1-Which of the following molecules presents on all T cells?
a. CD1
b. CD3
c. CD20
d. CD2
2-Which of the following molecules is expressed on the surface of B cells?
a. CD4
b. CD3
c. CD19
d. CD28
3-Which of the following cells forming the largest % in WBC differential count in adult?
a. Lymphocyte
b. Mast cell
c. Macrophage
d. Neutrophil
4- Which of the following cells in antigen presenting cell?
a. Basophil
b. Mast cell
c. Macrophage
d. Neutrophil
5- Which of the following organs consider primary lymphoid organ?
a. Lymph nodes
b. Spleen
c. Tonsils
d. Thymus
6- As regard T cell maturation, which of the following organs consider primary lymphoid organ?
a. Bone marrow
b. Spleen
c. Tonsils
d. Thymus
7- Which of the following cells consider phagocytic cell?
a. Basophil
b. Mast cell
c. Neutrophil
d. NK cell
,8 - As regard B cell maturation, which of the following organs consider primary lymphoid organ ?
a. Bone marrow
b. Spleen
c. Tonsils
d. Thymus
9- As regard chemical nature of antigen, what is the most potent antigen?
a. Lipids
b. Nucleic acids
c. Proteins
d. Polysaccharides
10- Which of the following chemical component consider T- independent antigens?
a. Lipids
b. Nucleic acids
c. Proteins
d. Polysaccharides
11- A diploid cell expresses up to ….different class I and class II molecules
a. 2
b. 3
c. 6
d. 12
12- As regard T- dependent antigens, the Stimulated cell (s)………and antibody class(es) produced…….
a. Both T & B cells- IgM only
b. Both T & B cells- All antibody classes
c. B cells only - All antibody classes
d. B cells only - IgM only
13- As regard Superantigens, they are …….and activate T cell with production ……….
a. Processed - monoclonal activation
b. Processed - polyclonal activation
c. Not processed - polyclonal activation
d. Not processed - monoclonal activation
14- Which of the following cells have the ability of killing by production of granzymes?
a. Neutrophils
b. Macrophages
c. Natural killer
d. Mast cells
,15- What is the first step in phagocytosis?
a. Engulfment
b. Killing
c. Attachment
d. Chemotaxis
16- In Chronic granulomatous disease (CGD), there is defect in NADPH oxidase inside macrophage
lead to defect in……..
a. Killing mechanism
b. Opsonization
c. Antigen presentation
d. Cytokine production
17- What is the responsible about production of Pro-inflammatory cytokines: IL-1, IL-6 and TNF-α?
a. Neutrophils
b. Macrophages
c. Natural killer
d. Mast cells
18- One of the most Therapeutic Use of Interferons (IFNs) is elimination of:
a. Bacteria
b. Fungus
c. Virus
d. Protozoa
19- Pattern recognition molecules
a. Are generated by complex recombination of multiple gene segments
b. Can distinguish self from pathogen
c. Can tell the difference between discrete genetic variants of a pathogen
d. First appear in evolution in mammals
20- Which of the following are phagocytic cells derived from monocytes
a. Neutrophils
b. Mast cells
c. NK cells
d. Macrophages
21- NK cells recognize and kill
a. Normal host cells
b. Cells with increased expression of MHC-I molecules
c. Cells with decreased expression of MHC-I molecules
d. Intracellular pathogens
, 22- A polymorphonuclear neutrophil (PMN):
A. Is a bone marrow stem cell.
B. Is closely similar to a mast cell.
C. Contains microbicidal cytoplasmic granules .
D. Is not a professional phagocytic cell.
23- Lysozyme :
A. Is a cytoplasmic organelle.
B. Activates complement .
C. Is a proteolytic enzyme.
D. Splits peptidoglycan.
E. Is released by mast cells .
24- Interferons :
A. Are found only in mammalian species.
B. Are divided into 5 main families .
C. Induce enzyme synthesis in the target cell.
D. Only affect infected cells.
E. Are specific for individual viruses.
25- Polymorphonuclear neutrophils attack bacteria :
A. Exclusively by oxygen-dependent mechanisms.
B. Exclusively by oxygen-independent mechanisms .
C. By phagocytosis.
D. By secreting complement.
26- Acute inflammation can be initiated by:
A. Mast cell activation.
B. Influx of neutrophils .
C. An increase in vascular permeability .
D. C3 .
E. Lysozyme.
27- T cells (T lymphocytes) are crucial in the recognition of antigens presented by self-MHC. The T cell
progenitors undergo proliferation and differentiation in the thymus and form a mature T cell. Which
of the following organ is the origin of T cell progenitors?
