PHARMACOLOGY ADVANCED QUESTIONS BANK NEWEST 2024-2025 ACTUAL EXAM COMPLETE 200
QUESTIONS AND CORRECT DETAILED ANSWERS
Pharmacokinetics Basic Definition - (answer) What the body does to the drug
Pharmacokinetics 4 Main Elements - (answer) 1. Absorbs
2. Distributes
3. Metabolizes (Biotransformation)
4. Eliminates
Types of transport - (answer) Passive - Moves along the concentration gradient
- Simple Diffusion -(must be fat soluble, will need a carrier protein once it reaches water)
- Channel Mediated
- Carrier Mediated
Active - Moves AGAINST the concentration gradient
Fat Soluble - Regarding transport - (answer) Can move across membrane anywhere, so it is absorbed
QUICKER
Water Soluble - Regarding transport - (answer) Must find a channel to travel through - SLOWER to
absorb
2 things that solubility is affected by: - (answer) pH (acid or base) and charge
Acidic drug in a solution - (answer) Disassociates - releases a H+ ion
Basic drug in a solution - (answer) Picks up - binds to - a hydrogen ion
A CHARGED (ionized) molecule is _______________ soluble - (answer) WATER
An UNCHARGED (non-ionized) molecule is _______________ soluble - (answer) FAT
, PHARMACOLOGY ADVANCED QUESTIONS BANK NEWEST 2024-2025 ACTUAL EXAM COMPLETE 200
QUESTIONS AND CORRECT DETAILED ANSWERS
ACID FORMULA - (answer) HA ⇄ H+ + A- Protonated acid has NO charge
BASE FORMULA - (answer) BH+ ⇄ B+ H+ Protonated base has a CHARGE
An acidic environment tends to move the reaction to the ________ - (answer) LEFT
A basic environment tends to move the reaction to the ___________ - (answer) RIGHT
pka of a drug - (answer) What the DRUG sees as neutral. constant chemical prop. of a drug pH where
there are equal concentrations of charged and uncharged molecules.
The farther from pka the environment pH is the more buffering the drug will do - the stronger it will
favor the opposite.
ALAN - (answer) A - acidic environment moves the reaction
L - Left making the
A - Acid
N - Non-ionized (Fat Soluble)
BRAIN - (answer) B - basic environment moves the reaction
R - Right and makes
A - Acid
I - Ionized and the base
N - Non-ionized
Drug distribution is affected by:
(4 items) - (answer) - Blood Flow : ↑ blood flow = ↑ drug delivered
- Solubility : must be in a form that is capable of crossing the cell membrane. Fat soluble - more efficient
- Plasma Protein Binding : ↑ affinity for binding = ↓ drug distribution (stays bound to protein and stuck
in plasma)
QUESTIONS AND CORRECT DETAILED ANSWERS
Pharmacokinetics Basic Definition - (answer) What the body does to the drug
Pharmacokinetics 4 Main Elements - (answer) 1. Absorbs
2. Distributes
3. Metabolizes (Biotransformation)
4. Eliminates
Types of transport - (answer) Passive - Moves along the concentration gradient
- Simple Diffusion -(must be fat soluble, will need a carrier protein once it reaches water)
- Channel Mediated
- Carrier Mediated
Active - Moves AGAINST the concentration gradient
Fat Soluble - Regarding transport - (answer) Can move across membrane anywhere, so it is absorbed
QUICKER
Water Soluble - Regarding transport - (answer) Must find a channel to travel through - SLOWER to
absorb
2 things that solubility is affected by: - (answer) pH (acid or base) and charge
Acidic drug in a solution - (answer) Disassociates - releases a H+ ion
Basic drug in a solution - (answer) Picks up - binds to - a hydrogen ion
A CHARGED (ionized) molecule is _______________ soluble - (answer) WATER
An UNCHARGED (non-ionized) molecule is _______________ soluble - (answer) FAT
, PHARMACOLOGY ADVANCED QUESTIONS BANK NEWEST 2024-2025 ACTUAL EXAM COMPLETE 200
QUESTIONS AND CORRECT DETAILED ANSWERS
ACID FORMULA - (answer) HA ⇄ H+ + A- Protonated acid has NO charge
BASE FORMULA - (answer) BH+ ⇄ B+ H+ Protonated base has a CHARGE
An acidic environment tends to move the reaction to the ________ - (answer) LEFT
A basic environment tends to move the reaction to the ___________ - (answer) RIGHT
pka of a drug - (answer) What the DRUG sees as neutral. constant chemical prop. of a drug pH where
there are equal concentrations of charged and uncharged molecules.
The farther from pka the environment pH is the more buffering the drug will do - the stronger it will
favor the opposite.
ALAN - (answer) A - acidic environment moves the reaction
L - Left making the
A - Acid
N - Non-ionized (Fat Soluble)
BRAIN - (answer) B - basic environment moves the reaction
R - Right and makes
A - Acid
I - Ionized and the base
N - Non-ionized
Drug distribution is affected by:
(4 items) - (answer) - Blood Flow : ↑ blood flow = ↑ drug delivered
- Solubility : must be in a form that is capable of crossing the cell membrane. Fat soluble - more efficient
- Plasma Protein Binding : ↑ affinity for binding = ↓ drug distribution (stays bound to protein and stuck
in plasma)
