, Basic Updated
Immunology
Functions and Disorders
of the Immune System
Abul K. Abbas, MBBS
Professor and Chair
Department of Pathology
University of California San Francisco, School of Medicine
San Francisco, California
Andrew H. Lichtman, MD, PhD
Professor of Pathology
Harvard Medical School
Brigham and Women’s Hospital
Boston, Massachusetts
Illustrated by David L. Baker, MA, and Alexandra Baker, MS, CMI
,1600 John F. Kennedy Blvd. Ste 1800
Philadelphia, PA 19103-2899
BASIC IMMUNOLOGY: FUNCTIONS AND DISORDERS ISBN: 978-1-4160-5569-3
OF THE IMMUNE SYSTEM
Copyright © 2011 by Saunders, an imprint of Elsevier Inc.
All rights reserved. No part of this publication may be reproduced or transmitted in any form or by any
means, electronic or mechanical, including photocopying, recording, or any information storage and retrieval
system, without permission in writing from the publisher. Permissions may be sought directly from Elsevier’s
Rights Department: phone: (+1) 215 239 3804 (US) or (+44) 1865 843830 (UK); fax: (+44) 1865 853333;
e-mail: . You may also complete your request on-line via the Elsevier website
at http://www.elsevier.com/permissions.
Notice
Knowledge and best practice in this field are constantly changing. As new research and experience
broaden our knowledge, changes in practice, treatment, and drug therapy may become necessary or
appropriate. Readers are advised to check the most current information provided (i) on procedures
featured or (ii) by the manufacturer of each product to be administered, to verify the recommended dose
or formula, the method and duration of administration, and contraindications. It is the responsibility of
the practitioner, relying on his or her own experience and knowledge of the patient, to make diagnoses, to
determine dosages and the best treatment for each individual patient, and to take all appropriate safety
precautions. To the fullest extent of the law, neither the Publisher nor the Editors assumes any liability for
any injury and/or damage to persons or property arising out of or related to any use of the material
contained in this book.
The Publisher
Previous editions copyrighted 2009, 2006, 2004, 2001
Library of Congress Cataloging-in-Publication Data
Abbas, Abul K.
Basic immunology: functions and disorders of the immune system / Abul
K. Abbas, Andrew H. Lichtman. – 3rd ed.
p. ; cm.
Includes bibliographical references and index.
ISBN 978-1-4160-5569-3
1. Immunology. 2. Immunity. I. Lichtman, Andrew H. II. Title.
[DNLM: 1. Immunity. 2. Hypersensitivity. 3. Immune System–physiology. 4. Immunologic Deficiency
Syndromes. QW 504 A122b 2009]
QR181.A28 2009
616.07’9–dc22
2007030085
Acquisitions Editor: William Schmitt
Developmental Editor: Rebecca Gruliow
Editorial Assistant: Laura Stingelin
Design Direction: Gene Harris Working together to grow
libraries in developing countries
www.elsevier.com | www.bookaid.org | www.sabre.org
Printed in China.
Last digit is the print number: 9 8 7 6 5 4 3 2
, To Ann, Jonathan, Rehana,
Sheila, Eben, Ariella, Amos, Ezra
Immunology
Functions and Disorders
of the Immune System
Abul K. Abbas, MBBS
Professor and Chair
Department of Pathology
University of California San Francisco, School of Medicine
San Francisco, California
Andrew H. Lichtman, MD, PhD
Professor of Pathology
Harvard Medical School
Brigham and Women’s Hospital
Boston, Massachusetts
Illustrated by David L. Baker, MA, and Alexandra Baker, MS, CMI
,1600 John F. Kennedy Blvd. Ste 1800
Philadelphia, PA 19103-2899
BASIC IMMUNOLOGY: FUNCTIONS AND DISORDERS ISBN: 978-1-4160-5569-3
OF THE IMMUNE SYSTEM
Copyright © 2011 by Saunders, an imprint of Elsevier Inc.
All rights reserved. No part of this publication may be reproduced or transmitted in any form or by any
means, electronic or mechanical, including photocopying, recording, or any information storage and retrieval
system, without permission in writing from the publisher. Permissions may be sought directly from Elsevier’s
Rights Department: phone: (+1) 215 239 3804 (US) or (+44) 1865 843830 (UK); fax: (+44) 1865 853333;
e-mail: . You may also complete your request on-line via the Elsevier website
at http://www.elsevier.com/permissions.
Notice
Knowledge and best practice in this field are constantly changing. As new research and experience
broaden our knowledge, changes in practice, treatment, and drug therapy may become necessary or
appropriate. Readers are advised to check the most current information provided (i) on procedures
featured or (ii) by the manufacturer of each product to be administered, to verify the recommended dose
or formula, the method and duration of administration, and contraindications. It is the responsibility of
the practitioner, relying on his or her own experience and knowledge of the patient, to make diagnoses, to
determine dosages and the best treatment for each individual patient, and to take all appropriate safety
precautions. To the fullest extent of the law, neither the Publisher nor the Editors assumes any liability for
any injury and/or damage to persons or property arising out of or related to any use of the material
contained in this book.
The Publisher
Previous editions copyrighted 2009, 2006, 2004, 2001
Library of Congress Cataloging-in-Publication Data
Abbas, Abul K.
Basic immunology: functions and disorders of the immune system / Abul
K. Abbas, Andrew H. Lichtman. – 3rd ed.
p. ; cm.
Includes bibliographical references and index.
ISBN 978-1-4160-5569-3
1. Immunology. 2. Immunity. I. Lichtman, Andrew H. II. Title.
[DNLM: 1. Immunity. 2. Hypersensitivity. 3. Immune System–physiology. 4. Immunologic Deficiency
Syndromes. QW 504 A122b 2009]
QR181.A28 2009
616.07’9–dc22
2007030085
Acquisitions Editor: William Schmitt
Developmental Editor: Rebecca Gruliow
Editorial Assistant: Laura Stingelin
Design Direction: Gene Harris Working together to grow
libraries in developing countries
www.elsevier.com | www.bookaid.org | www.sabre.org
Printed in China.
Last digit is the print number: 9 8 7 6 5 4 3 2
, To Ann, Jonathan, Rehana,
Sheila, Eben, Ariella, Amos, Ezra