a. Thymus
b. Hepatocytes
c. Bone marrow
d. Lymph node
a. CD1
b. CD3
c. CD20
d. CD2
2-Which of the following molecules is expressed on the surface of B cells?
a. CD4
b. CD3
c. CD19
d. CD28
3-Which of the following cells forming the largest % in WBC differential count in adult?
a. Lymphocyte
b. Mast cell
c. Macrophage
d. Neutrophil
4- Which of the following cells in antigen presenting cell?
a. Basophil
b. Mast cell
c. Macrophage
d. Neutrophil
5- Which of the following organs consider primary lymphoid organ?
a. Lymph nodes
b. Spleen
c. Tonsils
d. Thymus
6- As regard T cell maturation, which of the following organs consider primary lymphoid organ?
a. Bone marrow
b. Spleen
c. Tonsils
d. Thymus
7- Which of the following cells consider phagocytic cell?
a. Basophil
b. Mast cell
c. Neutrophil
d. NK cell
,8 - As regard B cell maturation, which of the following organs consider primary lymphoid organ ?
a. Bone marrow
b. Spleen
c. Tonsils
d. Thymus
9- As regard chemical nature of antigen, what is the most potent antigen?
a. Lipids
b. Nucleic acids
c. Proteins
d. Polysaccharides
10- Which of the following chemical component consider T- independent antigens?
a. Lipids
b. Nucleic acids
c. Proteins
d. Polysaccharides
11- A diploid cell expresses up to ….different class I and class II molecules
a. 2
b. 3
c. 6
d. 12
12- As regard T- dependent antigens, the Stimulated cell (s)………and antibody class(es) produced…….
a. Both T & B cells- IgM only
b. Both T & B cells- All antibody classes
c. B cells only - All antibody classes
d. B cells only - IgM only
13- As regard Superantigens, they are …….and activate T cell with production ……….
a. Processed - monoclonal activation
b. Processed - polyclonal activation
c. Not processed - polyclonal activation
d. Not processed - monoclonal activation
14- Which of the following cells have the ability of killing by production of granzymes?
a. Neutrophils
b. Macrophages
c. Natural killer
d. Mast cells
,15- What is the first step in phagocytosis?
a. Engulfment
b. Killing
c. Attachment
d. Chemotaxis
16- In Chronic granulomatous disease (CGD), there is defect in NADPH oxidase inside macrophage
lead to defect in……..
a. Killing mechanism
b. Opsonization
c. Antigen presentation
d. Cytokine production
17- What is the responsible about production of Pro-inflammatory cytokines: IL-1, IL-6 and TNF-α?
a. Neutrophils
b. Macrophages
c. Natural killer
d. Mast cells
18- One of the most Therapeutic Use of Interferons (IFNs) is elimination of:
a. Bacteria
b. Fungus
c. Virus
d. Protozoa
19- Pattern recognition molecules
a. Are generated by complex recombination of multiple gene segments
b. Can distinguish self from pathogen
c. Can tell the difference between discrete genetic variants of a pathogen
d. First appear in evolution in mammals
20- Which of the following are phagocytic cells derived from monocytes
a. Neutrophils
b. Mast cells
c. NK cells
d. Macrophages
21- NK cells recognize and kill
a. Normal host cells
b. Cells with increased expression of MHC-I molecules
c. Cells with decreased expression of MHC-I molecules
d. Intracellular pathogens
, 22- A polymorphonuclear neutrophil (PMN):
A. Is a bone marrow stem cell.
B. Is closely similar to a mast cell.
C. Contains microbicidal cytoplasmic granules .
D. Is not a professional phagocytic cell.
23- Lysozyme :
A. Is a cytoplasmic organelle.
B. Activates complement .
C. Is a proteolytic enzyme.
D. Splits peptidoglycan.
E. Is released by mast cells .
24- Interferons :
A. Are found only in mammalian species.
B. Are divided into 5 main families .
C. Induce enzyme synthesis in the target cell.
D. Only affect infected cells.
E. Are specific for individual viruses.
25- Polymorphonuclear neutrophils attack bacteria :
A. Exclusively by oxygen-dependent mechanisms.
B. Exclusively by oxygen-independent mechanisms .
C. By phagocytosis.
D. By secreting complement.
26- Acute inflammation can be initiated by:
A. Mast cell activation.
B. Influx of neutrophils .
C. An increase in vascular permeability .
D. C3 .
E. Lysozyme.
27- T cells (T lymphocytes) are crucial in the recognition of antigens presented by self-MHC. The T cell
progenitors undergo proliferation and differentiation in the thymus and form a mature T cell. Which
of the following organ is the origin of T cell progenitors?
a. Thymus
b. Hepatocytes
c. Bone marrow
d. Lymph node
