PHARMACOLOGY EVOLVE HESI REAL EXAM
PHARMACOLOGY EVOLVE HESI REAL EXAM 2025
LATEST UPDATE WITH COMPLETE ACCURATE
QUESTIONS AND CORRECT ANSWERS WITH
RATIONALES (VERIFIED ANSWERS) |ALREADY
GRADED A+
1|Page
, PHARMACOLOGY EVOLVE HESI REAL EXAM
The health care provider prescribes the H2 antagonist famotidine, 20 mg PO in the morning and
at bedtime. Which statement regarding the action of H2 antagonists offers the correct rationale
for administering the medication at bedtime?
A. Gastric acid secreted at night is buffered, preventing pepsin formation.
B. Hydrochloric acid secreted during the night is blocked.
C. The drug relaxes stomach muscles at night to reduce acid.
D. Ingestion of the medication at night offers a sedative effect, promoting sleep. - ANSWER-B.
Hydrochloric acid secreted during the night is blocked.
H2 antagonists act on the parietal cells to inhibit gastric secretion. Some gastric secretion occurs
all the time, even when the stomach is empty, unless medications are taken to inhibit this
action. Options C and D are not actions of famotidine. Option A is the action of antacids.
Antacids do not affect healing or prevent the recurrence of ulcers; they merely provide
symptomatic relief. Knowing the difference between H2 antagonists and antacids is important
when teaching clients.
The nurse is preparing to administer the disease-modifying antirheumatic drug (DMARD)
methotrexate to a client diagnosed with rheumatoid arthritis. Which intervention is most
important to implement prior to administering this medication?
A. Assess the client's liver function test results.
B. Monitor the client's intake and output.
C. Have another nurse check the prescription.
D. Assess the client's oral mucosa. - ANSWER-C. Have another nurse check the prescription.
Double-checking the prescription is an important intervention because death can occur from an
overdose. This medication is administered weekly and in low doses for rheumatoid arthritis and
should not be confused with administration of the drug as a chemotherapeutic agent. Options A
2|Page
, PHARMACOLOGY EVOLVE HESI REAL EXAM
and B are appropriate interventions for those who are receiving this drug, but they are not the
most important interventions. Stomatitis is an expected side effect of this medication.
A female client with myasthenia gravis is taking a cholinesterase inhibitor and asks the nurse
what can be done to remedy her fatigue and difficulty swallowing. What action should the nurse
implement?
A. Explore a plan for development of coping strategies for the symptoms with the client.
B. Explain to the client that the dosage is too high, so she should skip every other dose of
medication.
C. Advise the client to contact her health care provider because of the development of
tolerance to the medication.
D. Develop a teaching plan for the client to self-adjust the dose of medication in response to
symptoms. - ANSWER-D. Develop a teaching plan for the client to self-adjust the dose of
medication in response to symptoms.
Maintaining optimal dosage for cholinesterase inhibitors can be challenging for clients with
myasthenia gravis. Clients should be taught to recognize signs of overmedication and
undermedication so that they can modify the dosage themselves based on a prescribed sliding
scale. Options A, B, and C do not adequately address the client's concerns.
A female client is receiving tetracycline for acne. Which client teaching should the nurse
include?
A. Oral contraceptives may not be effective.
B. Drinking cranberry juice will promote healing.
C. Breast tenderness may occur as a side effect.
D. The urine will turn a red-orange color. - ANSWER-A. Oral contraceptives may not be effective.
3|Page
, PHARMACOLOGY EVOLVE HESI REAL EXAM
Certain antibiotics, such as tetracycline, decrease the effectiveness of oral contraceptives.
Options B, C, and D do not convey accurate information related to client teaching about this
medication.
A client who is experiencing an acute attack of gouty arthritis is prescribed colchicine USP, 1 mg
PO daily. Which information is most important for the nurse to provide the client?
A. Take the medication with meals.
B. Limit fluid intake until the attack subsides.
C. Stop the medication when the pain resolves.
D. Report any vomiting to the clinic. - ANSWER-D. Report any vomiting to the clinic.
The client should be instructed to report signs of colchicine toxicity, such as nausea, diarrhea,
vomiting, and/or abdominal pain, to the health care provider. Food inhibits the absorption of
colchicine when ingested concurrently. Limited fluid intake decreases the excretion of the uric
acid crystals, which contributes to painful attacks. Typically, a client should remain on a daily
dose of colchicine to decrease the number and severity of acute attacks, so stopping the
medication after the pain resolves is not indicated.
Amoxicillin, 500 mg PO every 8 hours, is prescribed for a client with an infection. The drug is
available in a suspension of 125 mg/5 mL. How many milliliters should the nurse administer
with each dose?
