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1. What is population genetics? study of processes that change al-
lele and genotype frequencies in
populations
2. What is a population? group of individuals of same
species living in same area -->
interbreed, producing fertile ott-
spring
3. What are the 4 agents of evolution? 1. Mutation modifies allele fre-
quencies by continually introduc-
ing new alleles
2. Genetic drift causes allele fre-
quencies to change randomly
3. Gene flow individuals leave
one population, join another and
breed
4. Natural Selection increases fre-
quency of alleles that contribute to
reproductive success in a partic-
ular environment --> only natural
selection produces adaptation
4. What is the Hardy-Weinberg theorem? In the absence of drift, selection,
migration and mutation, the allele
frequencies of a population (at
the genetic locus) will not change
from one generation to the next.
5. What is the Hardy Weinberg equilibrium? When alleles transmitted via
meiosis and random combination
of gametes, allele frequencies do
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not change. Allele frequencies for
the next generation: freq A is still p
and freq a is still q. If frequencies
conform to predictions, the fre-
quencies are in Hardy Weinberg
Equilibrium
6. Why is the HW theorem important for under- It provides mathematical proof
standing evolutionary change? that evolution will not occur in
the absence of selection, drift, mi-
gration or mutation. By explicitly
delineating the conditions under
which allele frequencies do not
change, the theorem serves as a
useful null hypothesis for studying
the ways that allele frequencies do
change. By studying how popula-
tions deviate from HW equilibri-
um, we can learn about the mech-
anisms of evolution
7. What is the gene pool? gene pool - all parents in popula-
tion - all possible gametes in gene
pool
8. How is the HW theorem based on the gene pool Allele frequencies for the next
concept? generation:
freq A is still p
freq a is still q
The allele frequencies have not
changed from generation to the
next
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9. What are the assumptions of HWE and impor- Organisms are diploid
tance No overlapping generations
No mutations
Population is infinitely large
- no random allele frequency
changes
No gene flow - no new alleles
added by immigration or lost by
emigration
No natural selection - all members
of the parental population gener-
ation contribute equal numbers of
gametes to gene pool ( no ditter-
ence in survival or reproduction)
Mating is random with respect to
genotypes - gametes from gene
pol combine at random (all geno-
type combinations equally likely)
10. How does the HW theorem represent a testable Natural selection, genetic drift,
null hypothesis? gene flow and mutation can cause
allele frequencies to change over
time, the HW principle allows us
to ask if one (or more) of these
are occurring --> acts as a null hy-
pothesis.
Null hypothesis: specifies what
should be seen if the hypothesis
being tested is not correct
11. What is p+q=1 There are only 2 alleles for this
gene, so allele A(p) and a(q)