12/29/23,vj8:42vjA TestvjBankvj-
M vjCellularvjandvjMolecularvjImmunology,vj10thvjEditionvj(Abbas,vj2022)
TestvjBankvj -vj Cellularvj andvj Molecularvj Immunology,vj 10thvjEditionvj (Abbas,vj2022)
Chaptervj01:vjPropertiesvjandvjOverviewvjofvjImmunevjResponses
Abbas,vj Lichtman,vj andvj Pillai:vj Cellularvj andvj Molecularv j Immunology,vj 10thv j Edition
MULTIPLEv j CHOICE
1. Thevjprincipalvjfunctionvjofvjthevjimmunevjsystemvjis:
a. Defensevjagainstvjcancer
b. Repairvjofvjinjuredvjtissues
c. Defensevjagainstvjmicrobialvjinfections
d. Preventionvjofvjinflammatoryvjdiseases
e. Protectionvjagainstvjenvironmentalvjtoxins
ANS:v j C
Thevjimmunevjsystemvjhasvjevolvedvjinvjthevjsettingvjofvjselectivevjpressuresvjimposedvj
byvjmicrobialv j infections.vjAlthoughvjimmunevjresponsesvjtovjcancervjmayvjoccur,vjthe
vjconceptvjthatv j “immunosurveillance”vjagainstvjcancervjisvjavjprincipalvjfunctionvjofvjt
hevjimmunevjsystemvjisv j controversial.vjRepairvjofvjinjuredvjtissuesvjmayvjbevjavjseco
ndaryvjconsequencevjofvjthevjimmunev j responsesvjandvjinflammation.vjAlthoughvjthevj
immunevjsystemvjhasvjregulatoryvjfeaturesvjthatvjarev j neededvjtovjpreventvjexcessivevji
nflammation,vjpreventionvjofvjinflammatoryvjdiseasesvjisvjnotvjav j primaryvjfunction.vjT
hevjimmunevjsystemvjcanvjprotectvjagainstvjmicrobialvjtoxins,vjbutvjitvjgenerallyv j doesvj
notvjoffervjprotectionvjagainstvjtoxinsvjofvjnonbiologicvjorigin.
2. Whichvjofvjthevjfollowingvjinfectiousvjdiseasesvjwasvjpreventedvjbyvjthevjfirst
vjsuccessfulv j vaccination?
a. Polio
b. Tuberculosis
c. Smallpox
d. Tetanus
e. Rubella
ANS:v j C
Invj1798,vjEdwardvjJennervjreportedvjthevjfirstvjintentionalvjsuccessfulvjvaccination,vjwh
ichvjwasv j againstvjsmallpoxvjinvjavjboy,vjusingvjmaterialvjfromvjthevjcowpoxvjpustulesv
jofvjavjmilkmaid.vjInvj1980,v j smallpoxvjwasvjreportedvjtovjbevjeradicatedvjworldwidevj
byvjavjvaccinationvjprogram.vjEffectivev j vaccinesvjagainstvjtetanusvjtoxin,vjrubellavjvir
us,vjandvjpoliovirusvjwerevjdevelopedvjinvjthevj20thv j centuryvjandvjarevjwidelyvjused.v
jTherevjisvjnovjeffectivevjvaccinevjagainstvjMycobacteriumv j tuberculosis.
3. Whichvjofvjthevjfollowingvjisvjavjuniquevjpropertyvjofvjthevjadaptivevjimmunevjsystem?
a. Highlyvjdiversevjrepertoirevjofvjspecificitiesvjforvjantigens
b. Self-nonselfvjdiscrimination
c. Recognitionvjofvjmicrobialvjstructuresvjbyvjbothvjcell-associatedvjandvjsolublevjreceptors
d. Protectionvjagainstvjviralvjinfections
e. Responsesvjthatvjhavevjthevjsamevjkineticsvjandvjmagnitudevjonvjrepeatedvjexpo
surevjtovjthev j samevjmicrobe
ANS:v j A
DownloadvjAllvjChaptersvjHere:
https://www.stuvia.com/doc/3022302/
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, 12/29/23,vj8:42vjA TestvjBankvj-
M vjCellularvjandvjMolecularvjImmunology,vj10thvjEditionvj(Abbas,vj2022)
TestvjBankvj -vj Cellularvj andvj Molecularvj Immunology,vj 10thvjEditionvj (Abbas,vj2022)
HighlyvjdiversevjrepertoiresvjofvjspecificitiesvjforvjantigensvjarevjfoundvjonlyvjinvjTvjan
dvjBv j lymphocytes,vjwhichvjarevjthevjcentralvjcellularvjcomponentsvjofvjthevjadaptivevj
immunevjsystem.v j Bothvjthevjinnatevjandvjthevjadaptivevjimmunevjsystemsvjusevjcell-
associatedvjandvjsolublevjreceptorsv j tovjrecognizevjmicrobes,vjdisplayvjsomevjdegreevjo
fvjself-
nonselfvjdiscrimination,vjandvjprotectv j againstvjviruses.vjOnvjrepeatedvjexposurevjtovjth
evjsamevjmicrobe,vjthevjadaptivevjimmunevjresponsev j becomesvjmorevjrapidvjandvjofvj
greatervjmagnitude;vjthisvjisvjthevjmanifestationvjofvjmemory.
