NBME Cbse EXAM WITH FREQUENTLY TESTED
QUESTIONS AND RATIONALE
ALREADY GRADED A+ For GUARANTEED PASS
LATEST UPDATE 2025.
Benztropine (Cogentin) - CORRECT ANSWER An antimuscarinic used to treat
Parkinson's disease "park my benz"
Acetylcholinesterase inhibitor (AChE inhibitors) effects - CORRECT ANSWER it is an indirect
muscarinic agonist so it will produce PNS like control (SLUD-BBAM)
Malathion - CORRECT ANSWER an organophosphate insecticide that acts as an
acetylcholinesterase inhibitor
Sarin - CORRECT ANSWER an organophosphate nerve gas that acts as an
acetylcholinesterase inhibitor
Antimuscarninics (muscarinic antagonists) - CORRECT ANSWER Atropine
Glycopyrrolate
Tropicamide
Ipratropium
Darifenacin
Scopolamine
Benztropine
Atropine - CORRECT ANSWER An antimuscarinic used to treat organohosphate
poisoning bradycardia, preop/surgery to dry secretions (can produce CYCLOPLEGIA)
produces opposite of SLUD-BBAM
Pralidoxime - CORRECT ANSWER used to treat organophosphate poisoning
Glycopyrrolate - CORRECT ANSWER An antimuscarinic used for preop/surgery to
dry secretions
Tropicamide - CORRECT ANSWER An antimuscarinic used for eye exams (causes
mydriatic eyes)
Ipratropium (Atrovent) - CORRECT ANSWER An antimuscarinic used to treat asthma
"I pray I can breathe soon"
Darifenacin (Enablex) - CORRECT ANSWER An antimuscarinic used to treat
overactive bladder
Scopolamine - CORRECT ANSWER An antimuscarinic used to treat motion sickness
,NBME Cbse EXAM WITH FREQUENTLY TESTED
QUESTIONS AND RATIONALE
ALREADY GRADED A+ For GUARANTEED PASS
LATEST UPDATE 2025.
Acetylcholinesterase Restorative - CORRECT ANSWER Pralidoxime- which is used to
treat organophosphate poisoning especially nerve gasses
Acetylcholinesterase Restorative effect - CORRECT ANSWER treats
acetylcholinesterase inhibition so it restores SNS like control (opposite of SLUD-
BBAM)
Acetylcholinesterase inhibitors (AChE inhibitors) - CORRECT ANSWER
Pyridostigmine Neostigmine
Edrophonium
Donepezil
Rivastigmine
Tacrine
(Malathion)
(Sarin)
First 3 are for Myasthenia gravis (MG) the next 4 are for Alzheimer's disease
Ganglionic Blockers - CORRECT ANSWER Mecamylamine
Hexamethonium
Trimethaphan
Inhibits the enzymatic breakdown of (neuro) transmitter - CORRECT ANSWER MAO-
inhibitor effect
MAO-Inhibitor - CORRECT ANSWER Phenelzine (many side effects)
Ganglionic Blocker effects - CORRECT ANSWER Will induce the system opposite of
tone so if PNS or an organ is dominant at tone a ganglionic blocker will induce SNS
like control
Endogenous Adrenergic Agonists effect - CORRECT ANSWER Induce SNS like
control (opposite of SLUD-BBAM)
Endogenous Adrenergic Agonists - CORRECT ANSWER Epinephrine- activates a, B1
and B2 Norepinephrine- activates a1>a1>B1 can't effect B2
Dopamine- activates D1 but at higher doses acts at B1 then alphas
Direct-Acting Alpha Agonists effects - CORRECT ANSWER Effects will mimic SNS
control on different systems based on the type of receptor the drug works on
Direct-Acting Alpha Agonists - CORRECT ANSWER Phenylephrine- a1
,NBME Cbse EXAM WITH FREQUENTLY TESTED
QUESTIONS AND RATIONALE
ALREADY GRADED A+ For GUARANTEED PASS
LATEST UPDATE 2025.
