia, hypersexuality, hyperorality, hyperdocility - ANS
✓Kluver-Bucy syndrome (bilateral amygdala)
7. HTN, hypoK, metabolic alkalosis - ANS ✓Conn's (1* hyper
aldosterone)
USMLE Step 1 Rapid Review
, 2
USMLE
8. Hypoxemia, polycythaemia, hypercapnia - ANS ✓Blue bloater
(chronic bronchitis)
9. Indurated, ulcerated genital lesion - ANS ✓Nonpainful = syphilis.
Painful with exudate = chancroid
10. Infant with failure to thrive, hepatosplenomegaly,
neurodegeneration - ANS ✓Niemann-Pick disease (genetic
sphingomyelinase deficiency)
11. Infant with hypoglycaemia, failure to thrive, and
hepatomegaly - ANS ✓Cori's disease (debranching enzyme
deficiency, no glycogenolysis) or Von Gierke's
12. Infant with microcephaly, rocker-bottom feet, clenched
hands, and structural heart defect - ANS ✓Edward's syndrome
(Trisomy 18)
13. Jaundice, RUQ pain, fever - ANS ✓Charcot's triad (ascending
cholangitis)
14. Keratin pearls - ANS ✓Squamous cell carcinoma
15. Large rash with bull's eye appearance - ANS ✓Erythema
chronicum migrans from Ixodes tick bite (Lyme)
16. Lucid interval after TBI - ANS ✓Epidural hematoma (middle
meningeal artery)
USMLE Step 1 Rapid Review
, 3
USMLE
17. Male child, recurrent infections, no mature B cells - ANS
✓Bruton's disease (X-linked agammaglobulinemia)
18. Mucosal bleeding and prolonged bleeding time - ANS
✓Glanzmann's thrombasthenia (defect in platelet aggregation due to
lack of GpIIb/IIIa)
19. Multiple colon polyps, osteomas / soft tissue tumors,
impacted / supernumary teeth - ANS ✓Gardner's syndrome
20. Necrotizing vasculitis (lungs) and necrotizing GN - ANS
✓Wegner's (c-ANCA) and Goodpasture's (anti-GBM). Wegner's can
also have upper airway involvement
21. Neonate with arm paralysis following difficult birth.
Possible clavicle fx, probably large for gestational age - ANS
✓Erb-Duchenne palsy
22. No lactation postpartum, absent menstruation, cold
intolerance - ANS ✓Sheehan's syndrome
23. Nystagmus, intention tremor, scanning speech, also
bilateral internuclear ophthalmoplegia - ANS ✓MS (Charcot's)
24. Oscillating slow / fast breathing - ANS ✓Cheyne-Stokes
(central apnea from CHF or increased ICP)
USMLE Step 1 Rapid Review
USMLE
USMLE Step 1 Rapid Review Exam
Questions with Correct Verified
Solutions 100% Guaranteed Pass
1. Green-yellow rings around peripheral iris - ANS ✓Kayser-
Fleischer rings (copper accumulation from Wilson's disease)
2. Hamartomatous GI polyps, hyperpigmentation of mouth, feet
and hands - ANS ✓Peutz-Jeghers syndrome
3. Hepatosplenomegaly, osteoporosis, neurologic symptoms,
crinkled cytoplasm - ANS ✓Gaucher's disease (glucocerebrosidase
deficiency)
4. Hereditary nephritis, sensorineural hearing loss, cataracts - ANS
✓Alport's syndrome (type IV collagen)
5. Hypercoagulability leading to thrombophlebitis - ANS
✓Trousseau's sign (adenocarcinoma of pancreas or lung)
6. Hyperphagia, hypersexuality, hyperorality, hyperdocility - ANS
✓Kluver-Bucy syndrome (bilateral amygdala)
7. HTN, hypoK, metabolic alkalosis - ANS ✓Conn's (1* hyper
aldosterone)
USMLE Step 1 Rapid Review
, 2
USMLE
8. Hypoxemia, polycythaemia, hypercapnia - ANS ✓Blue bloater
(chronic bronchitis)
9. Indurated, ulcerated genital lesion - ANS ✓Nonpainful = syphilis.
Painful with exudate = chancroid
10. Infant with failure to thrive, hepatosplenomegaly,
neurodegeneration - ANS ✓Niemann-Pick disease (genetic
sphingomyelinase deficiency)
11. Infant with hypoglycaemia, failure to thrive, and
hepatomegaly - ANS ✓Cori's disease (debranching enzyme
deficiency, no glycogenolysis) or Von Gierke's
12. Infant with microcephaly, rocker-bottom feet, clenched
hands, and structural heart defect - ANS ✓Edward's syndrome
(Trisomy 18)
13. Jaundice, RUQ pain, fever - ANS ✓Charcot's triad (ascending
cholangitis)
14. Keratin pearls - ANS ✓Squamous cell carcinoma
15. Large rash with bull's eye appearance - ANS ✓Erythema
chronicum migrans from Ixodes tick bite (Lyme)
16. Lucid interval after TBI - ANS ✓Epidural hematoma (middle
meningeal artery)
USMLE Step 1 Rapid Review
, 3
USMLE
17. Male child, recurrent infections, no mature B cells - ANS
✓Bruton's disease (X-linked agammaglobulinemia)
18. Mucosal bleeding and prolonged bleeding time - ANS
✓Glanzmann's thrombasthenia (defect in platelet aggregation due to
lack of GpIIb/IIIa)
19. Multiple colon polyps, osteomas / soft tissue tumors,
impacted / supernumary teeth - ANS ✓Gardner's syndrome
20. Necrotizing vasculitis (lungs) and necrotizing GN - ANS
✓Wegner's (c-ANCA) and Goodpasture's (anti-GBM). Wegner's can
also have upper airway involvement
21. Neonate with arm paralysis following difficult birth.
Possible clavicle fx, probably large for gestational age - ANS
✓Erb-Duchenne palsy
22. No lactation postpartum, absent menstruation, cold
intolerance - ANS ✓Sheehan's syndrome
23. Nystagmus, intention tremor, scanning speech, also
bilateral internuclear ophthalmoplegia - ANS ✓MS (Charcot's)
24. Oscillating slow / fast breathing - ANS ✓Cheyne-Stokes
(central apnea from CHF or increased ICP)
USMLE Step 1 Rapid Review