4. AntibodiesvjandvjTvjlymphocytesvjarevjthevjrespectivevjmediatorsvjofvjwhichvjt
wovjtypesvjofv j immunity?
a. Innatevjandvjadaptive
b. Passivevjandvjactive
c. Specificvjandvjnonspecific
d. Humoralvjandvj cell-mediated
e. Adultvjandvjneonatal
ANS:v j D
BothvjBvjandvjTvjlymphocytesvjarevjprincipalvjcomponentsvjofvjadaptivevjimmunity.vjBvjl
ymphocytesv j producevjantibodies,vjwhichvjarevjthevjrecognitionvjandvjeffectorvjmolecules
vjofvjhumoralvjimmunev j responsesvjtovjextracellularvjpathogens.vjTvjcellsvjrecognizevjan
dvjpromotevjeradicationvjofv j intracellularvjpathogensvjinvjcell-
mediatedvjimmunity.vjPassivevjandvjactivevjimmunityvjbothvjcanvjbev j mediatedvjbyvjeithe
rvjBvjorvjTvjlymphocytes.vjSpecificvjimmunityvjisvjanothervjtermvjforvjadaptivev j immunit
y.vjBothvjBvjandvjTvjlymphocytesvjparticipatevjinvjadultvjadaptivevjimmunityvjbutvjarevjst
illv j developingvjinvjthevjneonatalvjperiod.
5. ThevjtwovjmajorvjfunctionalvjclassesvjofvjeffectorvjTvjlymphocytesvjare:
a. HelpervjTvjlymphocytesvjandvjcytotoxicvjTvjlymphocytes
b. NaturalvjkillervjcellsvjandvjcytotoxicvjTvjlymphocytes
c. MemoryvjTvjcellsvjandvjeffectorvjTvjcells
d. Helpervjcellsvjandvjantigen-presentingvjcells
e. CytotoxicvjTvjlymphocytesvjandvjtargetvjcells
ANS:v j A
Tvjcellsvjcanvjbevjclassifiedvjintovjeffectorvjsubsetsvjthatvjperformvjdifferentvjeffectorvjfu
nctions.vjMostv j effectorvjTvjcellsvjarevjeithervjhelpervjTvjlymphocytes,vjwhichvjenhanc
evjthevjresponsesvjofvjotherv j immunevjcells,vjincludingvjphagocytesvjandvjBvjcells,vjto
vjinfections,vjorvjcytotoxicvjTvjlymphocytes,v j whichvjdirectlyvjkillvjinfectedvjcells.vjNa
turalvjkillervjcellsvjarevjnotvjTvjlymphocytes.
Antigen-presentingvjcellsvjusuallyvjarevjnotvjTvjcells.vjMemoryvjTvjcellsvjarevjnotvjeffectorvjTvjcells.
6. Whichvjofvjthevjfollowingvjcellvjtypesvjisvjrequiredvjforvjallvjadaptivevjhumoralvjimmunevjresponses?
a. Naturalvjkillervjcells
b. Dendriticvjcells
c. CytolyticvjTvjlymphocytes
d. Bvjlymphocytes
e. HelpervjTvjlymphocytes
ANS:v j D
Humoralvjimmunevjresponsesvjarevjantibody-
mediatedvjimmunevjresponses,vjandvjallvjantibodiesv j arevjmadevjbyvjBvjlymphocytesvja
ndvjnovjothervjcellvjtype.
