PHAR 542 Bone & Joint Infections
1. Osteomyelitis Microbiology: Contiguous: Usually S.aureus,
CoNS, or GNR
2. Osteomyelitis Treatment: - Surgical debridement plus
antimicrobial therapy
- Usually start with IV therapy
- Most patients will receive broad-spectrum antibiotics with Gram+
and Gram- activity (for example, ceftriaxone and vancomycin).
- De-escalate once cultures available.
3. Osteomyelitis Treatment Duration: 6 weeks (possibly longer)
4. Septic Arthritis Microbiology: Usually monomicrobial.
Staphylococci and strep- tococci are most common pathogens.
5. Septic Arthritis Treatment: - Usually start with IV therapy
- Specific choice of empiric therapy depends on patient history,
risk factors, and Gram stain results from joint aspiration. For
example, if GPC present on Gram stain, give vancomycin or
cefazolin. If Gram- present, give 3rd/4th gen cephalosporin
6. Septic Arthritis treatment Duration: ~4 weeks
7. Prosthetic Joint Infections (PJI): Total hip arthroplasty (THA)
and total knee arthroplasty (TKA)
1. Osteomyelitis Microbiology: Contiguous: Usually S.aureus,
CoNS, or GNR
2. Osteomyelitis Treatment: - Surgical debridement plus
antimicrobial therapy
- Usually start with IV therapy
- Most patients will receive broad-spectrum antibiotics with Gram+
and Gram- activity (for example, ceftriaxone and vancomycin).
- De-escalate once cultures available.
3. Osteomyelitis Treatment Duration: 6 weeks (possibly longer)
4. Septic Arthritis Microbiology: Usually monomicrobial.
Staphylococci and strep- tococci are most common pathogens.
5. Septic Arthritis Treatment: - Usually start with IV therapy
- Specific choice of empiric therapy depends on patient history,
risk factors, and Gram stain results from joint aspiration. For
example, if GPC present on Gram stain, give vancomycin or
cefazolin. If Gram- present, give 3rd/4th gen cephalosporin
6. Septic Arthritis treatment Duration: ~4 weeks
7. Prosthetic Joint Infections (PJI): Total hip arthroplasty (THA)
and total knee arthroplasty (TKA)
