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Artemisinin_Combination_Therapy_PPT

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Artemisinin-Based
Combination
Therapy (ACT)
TARUN JAYSWAL
ROLL NO. - 134

,INTRODUCTION TO ACT


 ACT = Artemisinin derivative + long half-life
partner drug
 Used for uncomplicated falciparum malaria
 WHO recommends ACT to prevent resistance
 Rapid parasite clearance & reduced
transmission

, Why ACT?


 Short t½ drugs (artemisinins): Rapid action,
but risk of recurrence
 Long t½ drugs (partner): Sustained action to
prevent recrudescence
 Avoids resistance by dual mechanisms
 Treats all asexual stages

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