Pharmacology MCQs
PEW June 2001
1 The following are true for adrenaline EXCEPT:
a) it acts via G-proteins
b) alpha receptor stimulation results in decreased cAMP production
c) it may be administered via inhalation, orally and parentally
d) it has no active metabolites
e) in cardiac arrest it facilitates CPR via peripheral varioconstruction
2 Heparin:
a) inhibits clotting by decreasing anti-thrombin III effects
b) oral bioavailability is 20-30%
c) is low plasma protein bound
d) molecular weight ranges from 3,000 – 60,000
e) binds to anti-thrombin III causing a conformational change
3 Volume of distribution:
a) is always a real volume
b) amount of drug in plasma
concentration in body
c) concentration of drug in plasma
amount of drug in blood
d) amount of drug in body
concentration of drug in plasma
e) AUC
dose
4 Aspirin:
a) is hydrolysed to acetone and salicylate
b) exhibits first order kinetics with elimination in low doses
c) is mostly conjugated by the liver and excreted in the bile
d) reversibly blocks the cyclooxygenase enzyme
e) causes an immediate doubling of bleeding time
5 Amiodarone:
a) effects Na+, K+ channels but not Ca2+ channels
b) has antianginal effects
c) has a short half life
d) increases peripheral resistance
e) has little effect on the lung
C:\Users\lauraj\Desktop\Triage Monkeys\Part I past questions by topic\Pharmacology MCQs\pharm_random7_mcqs.doc
, 6 Tricyclic antidepressants:
a) have a low volume of distribution
b) are useful in urinary retention and chronic pain
c) can prolong QT interval
d) block the enzyme which degrades amine neurotransmitters
e) is useful in severe depression with strong suicidal ideation
7 Regarding diazepam:
a) it has no active metabolites
b) activated charcoal is useful in overdose
c) it undergoes extensive enterohepatic recirculation
d) it is a GABA antagonist via the benzodiazepine receptors
e) It has no spinal inhibitory action
8 Atropine:
a) can cause bronchodilation
b) produces miosis
c) is not lipid-soluble
d) blocks reuptake of ACH
e) causes an increase in salivary gland secretions
9 All are true about penicillins EXCEPT:
a) most penicillins only cross blood-brain barrier when the meninges are
inflamed
b) penicillins don’t require adjustment in renal failure
c) penicillins inhibit cross linkage of peptidoglycans in cell wall
d) piperacillin is a penicillin active against pseudomonas
e) only about 5-10% of people with a past history of penicillin allergy have a
reaction on re-exposure
10 Which of the following receptor-ligand pathway is TRUE:
a) insulin and G-protein receptor
b) mineralocorticoid and tyrosine kinase receptor
c) vitamin D and intracellular receptor
d) adrenaline and ligand gated channel receptor
e) platelet derived growth factor and cytokine receptor
C:\Users\lauraj\Desktop\Triage Monkeys\Part I past questions by topic\Pharmacology MCQs\pharm_random7_mcqs.doc
PEW June 2001
1 The following are true for adrenaline EXCEPT:
a) it acts via G-proteins
b) alpha receptor stimulation results in decreased cAMP production
c) it may be administered via inhalation, orally and parentally
d) it has no active metabolites
e) in cardiac arrest it facilitates CPR via peripheral varioconstruction
2 Heparin:
a) inhibits clotting by decreasing anti-thrombin III effects
b) oral bioavailability is 20-30%
c) is low plasma protein bound
d) molecular weight ranges from 3,000 – 60,000
e) binds to anti-thrombin III causing a conformational change
3 Volume of distribution:
a) is always a real volume
b) amount of drug in plasma
concentration in body
c) concentration of drug in plasma
amount of drug in blood
d) amount of drug in body
concentration of drug in plasma
e) AUC
dose
4 Aspirin:
a) is hydrolysed to acetone and salicylate
b) exhibits first order kinetics with elimination in low doses
c) is mostly conjugated by the liver and excreted in the bile
d) reversibly blocks the cyclooxygenase enzyme
e) causes an immediate doubling of bleeding time
5 Amiodarone:
a) effects Na+, K+ channels but not Ca2+ channels
b) has antianginal effects
c) has a short half life
d) increases peripheral resistance
e) has little effect on the lung
C:\Users\lauraj\Desktop\Triage Monkeys\Part I past questions by topic\Pharmacology MCQs\pharm_random7_mcqs.doc
, 6 Tricyclic antidepressants:
a) have a low volume of distribution
b) are useful in urinary retention and chronic pain
c) can prolong QT interval
d) block the enzyme which degrades amine neurotransmitters
e) is useful in severe depression with strong suicidal ideation
7 Regarding diazepam:
a) it has no active metabolites
b) activated charcoal is useful in overdose
c) it undergoes extensive enterohepatic recirculation
d) it is a GABA antagonist via the benzodiazepine receptors
e) It has no spinal inhibitory action
8 Atropine:
a) can cause bronchodilation
b) produces miosis
c) is not lipid-soluble
d) blocks reuptake of ACH
e) causes an increase in salivary gland secretions
9 All are true about penicillins EXCEPT:
a) most penicillins only cross blood-brain barrier when the meninges are
inflamed
b) penicillins don’t require adjustment in renal failure
c) penicillins inhibit cross linkage of peptidoglycans in cell wall
d) piperacillin is a penicillin active against pseudomonas
e) only about 5-10% of people with a past history of penicillin allergy have a
reaction on re-exposure
10 Which of the following receptor-ligand pathway is TRUE:
a) insulin and G-protein receptor
b) mineralocorticoid and tyrosine kinase receptor
c) vitamin D and intracellular receptor
d) adrenaline and ligand gated channel receptor
e) platelet derived growth factor and cytokine receptor
C:\Users\lauraj\Desktop\Triage Monkeys\Part I past questions by topic\Pharmacology MCQs\pharm_random7_mcqs.doc