(vasoconstriction) used as an antihypotension, decongestant and a hydriatic
Clonidine- a2 (DECREASES SNS outflow from CNS and decreases NE release) used to
treat hypertension***
Direct-Acting Beta Agonists effects - CORRECT ANSWER Effects will mimic SNS control on
different systems based on the type of receptor the drug works on
, NBME Cbse EXAM WITH FREQUENTLY TESTED
QUESTIONS AND RATIONALE
ALREADY GRADED A+ For GUARANTEED PASS
LATEST UPDATE 2025.
Direct-Acting Beta Agonists - CORRECT ANSWER Dobutamine- B1 agonists
treats heart failure
Isoproterenol- nonselective B agonists
Albuterol, metaproterenol- B2 agonists creates bronchodilation
Mixed Direct and indirect sympathomimetics effects - CORRECT ANSWER Effects will
mimic SNS control
Mixed Direct and indirect sympathomimetics - CORRECT ANSWER Amphetamine-
used for ADHD, narcolepsy, (obesity)
Ephedrine
Pseudoephedrine- selective for alpha used for nasal decongestion
Indirect acting sympathomimetic - CORRECT ANSWER cocaine- stimulates NE
release and blocks NE and epinephrine reuptake
Nonselective Alpha Antagonists - CORRECT ANSWER Phenoxybenzamine-
irreversible inhibitor used to treat a tumor cell before it can be removed
Phentolamine- past use for hypertensive crisis
Alpha 1 Antagonists effect - CORRECT ANSWER blocks vasoconstriction used for
hypertension and BPH
Alpha 1 Antagonists - CORRECT ANSWER Prazosin-
hypertension Terazosin- Hypertension and BPH
Tamsulosin- BPH
Beta 1 Antagonists effect - CORRECT ANSWER cardioselective treats hypertension
and other heart related issues
Beta 1 Antagonists - CORRECT ANSWER Acebutolol
Atenolol
Betaxolol
Esmolol
Metoprolol
Non selective B antagnonists - CORRECT ANSWER Nadolol
Pindolol
Propranolol
Timolol
QUESTIONS AND RATIONALE
ALREADY GRADED A+ For GUARANTEED PASS
LATEST UPDATE 2025.
Benztropine (Cogentin) - CORRECT ANSWER An antimuscarinic used to treat
Parkinson's disease "park my benz"
Acetylcholinesterase inhibitor (AChE inhibitors) effects - CORRECT ANSWER it is an indirect
muscarinic agonist so it will produce PNS like control (SLUD-BBAM)
Malathion - CORRECT ANSWER an organophosphate insecticide that acts as an
acetylcholinesterase inhibitor
Sarin - CORRECT ANSWER an organophosphate nerve gas that acts as an
acetylcholinesterase inhibitor
Antimuscarninics (muscarinic antagonists) - CORRECT ANSWER Atropine
Glycopyrrolate
Tropicamide
Ipratropium
Darifenacin
Scopolamine
Benztropine
Atropine - CORRECT ANSWER An antimuscarinic used to treat organohosphate
poisoning bradycardia, preop/surgery to dry secretions (can produce CYCLOPLEGIA)
produces opposite of SLUD-BBAM
Pralidoxime - CORRECT ANSWER used to treat organophosphate poisoning
Glycopyrrolate - CORRECT ANSWER An antimuscarinic used for preop/surgery to
dry secretions
Tropicamide - CORRECT ANSWER An antimuscarinic used for eye exams (causes
mydriatic eyes)
Ipratropium (Atrovent) - CORRECT ANSWER An antimuscarinic used to treat asthma
"I pray I can breathe soon"
Darifenacin (Enablex) - CORRECT ANSWER An antimuscarinic used to treat
overactive bladder
Scopolamine - CORRECT ANSWER An antimuscarinic used to treat motion sickness
,NBME Cbse EXAM WITH FREQUENTLY TESTED
QUESTIONS AND RATIONALE
ALREADY GRADED A+ For GUARANTEED PASS
LATEST UPDATE 2025.
