GMS6504 exam 2 questions with correct answers.

GMS6504
exam
/ /




2 questions with correct answers
/ / / /




In
/terms


/of


/Lipinski's


/rules,


/which


/of


/the


/following


/functional


/groups /serves /as /a /hydrogen /bond /donor? /- /correct /answer(s) /✔✔ /-


NH2



Will /
a
/hydrophobic


/molecule /have /a /high /or /low /logP? /- /correct /answer(s) /✔✔ /high




Which
/is


/the


/best


/explanation


/as


/to


/why


/CNS


/drugs


/tend

, /to
/have


/smaller


/polar /surface /areas /than /drugs /that /target /things /outside /of /the /CNS?


/- /correct /answer(s) /✔✔ /It /helps /the /drug /cross /the /blood /brain /barrier




Which /functional /group /is /most /often /utilized /when /making /pro-
drugs? /- /correct /answer(s) /✔✔ /Esters



Which
/of


/the


/following


/protein


/domains


/would


/you


/expect


/to


/find


/in /an /"easily /druggable" /target /but /NOT /in /an /"undruggable" /target? /-


/correct /answer(s) /✔✔ /ATP-binding /domain




Would /using /a /drug /against /cells /in /which /it /causes /synthetic /lethality
/tend


/to


/increase


/or /decrease /its /therapeutic /index? /- /correct /answer(s) /✔✔ /Increase




Inhibition
/of


/which


/enzyme


/is


/expected


/to