Wound Healing in Pathology - BSc Nursing 2nd Year
Definition:
Wound healing is the physiological process by which the body repairs tissue damage. It involves a
complex series of events including cell migration, proliferation, and tissue remodeling.
Phases of Wound Healing:
1. Hemostasis (Immediate):
- Begins at the time of injury.
- Blood vessels constrict, and platelets form a clot.
- Fibrin mesh forms a temporary matrix.
2. Inflammatory Phase (0-3 days):
- Vasodilation occurs, allowing immune cells to enter the wound.
- Neutrophils and macrophages remove debris and pathogens.
- Signs: redness, swelling, heat, pain.
3. Proliferative Phase (3-21 days):
- Fibroblasts produce collagen and extracellular matrix.
- Angiogenesis (new blood vessel formation) occurs.
- Granulation tissue forms and epithelial cells migrate across the wound.
4. Maturation/Remodeling Phase (up to 1 year):
- Collagen is reorganized and cross-linked for tensile strength.
- Scar tissue forms, and unnecessary blood vessels regress.
Types of Wound Healing:
Definition:
Wound healing is the physiological process by which the body repairs tissue damage. It involves a
complex series of events including cell migration, proliferation, and tissue remodeling.
Phases of Wound Healing:
1. Hemostasis (Immediate):
- Begins at the time of injury.
- Blood vessels constrict, and platelets form a clot.
- Fibrin mesh forms a temporary matrix.
2. Inflammatory Phase (0-3 days):
- Vasodilation occurs, allowing immune cells to enter the wound.
- Neutrophils and macrophages remove debris and pathogens.
- Signs: redness, swelling, heat, pain.
3. Proliferative Phase (3-21 days):
- Fibroblasts produce collagen and extracellular matrix.
- Angiogenesis (new blood vessel formation) occurs.
- Granulation tissue forms and epithelial cells migrate across the wound.
4. Maturation/Remodeling Phase (up to 1 year):
- Collagen is reorganized and cross-linked for tensile strength.
- Scar tissue forms, and unnecessary blood vessels regress.
Types of Wound Healing:
