Artemisinin-Based
Combination
Therapy (ACT)
TARUN JAYSWAL
ROLL NO. - 134
,INTRODUCTION TO ACT
ACT = Artemisinin derivative + long half-life
partner drug
Used for uncomplicated falciparum malaria
WHO recommends ACT to prevent resistance
Rapid parasite clearance & reduced
transmission
, Why ACT?
Short t½ drugs (artemisinins): Rapid action,
but risk of recurrence
Long t½ drugs (partner): Sustained action to
prevent recrudescence
Avoids resistance by dual mechanisms
Treats all asexual stages
Combination
Therapy (ACT)
TARUN JAYSWAL
ROLL NO. - 134
,INTRODUCTION TO ACT
ACT = Artemisinin derivative + long half-life
partner drug
Used for uncomplicated falciparum malaria
WHO recommends ACT to prevent resistance
Rapid parasite clearance & reduced
transmission
, Why ACT?
Short t½ drugs (artemisinins): Rapid action,
but risk of recurrence
Long t½ drugs (partner): Sustained action to
prevent recrudescence
Avoids resistance by dual mechanisms
Treats all asexual stages