1|Page
AMLS EXAM - 2025 ACTUAL EXAM QUESTIONS AND CORRECT
DETAILED ANSWERS (VERIFIED ANSWERS) |ALREADY GRADED
A+||NEWEST VERSION, EXAMS OF NURSING
CD34 is a cell marker found on which type of cell?
a.
all myeloid cells
b.
all lymphoid cells
c.
early, undifferentiated cells
d.
mature, neoplastic B-cells
early, undifferentiated cells
Which of the following immunophenotypes is most consistent with cells in an acute T-cell
leukemia?
a.
CD2+, CD3+, CD7+
b.
CD34+, CD71+, CD14+
c.
HLA-DR, CD33+, CD13+
d.
CD19+, CD22+, CD20+
CD2+, CD3+, CD7+
Which of the following is NOT consistent with the morphology of the blasts seen in ALL-L2?
a.
Irregular nuclear shape with clefting and prominent nucleoli
b.
Variable amount of cytoplasm
c.
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Small, homogenous cell size
d.
All of the above are consistent with the morphology of the blasts seen in ALL-L2
Small, homogenous cell size
Which of the following selected monoclonal antibody panels would be used for the
identification of acute myeloid leukemias (all CD markers positive):
a.
HLA-DR, CD10, CD20
b.
CD2, CD3, CD7
c.
HLA-DR, CD13, CD33
d.
CD19, CD22, CD24
HLA-DR, CD13, CD33
Reed Sternberg cells, which have an "owl's eye" appearance, are associated with which of the
following disorders:
a.
Hodgkin Lymphoma
b.
Non-hodgkin Lymphoma
c.
Burkitt Lymphoma
d.
Mantle Cell Lymphoma
Hodgkin Lymphoma
True or False: Lymphomas are disorder that primary effect the peripheral blood and bone
marrow, while leukemias are disorders that primarily effect other hematopoietic tissues such as
the lymph nodes and spleen.
False
True or False: Acute leukemias are hematologic disorders that primarily occur in elderly patients
False
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Which non-enzymatic cytochemical stain reacts with the phospholipids in membranes of
primary and secondary granules?
a.
MPS
b.
SBB
c.
LAP
d.
PAS
SBB
Which of the following cytochemical stains would you choose to help you differentiate young,
immature lymphocytes from mature lymphocyte?
a.
Terminal deoxynucleotidyl transferase (Tdt)
b.
Non-specific Esterase (NSE)
c.
Tartrate Resistant Acid Phosphatase (TRAP)
d.
Toluidine Blue
Terminal deoxynucleotidyl transferase (Tdt)
Which of the following could be used as evidence to support a diagnosis of Chronic Lymphocytic
Leukemia (CLL)?
a.
Increased amounts of BCL2-protein which prevents apoptosis
b.
Presence of many prolymphocytes on the peripheral blood smear
c.
A positive TRAP stain result
d.
Immunophenotype CD2+, CD3+, CD10 (CALLA)+
Increased amounts of BCL2-protein which prevents apoptosis
True or False: An increased number of plasma cells is a common finding in the peripheral blood
of a multiple myeloma patient.
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False
Which of the following statements is NOT true regarding Hairy Cell Leukemia (HCL)?
a.
Panctyopenia with normocytic, normochromic anemia in the PB
b.
Positive tartrate resistant acid phosphatase (TRAP) staining
c.
Hairy cells are of the b-cell origin
d.
Hairy Cell Leukemia is seen almost exclusively in females
Hairy Cell Leukemia is seen almost exclusively in females
Which AML FAB subgroup is characterized by a "leukemic hiatus"?
a.
AML M1
b.
AML M2
c.
AML M3
d.
AML M4
AML M1
Which immunological class of lymphocyte represents the majority of Chronic Lymphocytic
Leukemia (CLL) cases?
a.
B lymphocytes
b.
T lymphocytes
c.
Reactive Lymphocytes
d.
