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Psychopharm PowerPoint Study Guide .

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68 terms 17 terms 144 terms




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FDA puts this warning as the strictest warning on the label. The

Black box warning medication is highly likely to cause the side effect it is warning

about.


Affinity of a drug is how strong the drug attaches to a receptor.


Agonist increases the effects of the drug


Partial Antagonist partially decreases the effect of the drug


Full Antagonist completely decreases the effect of the drug.


Neurotransmitter chemical messenger between neurons.


Cerebrum has two hemispheres. left to right


What does the right hemisphere The right hemisphere controls the left side of the body.

of the cerebrum control?


What does the left hemisphere The left hemisphere controls the right side of the body.

of the cerebrum control?


The hemispheres are divided frontal, parietal, occipital, temporal

into 4 lobes


Grey matter contains neuronal Hippocampus, the amygdala, andthe basal ganglia.

cell bodies. Pockets of grey

matter in the cerebrum include:


fear, anger, sadness, and AGGRESSION. It is the temporal lobe.

There is an amygdala on each side of the brain. Helps to store
The Amygdala processes what?
memories of bad events and presents that fear in the future.

Example: You were in a car accident. Now you are afraid to drive.


Hyperactive amygdala may be in schizophrenia and trauma

seen.


Hippocampus helps. make new memories


"Emotional brain" The hippocampus, amygdala, hypothalamus,
Limbic system
and thalamus. Antianxiety agents slow the limbic system.


shrinkage of the prefrontal cortex including the hippocampus
Chronic stress can cause.
and grey matter

, Shrinkage of the prefrontal to depression and addiction.

cortex may lead


Movement is regulated by the basal ganglia including movement of the diaphragm


Drugs that affect the basal may affect speech patterns (slurred speech, stuttering).

ganglia


• Basal ganglia - major role in motor responses and extrapyramidal side effects


Basal ganglia changes may EPS and tardive dyskinesia.

cause two types of movement

disturbances:


The brainstem is composed of Composed of the pons, medulla, and the midbrain


Composed of the pons, medulla, and the midbrain

• Basic vital life functions

• Brainstem regulates sleep and wake cycle, consciousness, and

wakefulness.
BRAIN FUNCTIONS -
• The Pons - regulates respirations and interprets senses such as
BRAINSTEM
smell, taste, hearing.

• Midbrain - eye movements, processing of visual and auditory

stimuli

*Medulla - digestion, sneezing, swallowing


• Motor control and cognitive processing

• Balance, coordination, posture, and gait
BRAIN FUNCTIONS -
• Impairments in attentional and emotional control in
CEREBELLUM
schizophrenia

• Lithium targets cerebellum function in bipolar disorder.


Filters sensory information before it reaches the cerebral cortex.
BRAIN FUNCTIONS -
• In Schizophrenia there is altered connections between the
THALAMUS
thalamus and the prefrontal cortex.


Maintains homeostasis

• Regulates temperature, blood pressure, libido, thirst, and

circadian rhythms.

• Releases neurohormones that direct secretions of hormones
BRAIN FUNCTIONS -
from the anterior pituitary gland.
HYPOTHALAMUS
• Hypothalamus -> corticotrophin-releasing hormone (CRH) ->

pituitary-> corticotrophin -> adrenal cortex-> cortisol

.• CRH release is disrupted in depression, Alzheimer's disease,

substance use disorder, and insomnia.


Cognition, motivation, and movement

• Stimulates the heart and blood flow to organs

Dopamine

• High levels: Schizophrenia, Mania.

Low levels: Parkinson’s disease, depression


Helps with skeletal muscle movement, arousal, memory,

sleep/wake cycle.

Acetylcholine High levels: depression

Low levels: Alzheimer’s disease, Huntington’s chorea, Parkinson’s

disease

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