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• NURS 6230 Advanced Pathophysiology Midterm Questions 2025 Guide

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• NURS 6230 Advanced Pathophysiology Midterm Questions 2025 Guide

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1. In which of the following conditions would you expect an
increase in erythrocyte sedimentation rate (ESR)?
A. Acute inflammation
B. Dehydration
C. Iron deficiency anemia
D. Chronic hypertension
Answer: A) Acute inflammation
Rationale: ESR is an indicator of inflammation. It increases during
acute inflammatory processes, such as infections, autoimmune
diseases, and other inflammatory conditions.

2. Which of the following is the most common cause of stroke?
A. Aneurysm rupture
B. Ischemia due to a clot
C. Brain tumor
D. Hypertension
Answer: B) Ischemia due to a clot
Rationale: Ischemic strokes are the most common type of stroke
and occur when a clot blocks blood flow to the brain.

3. What is the main cause of liver cirrhosis?
A. Alcohol abuse
B. High-fat diet
C. Viral infections (e.g., hepatitis B or C)
D. Obesity
Answer: A) Alcohol abuse
Rationale: Chronic alcohol use is the leading cause of cirrhosis,
leading to liver fibrosis and eventual liver failure.

4. What is the most common cause of secondary osteoporosis?
A. Calcium deficiency

,B. Hyperparathyroidism
C. Long-term use of corticosteroids
D. Vitamin D deficiency
Answer: C) Long-term use of corticosteroids
Rationale: Long-term corticosteroid use is a major cause of
secondary osteoporosis due to its effect on bone metabolism,
leading to decreased bone density and increased fracture risk.

5. Which of the following factors is most likely to increase the
risk of deep vein thrombosis (DVT)?
A. Frequent physical activity
B. Use of oral contraceptives
C. Low body weight
D. Dehydration
Answer: B) Use of oral contraceptives
Rationale: Oral contraceptives can increase clotting factor
production, which elevates the risk of DVT.

6. A patient with acute blood loss from a traumatic injury may
experience which of the following?
A. Decreased heart rate
B. Decreased respiratory rate
C. Increased blood pressure
D. Increased heart rate
Answer: D) Increased heart rate
Rationale: Acute blood loss leads to a decrease in circulating
blood volume, which triggers compensatory tachycardia
(increased heart rate) to maintain cardiac output.

7. Which of the following lab results is most likely in a patient
with dehydration?
A. Low hematocrit
B. Low sodium levels

, C. Elevated blood urea nitrogen (BUN)
D. Low creatinine
Answer: C) Elevated blood urea nitrogen (BUN)
Rationale: Dehydration leads to decreased renal perfusion and an
increase in BUN due to reduced fluid volume.

8. A nurse is caring for a patient with hyperkalemia. What is the
most concerning sign of this condition?
A. Muscle weakness
B. Shortness of breath
C. Diarrhea
D. Nausea
Answer: A) Muscle weakness
Rationale: Hyperkalemia can cause muscle weakness and
potentially life-threatening arrhythmias due to its effect on the
electrical conductivity of the heart.

9. In which condition would you expect to find a low white blood
cell (WBC) count?
A. Viral infection
B. Leukemia
C. Bacterial infection
D. Bone marrow suppression
Answer: D) Bone marrow suppression
Rationale: Bone marrow suppression, often caused by
chemotherapy or certain diseases, can result in low WBC counts
(leukopenia).

10. Which of the following is the most likely cause of anaphylactic
shock?
A. Blood loss
B. Allergic reaction
C. Bacterial infection

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