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• 2025 NURS 6230 Midterm Advanced Pathophysiology Exam Guide

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• 2025 NURS 6230 Midterm Advanced Pathophysiology Exam Guide

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1. What is a classic symptom of Parkinson’s disease?
A. Muscle rigidity
B. Hypotension
C. Polyuria
D. Weight gain
Answer: A) Muscle rigidity
Rationale: Parkinson’s disease is characterized by symptoms such
as muscle rigidity, tremors, and bradykinesia due to a loss of
dopaminergic neurons in the brain.

2. What is the most common cause of secondary osteoporosis?
A. Calcium deficiency
B. Hyperparathyroidism
C. Long-term use of corticosteroids
D. Vitamin D deficiency
Answer: C) Long-term use of corticosteroids
Rationale: Long-term corticosteroid use is a major cause of
secondary osteoporosis due to its effect on bone metabolism,
leading to decreased bone density and increased fracture risk.

3. A patient with acute bacterial meningitis is likely to experience
which of the following?
A. Increased thirst and urination
B. Severe headache and neck stiffness
C. Joint pain and swelling
D. Abdominal pain and bloating
Answer: B) Severe headache and neck stiffness
Rationale: Acute bacterial meningitis causes inflammation of the
meninges, leading to symptoms like severe headache, neck
stiffness, photophobia, and fever.

,4. Which of the following is a common cause of hypoxemia?
A. Anemia
B. Asthma
C. Hypertension
D. Diabetes
Answer: B) Asthma
Rationale: Asthma causes bronchoconstriction and inflammation
in the airways, leading to decreased oxygen exchange and
resulting in hypoxemia.

5. A patient with a diagnosis of systemic lupus erythematosus
(SLE) is at increased risk for which of the following?
A. Infection
B. Weight loss
C. Hyperthyroidism
D. Stroke
Answer: A) Infection
Rationale: SLE is an autoimmune disorder that affects the immune
system, leaving the patient at higher risk for infections due to
immunosuppressive therapy and the disease itself.

6. What is the primary cause of osteoarthritis?
A. Autoimmune reaction
B. Wear and tear on the joints
C. Bacterial infection
D. Vitamin D deficiency
Answer: B) Wear and tear on the joints
Rationale: Osteoarthritis is primarily caused by the degeneration
of cartilage due to repetitive use or aging, leading to joint pain
and stiffness.

7. In which condition would you expect to find a low white blood
cell (WBC) count?

, A. Viral infection
B. Leukemia
C. Bacterial infection
D. Bone marrow suppression
Answer: D) Bone marrow suppression
Rationale: Bone marrow suppression, often caused by
chemotherapy or certain diseases, can result in low WBC counts
(leukopenia).

8. A patient with a history of gout presents with severe joint pain
in the big toe. What is the most likely cause of this pain?
A. Hyperuricemia
B. Osteoarthritis
C. Rheumatoid arthritis
D. Bone fracture
Answer: A) Hyperuricemia
Rationale: Gout is caused by the accumulation of uric acid crystals
in the joints, often beginning with the big toe. Elevated uric acid
levels (hyperuricemia) lead to these crystals forming and causing
intense pain.

9. A patient with a history of chronic pancreatitis is at increased
risk for which of the following complications?
A. Diabetes mellitus
B. Hypoglycemia
C. Hyperkalemia
D. Asthma
Answer: A) Diabetes mellitus
Rationale: Chronic pancreatitis can damage the pancreas' ability
to secrete insulin, leading to insulin resistance and an increased
risk of diabetes mellitus.

10. A patient with chronic kidney disease (CKD) is most at risk for

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