Nurs 660 Exam 1- |! |! |! |!
Antipsychotic Medications |! |!
with accurate solutions |! |!
Three classes of classical/ FGA - Correct answer ✔
|! |! |! |! |! |! |! |!
1) phenothiazines
|!
2) thioxanthenes
|!
3) butyrophenones
|!
prototypical SGA - Correct answer ✔clozapine |! |! |! |! |!
chlorpromazine (THORAZINE) - Correct answer ✔-lowest potentcy |! |! |! |! |! |! |!
antipsychotic |!
-significant alpha-1 adrenergic blockade --> sedation, hypotention
|! |! |! |! |! |!
-DA blockage in basal ganglia --> EPS
|! |! |! |! |! |!
classic example of butyrophenone (FGA) - Correct answer ✔haloperidol
|! |! |! |! |! |! |! |! |!
(HALDOL)
haloperiol (HALDOL) - Correct answer ✔-potent D2 blockade --> acute
|! |! |! |! |! |! |! |! |! |!
treatment of psychosis |! |!
-high EPS, sedation
|! |!
, -less weight gain, anticholinergic effects, hypotension
|! |! |! |! |!
drug usually used to treat acute psychotic episodes - Correct answer
|! |! |! |! |! |! |! |! |! |! |!
✔haloperidol (HALDOL) |!
first generation antipsychotics block what receptors? - Correct answer ✔block
|! |! |! |! |! |! |! |! |!
D2 receptors- therapeutic efficacy correlates with D2 blockade
|! |! |! |! |! |! |! |!
which antipsychotics alleviate mainly positive symptoms, and carry higher
|! |! |! |! |! |! |! |! |!
risk of EPS and tardive dyskinesia with high doses and long-term use -
|! |! |! |! |! |! |! |! |! |! |! |! |!
Correct answer ✔first generation/ typical antipsychotics
|! |! |! |! |!
-haloperidol
-chlorpromazine
SGA have greater affinity for which receptors - Correct answer ✔-affinity for
|! |! |! |! |! |! |! |! |! |! |! |!
serotonin >> dopamine |! |!
SGA characteristics - Correct answer ✔-block more than 1 type of receptor
|! |! |! |! |! |! |! |! |! |! |!
-help positive and negative sxs
|! |! |! |!
-improve cognitive fx |! |!
-less EPS/TD |!
SGA/ atypical (5+) - Correct answer ✔1) clozapine (CLOZARIL)
|! |! |! |! |! |! |! |!
2) risperidone (RIPERDAL)
|! |!
Antipsychotic Medications |! |!
with accurate solutions |! |!
Three classes of classical/ FGA - Correct answer ✔
|! |! |! |! |! |! |! |!
1) phenothiazines
|!
2) thioxanthenes
|!
3) butyrophenones
|!
prototypical SGA - Correct answer ✔clozapine |! |! |! |! |!
chlorpromazine (THORAZINE) - Correct answer ✔-lowest potentcy |! |! |! |! |! |! |!
antipsychotic |!
-significant alpha-1 adrenergic blockade --> sedation, hypotention
|! |! |! |! |! |!
-DA blockage in basal ganglia --> EPS
|! |! |! |! |! |!
classic example of butyrophenone (FGA) - Correct answer ✔haloperidol
|! |! |! |! |! |! |! |! |!
(HALDOL)
haloperiol (HALDOL) - Correct answer ✔-potent D2 blockade --> acute
|! |! |! |! |! |! |! |! |! |!
treatment of psychosis |! |!
-high EPS, sedation
|! |!
, -less weight gain, anticholinergic effects, hypotension
|! |! |! |! |!
drug usually used to treat acute psychotic episodes - Correct answer
|! |! |! |! |! |! |! |! |! |! |!
✔haloperidol (HALDOL) |!
first generation antipsychotics block what receptors? - Correct answer ✔block
|! |! |! |! |! |! |! |! |!
D2 receptors- therapeutic efficacy correlates with D2 blockade
|! |! |! |! |! |! |! |!
which antipsychotics alleviate mainly positive symptoms, and carry higher
|! |! |! |! |! |! |! |! |!
risk of EPS and tardive dyskinesia with high doses and long-term use -
|! |! |! |! |! |! |! |! |! |! |! |! |!
Correct answer ✔first generation/ typical antipsychotics
|! |! |! |! |!
-haloperidol
-chlorpromazine
SGA have greater affinity for which receptors - Correct answer ✔-affinity for
|! |! |! |! |! |! |! |! |! |! |! |!
serotonin >> dopamine |! |!
SGA characteristics - Correct answer ✔-block more than 1 type of receptor
|! |! |! |! |! |! |! |! |! |! |!
-help positive and negative sxs
|! |! |! |!
-improve cognitive fx |! |!
-less EPS/TD |!
SGA/ atypical (5+) - Correct answer ✔1) clozapine (CLOZARIL)
|! |! |! |! |! |! |! |!
2) risperidone (RIPERDAL)
|! |!
