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ATI PHARMACOLOGY NURSING FUNDAMENTALS PROCTORED 2025,
NURSING PHARMACOLOGY EXAM, ATI DRUG CLASSIFICATIONS, SAFE
MEDICATION PRACTICES, ATI PHARMACOLOGY QUESTIONS, VERIFIED
ATI ANSWERS, NURSING EXAM PREP, EXAMS OF NURSING
A nurse is preparing to administer an IM dose of penicillin to a client who has a new
prescription. The client states she took penicillin 3 years ago and developed a rash. Which of the
following actions should the nurse take?
A. Administer the prescribed dose.
B. Withhold the medication.
C. Ask the provider to change the prescription to an oral form.
D.Administer an oral antihistamine at the same time - ANSWER-B. Withhold the medication.
(The nurse should withhold the medication and notify the provider of the client's previous
reaction to penicillin so that an alternative antibiotic can be prescribed. Allergic reactions to
penicillin can range from mild to severe anaphylaxis, and prior sensitization should be reported
to the provider.)
A nurse is providing discharge instructions for a client who has a new prescription for an
antihypertensive medication. Which of the following statements should the nurse give?
A. "Be sure to limit your potassium intake while taking the medication."
B. "You should check your blood pressure every 8 hours while taking this medication."
C. "Your medication dosage will be increased if you develop tachycardia."
D. "Change positions slowly when you move from sitting to standing." - ANSWER-D. "Change
positions slowly when you move from sitting to standing."
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(Orthostatic hypotension is a common adverse effect of antihypertensive medications. The
client should move slowly to a sitting or standing position and should be taught to sit or lie
down if lightheadedness or dizziness occurs)
A nurse is reviewing a client's health record and notes that the client experiences permanent
extrapyramidal effects caused by a previous medication. The nurse should recognize that the
medication affected which of the following systems in the client?
A. Cardiovascular
B. Immune
C. Central nervous
D. Gastrointestinal - ANSWER-C. Central nervous
(The nurse should realize that extrapyramidal effects are movement disorders that can be
caused by a number of central nervous system medications, such as typical antipsychotic
medications)
A nurse is caring for a client who is taking oral Oxycodone The client states he is also taking
Ibuprofen in three recommended doses daily. The nurse should identify that an interaction
between these two medications will cause which of the following findings?
A. A decrease in serum levels of ibuprofen, possibly leading to a need for increased doses of this
medication
B. A decrease in serum levels of oxycodone, possibly leading to a need for increased doses of
this medication
C. An increase in the expected therapeutic effect of both medications
D. An increase in expected adverse effects for both medications - ANSWER-C. An increase in the
expected therapeutic effect of both medications
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(These medications work together to increase the pain-relieving effects of both medications.
Oxycodone is a narcotic analgesic, and ibuprofen is an NSAID. They work by different
mechanisms, but pain is better relieved when they are taken together)
A nurse is preparing to administer medications to a 4-month-old infant. Which of the following
pharmacokinetic principles should the nurse consider when administering medications to this
client? (Select all that apply.)
A. Infants have a more rapid gastric emptying time.
B. Infants have immature liver function.
C. Infants' blood-brain barrier is poorly developed.
D. Infants have an increased ability to absorb topical medications.
E. Infants have an increased number of protein-binding sites. - ANSWER-B. Infants have
immature liver function.
C. Infants' blood-brain barrier is poorly developed.
D. Infants have an increased ability to absorb topical medications.
(B. Infants have immature liver function until 1 year of age. The nurse should administer
medications the liver metabolizes in smaller dosages.
C. Infants have a poorly developed blood-brain barrier, which places them at risk for adverse
effects from medications that pass through the blood-brain barrier. The nurse should administer
these medications in smaller dosages.
D. Because infants have more blood flowing to the skin and their skin is thin, their medication
absorption is increased, making them prone to toxicity from topical medications)
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A provider prescribes phenobarbital for a client who has a seizure disorder. The medication has
a long half-life of 4 days. How many times per day should the nurse expect to administer this
medication?
A. One
B. Two
C. Three
D. Four - ANSWER-A. One
(Medications with long half-lives remain at their therapeutic levels between doses for long
periods of time. The nurse should expect to administer this medication once a day.)
A staff educator is reviewing medication dosages and factors that influence medication
metabolism with a group of nurses at an in-service presentation. Which of the following factors
should the educator include as a reason to administer lower medication dosages? (Select all
that apply.)
A. Increased renal secretion
B. Increased medication-metabolizing enzymes
C. Liver failure
D. Peripheral vascular disease
E. Concurrent use of medication the same pathway metabolizes - ANSWER-C. Liver failure
E. Concurrent use of medication the same pathway metabolizes
C. Liver failure decreases metabolism and thus increases the concentration of a medication. This
requires decreasing the dosage.
