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USMLE STEP 3 AND ABIM INTERNAL MEDICINE BOARDS
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EXAM LATEST VERSION 2023-2024 ACTUAL EXAM 500
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QUESTIONS AND CORRECT DETAILED ANSWERS WITH
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RATIONALES
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ascites that is:
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New, Painful, or Feverish - ANSWER--tap it
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initial hypercalcemia workup - ANSWER--CMP
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Chest x-ray urinary calcium
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PTH immunoassay
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hyperventilation definition - ANSWER-->22
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daily medication for esophageal varices
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(NOT ACUTELY) - ANSWER--propanolol
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SAAG - ANSWER--Serum : Ascites Albumin Gradient
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increased PT + bleeding - ANSWER--give FFP
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hepatic encephalopathy treatment - ANSWER--Lactulose
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(A lactose look-alike that when metabolized by gut flora acidifies the inside of the
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bowel. Thus, ammonia (NH3) is converted to ammonium (NH4+). Both lactulose
and the ammonium ion cannot be absorbed and are therefore excreted.)
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Neomycin is 2nd line
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How do you quickly replace low albumin? - ANSWER--give FFP
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SAAG >1.1 - ANSWER--Portal HTN (transudate)
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SAAG <1.1 - ANSWER--Cancer and Infxn (exudate)
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Portal System:
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1. splenic vein hypertension sh
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superior mesenteric vein - ANSWER--1. esophageal & gastric varices
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2. hemmorhoids
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percent mortality of variceal bleeds - ANSWER--50%
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causes of cirrhosis - ANSWER--Alcohol
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PBC
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PSC
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Wilsons
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Hemochromatosis
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Autoimmune
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Nonalcoholic Steatohepatitis (caused by obesity, diabetes, and hyperlipidemia)
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single BEST liver test - ANSWER--PT
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(the day you die of liver disease your transaminases can be normal)
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AST elevation - ANSWER--ETOH and drugs
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ALT elevation - ANSWER--viral infection sh
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portal hypertension causes... - ANSWER--SPLENOMEGALY which then
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yields...sequestration of platelets (thrombocytopenia)
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ALK PHOS & GGTP elevation - ANSWER--biliary obstruction
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Liver Failure - ANSWER--Hypercholesterolemia (lipid mismanagement) =
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Acanthosis (lipids on RBC's) and increased MCV
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PBC (primary biliary cirrhosis) looks like: - ANSWER--An itchy, middle-aged female
with xanthelasmas and other autoimmunities.
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best: elevated Alk Phos (normal bilirubin)
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accurate: AMA (antimitochondrial antibody) & Liver Biopsy
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alpha 1 antitrypsin deficiency - ANSWER--COPD & hepatic failure
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PSC (primary sclerosing cholangitis) looks like: - ANSWER--An itchy patient with
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inflammatory bowel disease.
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best: elevated Alk Phos & Bilirubin
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accurate: ASMA (antismooth muscle antibody), ANCA, ERCP (beaded biliary
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system)
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PBC, PSC, alpha 1 antitrypsin deficiency - ANSWER--give ursodeoxycholic acid
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Wilsons Disease looks like... - ANSWER--liver disease with choreiform movement.
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best: slit lamp exam (Kayser Fleisher Rings)
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