GUIDE 2025/2026 COMPLETE QUESTIONS
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1. DNA sequences in many human genes are very similar to the sequences of
corresponding genes in chimpanzees. The most likely explanation for this
result is that - ANSWER ✓ Humans and chimpanzees share a relatively
recent common ancestor
2. It has been observed that organisms on islands are different from, but closely
related to, similar forms found on the nearest continent. This is taken as
evidence that - ANSWER ✓ Island forms and mainland forms descended
from common ancestors
3. Of the following anatomical structures, which is homologous to the wing of
a bird? - ANSWER ✓ Flipper of a cetacean
4. In Darwin's thinking, the more closely related two different organisms are,
the - ANSWER ✓ More recently they share a common ancestor
5. Charles Darwin was the first person to propose - ANSWER ✓ A mechanism
for evolution that was supported by evidence
6. Which naturalist synthesized a concept of natural selection independently of
Darwin? - ANSWER ✓ Alfred Wallace
7. What is the name given to viruses that are single-stranded RNA that acts as a
template for DNA synthesis? - ANSWER ✓ Retroviruses
,8. Why do RNA viruses appear to have higher rates of mutation? - ANSWER
✓ Replication of their genomes does not involve the proofreading steps of
DNA replication
9. Which of the following statements describes the lysogenic cycle of lambda
phage? - ANSWER ✓ The phage DNA is incorporated by crossing over into
any nonspecific site on the host cell's DNA
10.Which of the following terms describes bacteriophage DNA that has become
integrated into the host cell chromosome? - ANSWER ✓ Prophages
11.Which of the following is characteristic of the lytic cycle? - ANSWER ✓ A
large number of phages is released at a time
12.Which of the following accounts for someone who has had a herpesvirus-
mediated cold sore or genital sore getting flare-ups for the rest of life? -
ANSWER ✓ Copies of the herpesvirus genome permanently maintained in
host nuclei
13.Which of the following molecules make up the viral envelope? - ANSWER
✓ Glycoproteins
14.Why are viruses referred to as obligate parasites? - ANSWER ✓ They
cannot reproduce outside of a host cell
15.The host range of a virus is determined by - ANSWER ✓ The proteins on its
surface and that of the host
16.Which of the following DNA mutations is the most likely to be damaging to
the protein it specifies? - ANSWER ✓ A base-pair deletion
17.A frameshift mutation could result from - ANSWER ✓ Either an insertion or
deletion of a base
18.Sickle-cell disease is probably the result of which kind of mutation? -
ANSWER ✓ Point
,19.What is the most abundant type of RNA? - ANSWER ✓ rRNA
20.In the structural organization of many eukaryotic genes, individual exons
may be related to which of the following? - ANSWER ✓ The various
domains of the polypeptide product
21.Alternative RNA splicing - ANSWER ✓ Can allow the production of
proteins of different sizes from a single mRNA
22.During splicing, which molecular component of the spliceosome catalyzes
the excision reaction? - ANSWER ✓ RNA
23.What are the coding segments of a stretch of eukaryotic DNA called? -
ANSWER ✓ Exons
24.What is a ribozyme? - ANSWER ✓ An RNA with enzymatic activity
25.Which of the following helps to stabilize mRNA by inhibiting its
degradation? - ANSWER ✓ 5' cap and poly (A) tail
26.Transcription in eukaryotes requires which of the following in addition to
RNA polymerase? - ANSWER ✓ Several transcription factors (TFs)
27.In eukaryotes there are several different types of RNA polymerase. Which
type is involved in transcription of mRNA for a globin protein? - ANSWER
✓ RNA polymerase II
28.The "universal" genetic code is now known to have exceptions. Evidence for
this could be found if which of the following is true? - ANSWER ✓ If UGA,
usually a stop codon, is found to code for an amino acid such as tryptophan
(usually coded for by UGG only).
29.The nitrogenous base adenine is found in all members of which group? -
ANSWER ✓ ATP, RNA, and DNA
30.Garrod hypothesized that "inborn errors of metabolism" such as alkaptonuria
occur because - ANSWER ✓ genes dictate the production of specific
, enzymes, and affected individuals have genetic defects that cause them to
lack certain enzymes.
31.Why do histones bind tightly to DNA? - ANSWER ✓ Histones are
positively charged and DNA is negatively charged
32.Which of the following help to hold the DNA strands apart while they are
being replicated? - ANSWER ✓ Single-strand binding proteins
33.What is the role of DNA ligase in the elongation of the lagging strand during
DNA replication? - ANSWER ✓ Unwind the parental double helix
34.The leading and the lagging strands differ in that - ANSWER ✓ the leading
strand is synthesized in the same direction as the movement of the
replication fork, and the lagging strand is synthesized in the opposite
direction.
35.The difference between ATP and the nucleoside triphosphates used during
DNA synthesis is that - ANSWER ✓ The nucleoside triphosphates have the
sugar deoxyribose; ATP has the sugar ribose
36.Which of the following synthesizes short segments of RNA? - ANSWER ✓
Primase
37.Which of the following covalently connects segments of DNA? - ANSWER
✓ Ligase
38.What is the function of DNA polymerase III? - ANSWER ✓ To add
nucleotides to the end of a growing strand
39.Replication in prokaryotes differs from replication is eukaryotes for which
of these reasons? - ANSWER ✓ Prokaryotic chromosomes have a single
origin of replication, whereas eukaryotic chromosomes have many.
40.Pituitary gland - ANSWER ✓ The endocrine system's most influential gland.
Under the influence of the hypothalamus, the pituitary regulates growth and
controls other endocrine glands.