DownloadvjAllvjChaptersvjHere:
https://www.stuvia.com/doc/3022302/
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M vjCellularvjandvjMolecularvjImmunology,vj10thvjEditionvj(Abbas,vj2022)
TestvjBankvj -vj Cellularvj andvj Molecularvj Immunology,vj 10thvjEditionvj (Abbas,vj2022)
Chaptervj01:vjPropertiesvjandvjOverviewvjofvjImmunevjResponses
Abbas,vj Lichtman,vj andvj Pillai:vj Cellularvj andvj Molecularv j Immunology,vj 10thv j Edition
MULTIPLEv j CHOICE
1. Thevjprincipalvjfunctionvjofvjthevjimmunevjsystemvjis:
a. Defensevjagainstvjcancer
b. Repairvjofvjinjuredvjtissues
c. Defensevjagainstvjmicrobialvjinfections
d. Preventionvjofvjinflammatoryvjdiseases
e. Protectionvjagainstvjenvironmentalvjtoxins
ANS:v j C
Thevjimmunevjsystemvjhasvjevolvedvjinvjthevjsettingvjofvjselectivevjpressuresvjimposedvj
byvjmicrobialv j infections.vjAlthoughvjimmunevjresponsesvjtovjcancervjmayvjoccur,vjthe
vjconceptvjthatv j “immunosurveillance”vjagainstvjcancervjisvjavjprincipalvjfunctionvjofvjt
hevjimmunevjsystemvjisv j controversial.vjRepairvjofvjinjuredvjtissuesvjmayvjbevjavjseco
ndaryvjconsequencevjofvjthevjimmunev j responsesvjandvjinflammation.vjAlthoughvjthevj
immunevjsystemvjhasvjregulatoryvjfeaturesvjthatvjarev j neededvjtovjpreventvjexcessivevji
nflammation,vjpreventionvjofvjinflammatoryvjdiseasesvjisvjnotvjav j primaryvjfunction.vjT
hevjimmunevjsystemvjcanvjprotectvjagainstvjmicrobialvjtoxins,vjbutvjitvjgenerallyv j doesvj
notvjoffervjprotectionvjagainstvjtoxinsvjofvjnonbiologicvjorigin.
2. Whichvjofvjthevjfollowingvjinfectiousvjdiseasesvjwasvjpreventedvjbyvjthevjfirst
vjsuccessfulv j vaccination?
a. Polio
b. Tuberculosis
c. Smallpox
d. Tetanus
e. Rubella
ANS:v j C
Invj1798,vjEdwardvjJennervjreportedvjthevjfirstvjintentionalvjsuccessfulvjvaccination,vjwh
ichvjwasv j againstvjsmallpoxvjinvjavjboy,vjusingvjmaterialvjfromvjthevjcowpoxvjpustulesv
jofvjavjmilkmaid.vjInvj1980,v j smallpoxvjwasvjreportedvjtovjbevjeradicatedvjworldwidevj
byvjavjvaccinationvjprogram.vjEffectivev j vaccinesvjagainstvjtetanusvjtoxin,vjrubellavjvir
us,vjandvjpoliovirusvjwerevjdevelopedvjinvjthevj20thv j centuryvjandvjarevjwidelyvjused.v
jTherevjisvjnovjeffectivevjvaccinevjagainstvjMycobacteriumv j tuberculosis.
3. Whichvjofvjthevjfollowingvjisvjavjuniquevjpropertyvjofvjthevjadaptivevjimmunevjsystem?
a. Highlyvjdiversevjrepertoirevjofvjspecificitiesvjforvjantigens
b. Self-nonselfvjdiscrimination
c. Recognitionvjofvjmicrobialvjstructuresvjbyvjbothvjcell-associatedvjandvjsolublevjreceptors
d. Protectionvjagainstvjviralvjinfections
e. Responsesvjthatvjhavevjthevjsamevjkineticsvjandvjmagnitudevjonvjrepeatedvjexpo
surevjtovjthev j samevjmicrobe
ANS:v j A
DownloadvjAllvjChaptersvjHere:
https://www.stuvia.com/doc/3022302/
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, 12/29/23,vj8:42vjA TestvjBankvj-
M vjCellularvjandvjMolecularvjImmunology,vj10thvjEditionvj(Abbas,vj2022)
TestvjBankvj -vj Cellularvj andvj Molecularvj Immunology,vj 10thvjEditionvj (Abbas,vj2022)
HighlyvjdiversevjrepertoiresvjofvjspecificitiesvjforvjantigensvjarevjfoundvjonlyvjinvjTvjan
dvjBv j lymphocytes,vjwhichvjarevjthevjcentralvjcellularvjcomponentsvjofvjthevjadaptivevj
immunevjsystem.v j Bothvjthevjinnatevjandvjthevjadaptivevjimmunevjsystemsvjusevjcell-
associatedvjandvjsolublevjreceptorsv j tovjrecognizevjmicrobes,vjdisplayvjsomevjdegreevjo
fvjself-
nonselfvjdiscrimination,vjandvjprotectv j againstvjviruses.vjOnvjrepeatedvjexposurevjtovjth
evjsamevjmicrobe,vjthevjadaptivevjimmunevjresponsev j becomesvjmorevjrapidvjandvjofvj
greatervjmagnitude;vjthisvjisvjthevjmanifestationvjofvjmemory.