ATI PHARMACOLOGY NURSING FUNDAMENTALS PROCTORED 2025,
NURSING PHARMACOLOGY EXAM, ATI DRUG CLASSIFICATIONS, SAFE
MEDICATION PRACTICES, ATI PHARMACOLOGY QUESTIONS, VERIFIED
ATI ANSWERS, NURSING EXAM PREP, EXAMS OF NURSING
A nurse is preparing to administer an IM dose of penicillin to a client who has a new
prescription. The client states she took penicillin 3 years ago and developed a rash. Which of the
following actions should the nurse take?
A. Administer the prescribed dose.
B. Withhold the medication.
C. Ask the provider to change the prescription to an oral form.
D.Administer an oral antihistamine at the same time - ANSWER-B. Withhold the medication.
(The nurse should withhold the medication and notify the provider of the client's previous
reaction to penicillin so that an alternative antibiotic can be prescribed. Allergic reactions to
penicillin can range from mild to severe anaphylaxis, and prior sensitization should be reported
to the provider.)
A nurse is providing discharge instructions for a client who has a new prescription for an
antihypertensive medication. Which of the following statements should the nurse give?
A. "Be sure to limit your potassium intake while taking the medication."
B. "You should check your blood pressure every 8 hours while taking this medication."
C. "Your medication dosage will be increased if you develop tachycardia."
D. "Change positions slowly when you move from sitting to standing." - ANSWER-D. "Change
positions slowly when you move from sitting to standing."
,2|Page
(Orthostatic hypotension is a common adverse effect of antihypertensive medications. The
client should move slowly to a sitting or standing position and should be taught to sit or lie
down if lightheadedness or dizziness occurs)
A nurse is reviewing a client's health record and notes that the client experiences permanent
extrapyramidal effects caused by a previous medication. The nurse should recognize that the
medication affected which of the following systems in the client?
A. Cardiovascular
B. Immune
C. Central nervous
D. Gastrointestinal - ANSWER-C. Central nervous
(The nurse should realize that extrapyramidal effects are movement disorders that can be
caused by a number of central nervous system medications, such as typical antipsychotic
medications)
A nurse is caring for a client who is taking oral Oxycodone The client states he is also taking
Ibuprofen in three recommended doses daily. The nurse should identify that an interaction
between these two medications will cause which of the following findings?
A. A decrease in serum levels of ibuprofen, possibly leading to a need for increased doses of this
medication
B. A decrease in serum levels of oxycodone, possibly leading to a need for increased doses of
this medication
C. An increase in the expected therapeutic effect of both medications
D. An increase in expected adverse effects for both medications - ANSWER-C. An increase in the
expected therapeutic effect of both medications
,3|Page
(These medications work together to increase the pain-relieving effects of both medications.
Oxycodone is a narcotic analgesic, and ibuprofen is an NSAID. They work by different
mechanisms, but pain is better relieved when they are taken together)
A nurse is preparing to administer medications to a 4-month-old infant. Which of the following
pharmacokinetic principles should the nurse consider when administering medications to this
client? (Select all that apply.)
A. Infants have a more rapid gastric emptying time.
B. Infants have immature liver function.
C. Infants' blood-brain barrier is poorly developed.
D. Infants have an increased ability to absorb topical medications.
E. Infants have an increased number of protein-binding sites. - ANSWER-B. Infants have
immature liver function.
C. Infants' blood-brain barrier is poorly developed.
D. Infants have an increased ability to absorb topical medications.
(B. Infants have immature liver function until 1 year of age. The nurse should administer
medications the liver metabolizes in smaller dosages.
C. Infants have a poorly developed blood-brain barrier, which places them at risk for adverse
effects from medications that pass through the blood-brain barrier. The nurse should administer
these medications in smaller dosages.
D. Because infants have more blood flowing to the skin and their skin is thin, their medication
absorption is increased, making them prone to toxicity from topical medications)
, 4|Page
A provider prescribes phenobarbital for a client who has a seizure disorder. The medication has
a long half-life of 4 days. How many times per day should the nurse expect to administer this
medication?
A. One
B. Two
C. Three
D. Four - ANSWER-A. One
(Medications with long half-lives remain at their therapeutic levels between doses for long
periods of time. The nurse should expect to administer this medication once a day.)
A staff educator is reviewing medication dosages and factors that influence medication
metabolism with a group of nurses at an in-service presentation. Which of the following factors
should the educator include as a reason to administer lower medication dosages? (Select all
that apply.)
A. Increased renal secretion
B. Increased medication-metabolizing enzymes
C. Liver failure
D. Peripheral vascular disease
E. Concurrent use of medication the same pathway metabolizes - ANSWER-C. Liver failure
E. Concurrent use of medication the same pathway metabolizes
C. Liver failure decreases metabolism and thus increases the concentration of a medication. This
requires decreasing the dosage.
