PHARMACOLOGY EVOLVE HESI REAL EXAM
PHARMACOLOGY EVOLVE HESI REAL
EXAM 2025 LATEST UPDATE WITH
COMPLETE ACCURATE 150
QUESTIONS AND CORRECT
ANSWERS WITH RATIONALES
(VERIFIED ANSWERS) |ALREADY
GRADED A+
1|Page
, PHARMACOLOGY EVOLVE HESI REAL EXAM
The practical nurse (PN) is unable to arouse a client who is receiving meperidine (Demerol) for
postoperative pain. The client is stuporous, has constricted pupils, and a respiratory rate of 8
breaths/minute. Which PRN prescription should the PN give the client?
A) Naloxone (Narcan).
B) Promethazine (Phenergan).
C) Metoclopramide (Reglan).
D) Bethanechol (Urecholine). - ANSWER-A) Naloxone (Narcan).
Feedback:
Narcan (A) is an opioid antagonist and should be administered to reverse the effects of a
Demerol, an opioid, overdose. (B, C, and D) are common postoperative PRN prescriptions but
are not indicated for narcotic overdose.
On which therapeutic action should the practical nurse (PN) base an explanation to a client who
is receiving a cardiac glycoside?
A) Decreased cardiac output.
B) Increased renal perfusion.
C) Decreased rate of contraction.
D) Increased blood volume. - ANSWER-C) Decreased rate of contraction.
Feedback:
Cardiac glycosides increase the force of cardiac contraction (inotropy) and decrease the heart
rate (chronotropy) (C) by decreasing the speed of conduction through the heart (dromotropy).
(A, B, and D) are incorrect.
A client with type 1 diabetes mellitus received an early AM dose of regular insulin per sliding
scale. At 10:00 AM, the practical nurse (PN) should report which signs indicative of
hypoglycemia?
A) Urticaria and rash.
B) Nausea and diarrhea.
C) Irritability and confusion.
2|Page
, PHARMACOLOGY EVOLVE HESI REAL EXAM
D) Fruity, acetone odor to the breath. - ANSWER-C) Irritability and confusion.
Feedback:
Irritability and confusion (C) are early signs of hypoglycemia. (A, B, and D) are not signs of
hypoglycemia.
Which prescription should the practical nurse (PN) administer for a client who is experiencing an
anaphylactic reaction to an antibiotic?
A) Ephedra (ma-huang).
B) Epinephrine (Adrenalin).
C) Phenylephrin (Neo-Synephrine).
D) Fexofenadine with pseudoephedrine (Allegra D). - ANSWER-B) Epinephrine (Adrenalin).
Feedback:
Epinephrine (Adrenalin), a potent sympathomimetic, is the drug of choice for the treatment of
anaphylaxis (B). (A, C, and D) are not used for an acute immunololgical dysfunction that causes
cardiovascular effects.
An older adult client receives a prescription for hydrochlorothiazide (HydroDIURIL), a thiazide
diuretic for the treatment of heart failure. Which side effect(s) should the practical nurse
reinforce with the client? (Select all that apply.)
A) Constipation.
B) Fatigue.
C) Edema.
D) Nausea.
E) Dehydration.
F) Blurred vision. - ANSWER-B) Fatigue.
E) Dehydration.
Feedback:
3|Page
, PHARMACOLOGY EVOLVE HESI REAL EXAM
Hydrochlorothiazide (HydroDIURIL), a thiazide diuretic, reduces blood pressure by reducing
blood volume and reducing arterial resistance. Adverse effects of thiazides include hypokalemia,
fatigue (B), dehydration (E), hyperglycemia, and hyperuricemia. Although (A, C, D and F) may be
associated with aging or other pathology, they are not side effects commonly associated with
HydroDIURIL.
A client who returns from surgery for bowel resection complains of severe pain around the
incision. Which assessment is most important for the practical nurse (PN) to obtain prior to the
administration of morphine sulfate?
A) Rate of respirations.
B) Core temperature.
C) Appearance of the incision.
D) Presence of bowel sounds. - ANSWER-A) Rate of respirations.
Feedback:
Opioids cause respiratory depression, so the respiratory rate (A) should be assessed prior to
administration of morphine sulfate. (B, C, and D) do not address the concept of medication
safety.
A client is receiving the third course of 5-fluorouracil (5FU) therapy for a tumor of the liver.
Which action should the practical nurse implement to reduce the client's risk for stomatitis?
A) Use commercial oral products to reduce the risk of oral infections.
B) Observe for black, tarry stools or bleeding ulcerations.
C) Increase intake of foods containing fiber and citric acid.
D) Examine mouth daily for bleeding, white spots, and ulcerations. - ANSWER-D) Examine
mouth daily for bleeding, white spots, and ulcerations.