4. AntibodiesvjandvjTvjlymphocytesvjarevjthevjrespectivevjmediatorsvjofvjwhichvjt
wovjtypesvjofv j immunity?
a. Innatevjandvjadaptive
b. Passivevjandvjactive
c. Specificvjandvjnonspecific
d. Humoralvjandvj cell-mediated
e. Adultvjandvjneonatal
ANS:v j D
BothvjBvjandvjTvjlymphocytesvjarevjprincipalvjcomponentsvjofvjadaptivevjimmunity.vjBvjl
ymphocytesv j producevjantibodies,vjwhichvjarevjthevjrecognitionvjandvjeffectorvjmolecules
vjofvjhumoralvjimmunev j responsesvjtovjextracellularvjpathogens.vjTvjcellsvjrecognizevjan
dvjpromotevjeradicationvjofv j intracellularvjpathogensvjinvjcell-
mediatedvjimmunity.vjPassivevjandvjactivevjimmunityvjbothvjcanvjbev j mediatedvjbyvjeithe
rvjBvjorvjTvjlymphocytes.vjSpecificvjimmunityvjisvjanothervjtermvjforvjadaptivev j immunit
y.vjBothvjBvjandvjTvjlymphocytesvjparticipatevjinvjadultvjadaptivevjimmunityvjbutvjarevjst
illv j developingvjinvjthevjneonatalvjperiod.
5. ThevjtwovjmajorvjfunctionalvjclassesvjofvjeffectorvjTvjlymphocytesvjare:
a. HelpervjTvjlymphocytesvjandvjcytotoxicvjTvjlymphocytes
b. NaturalvjkillervjcellsvjandvjcytotoxicvjTvjlymphocytes
c. MemoryvjTvjcellsvjandvjeffectorvjTvjcells
d. Helpervjcellsvjandvjantigen-presentingvjcells
e. CytotoxicvjTvjlymphocytesvjandvjtargetvjcells
ANS:v j A
Tvjcellsvjcanvjbevjclassifiedvjintovjeffectorvjsubsetsvjthatvjperformvjdifferentvjeffectorvjfu
nctions.vjMostv j effectorvjTvjcellsvjarevjeithervjhelpervjTvjlymphocytes,vjwhichvjenhanc
evjthevjresponsesvjofvjotherv j immunevjcells,vjincludingvjphagocytesvjandvjBvjcells,vjto
vjinfections,vjorvjcytotoxicvjTvjlymphocytes,v j whichvjdirectlyvjkillvjinfectedvjcells.vjNa
turalvjkillervjcellsvjarevjnotvjTvjlymphocytes.
Antigen-presentingvjcellsvjusuallyvjarevjnotvjTvjcells.vjMemoryvjTvjcellsvjarevjnotvjeffectorvjTvjcells.
6. Whichvjofvjthevjfollowingvjcellvjtypesvjisvjrequiredvjforvjallvjadaptivevjhumoralvjimmunevjresponses?
a. Naturalvjkillervjcells
b. Dendriticvjcells
c. CytolyticvjTvjlymphocytes
d. Bvjlymphocytes
e. HelpervjTvjlymphocytes
ANS:v j D
Humoralvjimmunevjresponsesvjarevjantibody-
mediatedvjimmunevjresponses,vjandvjallvjantibodiesv j arevjmadevjbyvjBvjlymphocytesvja
ndvjnovjothervjcellvjtype.
DownloadvjAllvjChaptersvjHere:
https://www.stuvia.com/doc/3022302/
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