Natural killer cells
AMLS EXAM - 2025 ACTUAL EXAM QUESTIONS AND CORRECT
DETAILED ANSWERS (VERIFIED ANSWERS) |ALREADY GRADED
A+||NEWEST VERSION, EXAMS OF NURSING
CD34 is a cell marker found on which type of cell?
a.
all myeloid cells
b.
all lymphoid cells
c.
early, undifferentiated cells
d.
mature, neoplastic B-cells
early, undifferentiated cells
Which of the following immunophenotypes is most consistent with cells in an acute T-cell
leukemia?
a.
CD2+, CD3+, CD7+
b.
CD34+, CD71+, CD14+
c.
HLA-DR, CD33+, CD13+
d.
CD19+, CD22+, CD20+
CD2+, CD3+, CD7+
Which of the following is NOT consistent with the morphology of the blasts seen in ALL-L2?
a.
Irregular nuclear shape with clefting and prominent nucleoli
b.
Variable amount of cytoplasm
c.
,2|Page
Small, homogenous cell size
d.
All of the above are consistent with the morphology of the blasts seen in ALL-L2
Small, homogenous cell size
Which of the following selected monoclonal antibody panels would be used for the
identification of acute myeloid leukemias (all CD markers positive):
a.
HLA-DR, CD10, CD20
b.
CD2, CD3, CD7
c.
HLA-DR, CD13, CD33
d.
CD19, CD22, CD24
HLA-DR, CD13, CD33
Reed Sternberg cells, which have an "owl's eye" appearance, are associated with which of the
following disorders:
a.
Hodgkin Lymphoma
b.
Non-hodgkin Lymphoma
c.
Burkitt Lymphoma
d.
Mantle Cell Lymphoma
Hodgkin Lymphoma
True or False: Lymphomas are disorder that primary effect the peripheral blood and bone
marrow, while leukemias are disorders that primarily effect other hematopoietic tissues such as
the lymph nodes and spleen.
False
True or False: Acute leukemias are hematologic disorders that primarily occur in elderly patients
False
,3|Page
Which non-enzymatic cytochemical stain reacts with the phospholipids in membranes of
primary and secondary granules?
a.
MPS
b.
SBB
c.
LAP
d.
PAS
SBB
Which of the following cytochemical stains would you choose to help you differentiate young,
immature lymphocytes from mature lymphocyte?
a.
Terminal deoxynucleotidyl transferase (Tdt)
b.
Non-specific Esterase (NSE)
c.
Tartrate Resistant Acid Phosphatase (TRAP)
d.
Toluidine Blue
Terminal deoxynucleotidyl transferase (Tdt)
Which of the following could be used as evidence to support a diagnosis of Chronic Lymphocytic
Leukemia (CLL)?
a.
Increased amounts of BCL2-protein which prevents apoptosis
b.
Presence of many prolymphocytes on the peripheral blood smear
c.
A positive TRAP stain result
d.
Immunophenotype CD2+, CD3+, CD10 (CALLA)+
Increased amounts of BCL2-protein which prevents apoptosis
True or False: An increased number of plasma cells is a common finding in the peripheral blood
of a multiple myeloma patient.
, 4|Page
False
Which of the following statements is NOT true regarding Hairy Cell Leukemia (HCL)?
a.
Panctyopenia with normocytic, normochromic anemia in the PB
b.
Positive tartrate resistant acid phosphatase (TRAP) staining
c.
Hairy cells are of the b-cell origin
d.
Hairy Cell Leukemia is seen almost exclusively in females
Hairy Cell Leukemia is seen almost exclusively in females
Which AML FAB subgroup is characterized by a "leukemic hiatus"?
a.
AML M1
b.
AML M2
c.
AML M3
d.
AML M4
AML M1
Which immunological class of lymphocyte represents the majority of Chronic Lymphocytic
Leukemia (CLL) cases?
a.
B lymphocytes
b.
T lymphocytes
c.
Reactive Lymphocytes
d.
Natural killer cells
