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Which genetic marker indicates that a patient may be at an increased risk of breast and/or ovarian
cancer?
BRCA1/BRCA2
Anatomical site classifications of cancer
Carcinoma-skin, glands, mucous membranes.
Sarcoma-muscle, connective tissue, bone, and fat.
Lymphoma/leukemia-Originate in blood.
Cancer Staging
Stage 0-Cancer in situ-localized cells with no threat of metastasis.
Stage 1-Limited local growth-limited to tissue of origin.
Stage 2-Limited local spread.
Stage 3-Extensive local and regional spread.
Stage 4-Metastasis.
TNM classification
T-Tumor size and invasiveness.
N-Spread to lymph nodes.
M-Metastasis.
CAUTION
C-changes in bowel/bladder habits.
A-A sore that doesn't heal.
U-Unusual bleeding or discharge.
T-Thickening or a lump in breast or elsewhere.
I-Indigestion or difficulty swallowing.
O-Obvious changes in wart or mole. N-Nagging
cough or hoarseness.
Thrombocytopenia
, Platelet count <50,000.
DELAYED TOXICITY caused by chemotherapy, may cause bleeding and hemorrhage. Pt should avoid
straining, platelet transfusion may be needed.
Caused by radiation to head and neck and chemo
Mucousitis, Stomatitis, Esophagitis
Delayed effects of chemotherapy
Occur 2 hours to months after treatment. Include: alopecia, mucousitis, neurotoxicity,
thrombocytopenia, bone marrow suppression, neutropenia, anemia, fatigue that interferes with normal
daily living, nausea, vomiting diarrhea.
Acute toxicity
Occurs during or immediately after chemo administration. Usually anaphylactic or hypersensitivity
reaction. Nausea, vomiting, and heart dysrhythmias are anticipated.
Cell cycle phase specific chemo
Attacks cells in proliferation stage to reduce spread of cancer.
Cell cycle phase non-specific
Will attack any area of cell proliferation, in any cell cycle.
Breast cancer screening guidelines
Consistent monthly self breast exams starting at age 20.
Age 45-54-annual mammograms.
Age 55 and older, mammograms every 2 years.
Clinical manifestations of lung cancer
Early signs-nagging cough, mild to severe chest pain, dyspnea.
Late signs-anorexia, vomiting, cardiac tamponade, dysrhythmias.
Non-small cell lung cancer (NSCLC)
a group of lung cancers that includes squamous cell carcinoma (slow progression), adenocarcinoma
(moderate progression), and large cell carcinoma (rapid progression).
Small cell lung cancer (SCLC)
Very rapid progression, most malignant form of lung cancer. Spreads via lymph and blood with frequent
metastasis to the brain. Radiation and chemo may be used to shrink tumor and make breathing easier.
Tamoxifen