Acetylcholinesterase Restorative - CORRECT ANSWER Pralidoxime- which is used to
treat organophosphate poisoning especially nerve gasses
Acetylcholinesterase Restorative effect - CORRECT ANSWER treats
acetylcholinesterase inhibition so it restores SNS like control (opposite of SLUD-
BBAM)
Acetylcholinesterase inhibitors (AChE inhibitors) - CORRECT ANSWER
Pyridostigmine Neostigmine
Edrophonium
Donepezil
Rivastigmine
Tacrine
(Malathion)
(Sarin)
First 3 are for Myasthenia gravis (MG) the next 4 are for Alzheimer's disease
Ganglionic Blockers - CORRECT ANSWER Mecamylamine
Hexamethonium
Trimethaphan
Inhibits the enzymatic breakdown of (neuro) transmitter - CORRECT ANSWER MAO-
inhibitor effect
MAO-Inhibitor - CORRECT ANSWER Phenelzine (many side effects)
Ganglionic Blocker effects - CORRECT ANSWER Will induce the system opposite of
tone so if PNS or an organ is dominant at tone a ganglionic blocker will induce SNS
like control
Endogenous Adrenergic Agonists effect - CORRECT ANSWER Induce SNS like
control (opposite of SLUD-BBAM)
Endogenous Adrenergic Agonists - CORRECT ANSWER Epinephrine- activates a, B1
and B2 Norepinephrine- activates a1>a1>B1 can't effect B2
Dopamine- activates D1 but at higher doses acts at B1 then alphas
Direct-Acting Alpha Agonists effects - CORRECT ANSWER Effects will mimic SNS
control on different systems based on the type of receptor the drug works on
Direct-Acting Alpha Agonists - CORRECT ANSWER Phenylephrine- a1
,NBME Cbse EXAM WITH FREQUENTLY TESTED
QUESTIONS AND RATIONALE
ALREADY GRADED A+ For GUARANTEED PASS
LATEST UPDATE 2025.
(vasoconstriction) used as an antihypotension, decongestant and a hydriatic
Clonidine- a2 (DECREASES SNS outflow from CNS and decreases NE release) used to
treat hypertension***
Direct-Acting Beta Agonists effects - CORRECT ANSWER Effects will mimic SNS control on
different systems based on the type of receptor the drug works on
, NBME Cbse EXAM WITH FREQUENTLY TESTED
QUESTIONS AND RATIONALE
ALREADY GRADED A+ For GUARANTEED PASS
LATEST UPDATE 2025.
Direct-Acting Beta Agonists - CORRECT ANSWER Dobutamine- B1 agonists
treats heart failure
Isoproterenol- nonselective B agonists
Albuterol, metaproterenol- B2 agonists creates bronchodilation
Mixed Direct and indirect sympathomimetics effects - CORRECT ANSWER Effects will
mimic SNS control
Mixed Direct and indirect sympathomimetics - CORRECT ANSWER Amphetamine-
used for ADHD, narcolepsy, (obesity)
Ephedrine
Pseudoephedrine- selective for alpha used for nasal decongestion
Indirect acting sympathomimetic - CORRECT ANSWER cocaine- stimulates NE
release and blocks NE and epinephrine reuptake
Nonselective Alpha Antagonists - CORRECT ANSWER Phenoxybenzamine-
irreversible inhibitor used to treat a tumor cell before it can be removed
Phentolamine- past use for hypertensive crisis
Alpha 1 Antagonists effect - CORRECT ANSWER blocks vasoconstriction used for
hypertension and BPH
Alpha 1 Antagonists - CORRECT ANSWER Prazosin-
hypertension Terazosin- Hypertension and BPH
Tamsulosin- BPH
Beta 1 Antagonists effect - CORRECT ANSWER cardioselective treats hypertension
and other heart related issues
Beta 1 Antagonists - CORRECT ANSWER Acebutolol
Atenolol
Betaxolol
Esmolol
Metoprolol
Non selective B antagnonists - CORRECT ANSWER Nadolol
Pindolol
Propranolol
Timolol
