Anatomy, Pharmacology & Radiology – Verified Study Guide 2025 |
EXAM QUESTIONS AND ANSWERS AT THE END OF EACH
TOPIC
Johns Hopkins University School of Medicine
Definition of wounds and classification
The healing process
Keloids: predictive factors, clinical presentation, pathology, and treatment
Functional or aesthetic alterations of scar
Pathological scar
Correction of retractive scars
Two methods:
1) Z-plasty: create two triangular flaps, incision along the scar, changes orientation of the scar (perpendicular to
previous). We can choose the angle of the flaps, the greater the angle, the lengthier the scar. It recruits adjacent
tissue to the scar reducing skin tension.
2) Autologous fat grafting: take fat (generally thigh or abdomen) from the patient and inject it into another
region of the body. Restores volume.
Definition of grafts and flaps
• Graft = healthy tissue (ex. skin, cartilage, bone) harvested from one body area (donor site)
and transplanted to another (recipient bed), without its own blood supply.
• Flap = maintains its own blood supply and is therefore transferred with a pedicle (portion of the tissue
that ensures its nourishment as it is composed of an artery, vein, and sometimes also nerves)
History of grafts
1500 BC India = skin graft use for traumatic nasal amputation
1804 (Baronio) = skin graft in a lamb
1840 (Warren and Pancoast) = described first autologous skin graft in humans
Ollier (1872) and Thiersch (1886) = human split-thickness skin graft (STSG)
Wolfe (1893) introduced the concept of human full-thickness skin graft (FTSG) which was further detailed
by Krause (1893).
History of flaps
Classification of grafts
,C: composition = single (one tissue) and composite (at least 2 layers)
U: use = autotopic (same
O: origin =
T: thickness
Classification of flaps
Graft’s take process
Differences between a graft and a flap
Indication for grafts
Indication for flaps
Vascular supply of flaps
The Z pasty
The V Y plasty
The Limburg flap
Definition of burn disease
Definition of burn shock
Parkland formula and Curreri formula
Multiorgan complciatios in burn disease
Surgical treatment in burn disease
Defintion of excisional and incisional biopsy
Guidelines for surgical treatment of melanoma
Definition of sentinel lymph node biopsy
Definition of radical node dissection
Surgical strategies for thin melanoma
Surgical strategy for thick melanoma
Autologous breast reconstruction
Heterologous breats reconstruction
Immediate breast reconstruction
Delayed breast reconstruction
Classification of breast implants
Two-step breast reconstruction
Flaps for breast reconstruction
,Breast reconstruction with grafts
Definition of malformation
Head and neck malformations
Difference between cleft lip and cleft palate
Timetable of surgical correction for cleft lip and palate
Definition and classification of craniosynostosis
Signs and symptoms of craniosynostosis
Upper limb malformation
Definition of syndactyly
Chest malformations
Definition of poland syndrome
Definition of tuberous breast deformity
Difference between hypospadia and epispadias
Langer’s line definition
Classification of sutures
Classification of burns
Differential diagnosis: venous and arterial ulcers
Pathophysiology of bedsores
Psychiatry/Behavioral Science
A case where a 4-year-old boy presents with a spiral fracture, multiple bruises of different healing stages,
and cigarette burns, indicating possible child abuse.
Child Abuse & Neglect
An incident involving an 82-year-old woman showing signs of fear, undernourishment, bruising, and
dependency on her son, signaling potential elder abuse.
Elder Abuse
A condition where a 30-year-old woman experiences chronic fatigue, concentration issues, and anxiety
impacting daily life.
Generalized Anxiety Disorder (GAD)
A disorder characterized by recurrent episodes of panic attacks in a 27-year-old man, including
symptoms like chest tightness and fear of losing control.
Panic Disorder
An affliction where a 19-year-old college student has intense fear of public speaking and social
gatherings, thus affecting her academic performance.
Social Anxiety Disorder (Social Phobia)
A situation where a 38-year-old woman avoids public spaces due to fear of panic attacks, resulting in
significant functional impairment.
Agoraphobia
, A condition in which a 6-year-old girl speaks normally at home but is silent in social settings, hindering
her education.
Selective Mutism
A case involving a 10-year-old boy who shows distress and physical complaints when separated from his
parents, indicating separation anxiety.
Separation Anxiety Disorder
A scenario where a 45-year-old woman presents with persistent sadness, sleep issues, and feelings of guilt
over a month.
Major Depressive Disorder (MDD)
A long-term condition where a 32-year-old man feels 'down' for three years with low self-esteem and lack
of interest.
Persistent Depressive Disorder (Dysthymia)
A disorder in which a 28-year-old woman experiences mood swings and physical symptoms linked to
menstruation.
Premenstrual Dysphoric Disorder (PMDD)
A specific anxiety disorder where a 24-year-old woman has intense fear of spiders, impacting her daily
life.
Specific Phobia
A case involving a 23-year-old man showing social withdrawal and bizarre beliefs, indicative of
schizophrenia.
Schizophrenia
A short-term condition where a 22-year-old college student has hallucinations and disorganized behavior
lasting three months.
Schizophreniform Disorder
A disorder characterized by delusions and mood symptoms in a 30-year-old woman.
Schizoaffective Disorder
A case of a 46-year-old man with a well-functioning demeanor but holds a firm belief of being poisoned.
Delusional Disorder
A sudden onset of psychotic symptoms lasting five days in a 19-year-old woman following a breakup.
Brief Psychotic Disorder
A situation where a 26-year-old man battles intrusive thoughts about contamination and compulsive
hand washing.
Obsessive-Compulsive Disorder (OCD)
A psychological state observed in a 35-year-old man with elevated mood, sleep disruption, and impulsive
behavior.
Bipolar I Disorder
A condition involving periods of increased energy and a previous major depressive episode in a 29-year-
old woman.
Bipolar II Disorder
A case of a 47-year-old man presenting withdrawals after alcohol cessation, illustrating alcohol
dependence.
Alcohol Use Disorder
A scenario involving a 65-year-old woman experiencing cravings and withdrawal symptoms after
quitting smoking.
Tobacco Use Disorder
An incident with a 21-year-old man experiencing symptoms from excessive marijuana consumption.
Cannabis Use Disorder
A condition seen in a 38-year-old woman developing headaches and irritability after cutting caffeine.
Caffeine Withdrawal
A case of a 29-year-old man presenting with agitation and paranoia after cocaine use.
Stimulant Intoxication
A presentation of withdrawal symptoms in a 33-year-old man post-heroin use.