APPROACH TO POISONING
AND TOXIDROMES
(Cholinergics, Anti-cholinergics, Symphatomimetics)/OP Poisoning, PCM an
Salicyclate Toxicity
Presenters:
1. Mohd Syafiq Hakim
2. Atiqah Safawati Binti Idris
EP: Dr. Zaim
,OP poisoning, PCM,
Salicylates Toxicity
Muhammad Syafiq Hakim
,Definition of OP poisoning Diagnosis
• OP poisoning refers to toxic • Clinical diagnosis (history +
effects resulting from exposure cholinergic toxidrome)
to organophosphate • Confirmatory:
compounds, which inhibit
acetylcholinesterase (AChE), ❖↓ Plasma
leading to accumulation of pseudocholinesterase
acetylcholine at synapses. ❖↓ RBC acetylcholinesterase
(more specific but less availab
• Others: ABG (for hypoxia), CXR
(aspiration), ECG (bradycardia
, Mechanism of Action
• Irreversible inhibition of AChE → ↑ acetylcholine → overstimulatio
of:
❖Muscarinic receptors (smooth muscle, glands)
❖Nicotinic receptors (neuromuscular junction)
❖CNS receptors
AND TOXIDROMES
(Cholinergics, Anti-cholinergics, Symphatomimetics)/OP Poisoning, PCM an
Salicyclate Toxicity
Presenters:
1. Mohd Syafiq Hakim
2. Atiqah Safawati Binti Idris
EP: Dr. Zaim
,OP poisoning, PCM,
Salicylates Toxicity
Muhammad Syafiq Hakim
,Definition of OP poisoning Diagnosis
• OP poisoning refers to toxic • Clinical diagnosis (history +
effects resulting from exposure cholinergic toxidrome)
to organophosphate • Confirmatory:
compounds, which inhibit
acetylcholinesterase (AChE), ❖↓ Plasma
leading to accumulation of pseudocholinesterase
acetylcholine at synapses. ❖↓ RBC acetylcholinesterase
(more specific but less availab
• Others: ABG (for hypoxia), CXR
(aspiration), ECG (bradycardia
, Mechanism of Action
• Irreversible inhibition of AChE → ↑ acetylcholine → overstimulatio
of:
❖Muscarinic receptors (smooth muscle, glands)
❖Nicotinic receptors (neuromuscular junction)
❖CNS receptors