A. 10
B. 15
C. 20
D. 25 - ANSWER-C. 20
500 mg/x mL = 125 mg/5 mL
4|Page
PHARMACOLOGY EVOLVE HESI REAL EXAM 2025
LATEST UPDATE WITH COMPLETE ACCURATE
QUESTIONS AND CORRECT ANSWERS WITH
RATIONALES (VERIFIED ANSWERS) |ALREADY
GRADED A+
1|Page
, PHARMACOLOGY EVOLVE HESI REAL EXAM
The health care provider prescribes the H2 antagonist famotidine, 20 mg PO in the morning and
at bedtime. Which statement regarding the action of H2 antagonists offers the correct rationale
for administering the medication at bedtime?
A. Gastric acid secreted at night is buffered, preventing pepsin formation.
B. Hydrochloric acid secreted during the night is blocked.
C. The drug relaxes stomach muscles at night to reduce acid.
D. Ingestion of the medication at night offers a sedative effect, promoting sleep. - ANSWER-B.
Hydrochloric acid secreted during the night is blocked.
H2 antagonists act on the parietal cells to inhibit gastric secretion. Some gastric secretion occurs
all the time, even when the stomach is empty, unless medications are taken to inhibit this
action. Options C and D are not actions of famotidine. Option A is the action of antacids.
Antacids do not affect healing or prevent the recurrence of ulcers; they merely provide
symptomatic relief. Knowing the difference between H2 antagonists and antacids is important
when teaching clients.
The nurse is preparing to administer the disease-modifying antirheumatic drug (DMARD)
methotrexate to a client diagnosed with rheumatoid arthritis. Which intervention is most
important to implement prior to administering this medication?
A. Assess the client's liver function test results.
B. Monitor the client's intake and output.
C. Have another nurse check the prescription.
D. Assess the client's oral mucosa. - ANSWER-C. Have another nurse check the prescription.
Double-checking the prescription is an important intervention because death can occur from an
overdose. This medication is administered weekly and in low doses for rheumatoid arthritis and
should not be confused with administration of the drug as a chemotherapeutic agent. Options A
2|Page
, PHARMACOLOGY EVOLVE HESI REAL EXAM
and B are appropriate interventions for those who are receiving this drug, but they are not the
most important interventions. Stomatitis is an expected side effect of this medication.
A female client with myasthenia gravis is taking a cholinesterase inhibitor and asks the nurse
what can be done to remedy her fatigue and difficulty swallowing. What action should the nurse
implement?
A. Explore a plan for development of coping strategies for the symptoms with the client.
B. Explain to the client that the dosage is too high, so she should skip every other dose of
medication.
C. Advise the client to contact her health care provider because of the development of
tolerance to the medication.
D. Develop a teaching plan for the client to self-adjust the dose of medication in response to
symptoms. - ANSWER-D. Develop a teaching plan for the client to self-adjust the dose of
medication in response to symptoms.
Maintaining optimal dosage for cholinesterase inhibitors can be challenging for clients with
myasthenia gravis. Clients should be taught to recognize signs of overmedication and
undermedication so that they can modify the dosage themselves based on a prescribed sliding
scale. Options A, B, and C do not adequately address the client's concerns.
A female client is receiving tetracycline for acne. Which client teaching should the nurse
include?
A. Oral contraceptives may not be effective.
B. Drinking cranberry juice will promote healing.
C. Breast tenderness may occur as a side effect.
D. The urine will turn a red-orange color. - ANSWER-A. Oral contraceptives may not be effective.
3|Page
, PHARMACOLOGY EVOLVE HESI REAL EXAM
Certain antibiotics, such as tetracycline, decrease the effectiveness of oral contraceptives.
Options B, C, and D do not convey accurate information related to client teaching about this
medication.
A client who is experiencing an acute attack of gouty arthritis is prescribed colchicine USP, 1 mg
PO daily. Which information is most important for the nurse to provide the client?
A. Take the medication with meals.
B. Limit fluid intake until the attack subsides.
C. Stop the medication when the pain resolves.
D. Report any vomiting to the clinic. - ANSWER-D. Report any vomiting to the clinic.
The client should be instructed to report signs of colchicine toxicity, such as nausea, diarrhea,
vomiting, and/or abdominal pain, to the health care provider. Food inhibits the absorption of
colchicine when ingested concurrently. Limited fluid intake decreases the excretion of the uric
acid crystals, which contributes to painful attacks. Typically, a client should remain on a daily
dose of colchicine to decrease the number and severity of acute attacks, so stopping the
medication after the pain resolves is not indicated.
Amoxicillin, 500 mg PO every 8 hours, is prescribed for a client with an infection. The drug is
available in a suspension of 125 mg/5 mL. How many milliliters should the nurse administer
with each dose?
A. 10
B. 15
C. 20
D. 25 - ANSWER-C. 20
500 mg/x mL = 125 mg/5 mL
4|Page