Feedback:
5-fluorouracil (5FU) is an antimetabolite, antineoplastic agent that causes sloughing of the rapid
proliferating epithelial cells of the oral mucosa causing ulceration, bleeding, and oral candidiasis
(thrush). Daily examination of the oral mucosa (D) should be implemented to identify signs of
stomatitis, such as white spots, ulcerations, and bleeding of the mouth, so early intervention
4|Page
PHARMACOLOGY EVOLVE HESI REAL
EXAM 2025 LATEST UPDATE WITH
COMPLETE ACCURATE 150
QUESTIONS AND CORRECT
ANSWERS WITH RATIONALES
(VERIFIED ANSWERS) |ALREADY
GRADED A+
1|Page
, PHARMACOLOGY EVOLVE HESI REAL EXAM
The practical nurse (PN) is unable to arouse a client who is receiving meperidine (Demerol) for
postoperative pain. The client is stuporous, has constricted pupils, and a respiratory rate of 8
breaths/minute. Which PRN prescription should the PN give the client?
A) Naloxone (Narcan).
B) Promethazine (Phenergan).
C) Metoclopramide (Reglan).
D) Bethanechol (Urecholine). - ANSWER-A) Naloxone (Narcan).
Feedback:
Narcan (A) is an opioid antagonist and should be administered to reverse the effects of a
Demerol, an opioid, overdose. (B, C, and D) are common postoperative PRN prescriptions but
are not indicated for narcotic overdose.
On which therapeutic action should the practical nurse (PN) base an explanation to a client who
is receiving a cardiac glycoside?
A) Decreased cardiac output.
B) Increased renal perfusion.
C) Decreased rate of contraction.
D) Increased blood volume. - ANSWER-C) Decreased rate of contraction.
Feedback:
Cardiac glycosides increase the force of cardiac contraction (inotropy) and decrease the heart
rate (chronotropy) (C) by decreasing the speed of conduction through the heart (dromotropy).
(A, B, and D) are incorrect.
A client with type 1 diabetes mellitus received an early AM dose of regular insulin per sliding
scale. At 10:00 AM, the practical nurse (PN) should report which signs indicative of
hypoglycemia?
A) Urticaria and rash.
B) Nausea and diarrhea.
C) Irritability and confusion.
2|Page
, PHARMACOLOGY EVOLVE HESI REAL EXAM
D) Fruity, acetone odor to the breath. - ANSWER-C) Irritability and confusion.
Feedback:
Irritability and confusion (C) are early signs of hypoglycemia. (A, B, and D) are not signs of
hypoglycemia.
Which prescription should the practical nurse (PN) administer for a client who is experiencing an
anaphylactic reaction to an antibiotic?
A) Ephedra (ma-huang).
B) Epinephrine (Adrenalin).
C) Phenylephrin (Neo-Synephrine).
D) Fexofenadine with pseudoephedrine (Allegra D). - ANSWER-B) Epinephrine (Adrenalin).
Feedback:
Epinephrine (Adrenalin), a potent sympathomimetic, is the drug of choice for the treatment of
anaphylaxis (B). (A, C, and D) are not used for an acute immunololgical dysfunction that causes
cardiovascular effects.
An older adult client receives a prescription for hydrochlorothiazide (HydroDIURIL), a thiazide
diuretic for the treatment of heart failure. Which side effect(s) should the practical nurse
reinforce with the client? (Select all that apply.)
A) Constipation.
B) Fatigue.
C) Edema.
D) Nausea.
E) Dehydration.
F) Blurred vision. - ANSWER-B) Fatigue.
E) Dehydration.
Feedback:
3|Page
, PHARMACOLOGY EVOLVE HESI REAL EXAM
Hydrochlorothiazide (HydroDIURIL), a thiazide diuretic, reduces blood pressure by reducing
blood volume and reducing arterial resistance. Adverse effects of thiazides include hypokalemia,
fatigue (B), dehydration (E), hyperglycemia, and hyperuricemia. Although (A, C, D and F) may be
associated with aging or other pathology, they are not side effects commonly associated with
HydroDIURIL.
A client who returns from surgery for bowel resection complains of severe pain around the
incision. Which assessment is most important for the practical nurse (PN) to obtain prior to the
administration of morphine sulfate?
A) Rate of respirations.
B) Core temperature.
C) Appearance of the incision.
D) Presence of bowel sounds. - ANSWER-A) Rate of respirations.
Feedback:
Opioids cause respiratory depression, so the respiratory rate (A) should be assessed prior to
administration of morphine sulfate. (B, C, and D) do not address the concept of medication
safety.
A client is receiving the third course of 5-fluorouracil (5FU) therapy for a tumor of the liver.
Which action should the practical nurse implement to reduce the client's risk for stomatitis?
A) Use commercial oral products to reduce the risk of oral infections.
B) Observe for black, tarry stools or bleeding ulcerations.
C) Increase intake of foods containing fiber and citric acid.
D) Examine mouth daily for bleeding, white spots, and ulcerations. - ANSWER-D) Examine
mouth daily for bleeding, white spots, and ulcerations.
Feedback:
5-fluorouracil (5FU) is an antimetabolite, antineoplastic agent that causes sloughing of the rapid
proliferating epithelial cells of the oral mucosa causing ulceration, bleeding, and oral candidiasis
(thrush). Daily examination of the oral mucosa (D) should be implemented to identify signs of
stomatitis, such as white spots, ulcerations, and bleeding of the mouth, so early intervention
4|Page
