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A 45-year-old man has a mild heart attack and a history of vascular disease. He is
placed on a Mediterranean diet and statin drug therapy. Which of the following will be
the most likely result of this drug therapy?
a. low blood LDLs
b. high blood glucose
c. low blood glucose
d. high blood cholesterol - CORRECT ANSWER: low blood LDLs
A 45-year-old man is found to have an elevated serum cholesterol of 300mg/dL after a
12 hr fast. Which of the following lipoproteins would be the largest contributors to a
measurement of plasma cholesterol in a normal person following a 12 hr. fast?
a. Chylomicron remnants and VLDL
b. Chylomicrons and VLDLs
c. HDLs and LDLs
d. VLDLs and LDLs - CORRECT ANSWER: HDLs and LDLs
A defect in the thioesterase subunit of fatty acid synthase would impair which of the
following activities of the enzyme complex?
a. liberation of Co2 from 3-ketoacyl synthase
b. binding of malonyl-CoA to an SH group
c. liberation of newly assembled palmitate from the enzyme
d. priming of the enzyme with acetyl-CoA - CORRECT ANSWER: liberation of newly
assembled palmitate from the enzyme
, A well, 2-year-old girl presents to the clinic with symptoms of a viral illness. Her parents
report she has had bouts of vomiting and diarrhea over the last 24 hours. This morning
they could barely wake her from her crib and she was very weak. Laboratory tests show
low blood glucose (hypoglycemia) and elevated liver enzymes. There are no ketones
present in her urine. The child is hospitalized and glucose is administered by I.V.
Additional laboratory tests showed elevated medium-chain fatty acyl carnitines in blood
and 6-8 carbon dicarboxylic acids in the urine. Which of the following abnormalities is
the most likely diagnosis for this child? - CORRECT ANSWER: Defect of medium-chain
coenzyme A dehydrogenase
An individual is on a hunger strike and has not eaten in 13 days. Which of the following
best describes their metabolic state?
a. glycolysis will be highly active
b. the brain will be preferentially oxidizing ketones
c. glycogenolysis will be the primary source of blood glucose
d. skeletal muscle will be primarily oxidizing glucose - CORRECT ANSWER: the brain
will be preferentially oxidizing ketones (under conditions of starvation, the brain will
begin to oxidize ketones as a primary fuel source reducing it's reliance on glucose)
ATP can be generated by many metabolic pathways in the body. Which of the following
processes generates the most ATP?
a. glycogenolysis
b. fatty acid β-oxidation
c. pentose phosphate pathway
d. citric acid cycle - CORRECT ANSWER: Fatty acid β-oxidation
Bile salts are synthesized from cholesterol and are used for the emulsification of dietary
lipids. What is the primary fate of bile salts during digestion?
a. they are digested by pancreatic lipase
b. they are reabsorbed in the ileum
c. they are packaged into chylomicrons