NR565 / NR 565 Midterm Exam Study Guide (Latest 2024 /
2025): Advanced Pharmacology Fundamentals - Chamberlain
Which Drugs can APRNS perscribe - correct answer -DEA license will allow for prescribing schedules 2-5
there can be restrictions as noted in collaborative agreement. maybe facility/state dependent.
Who determines and regulates prescriptive authority? - correct answer -determines: APRNS can
prescribe without limitation and is state dependent. It is regulated by health professional board state
board of nursing or state board of medicine or pharmacy. federal government controls regulation but no
control over prescriptive authority.
How does limited prescriptive authority impact patients within the healthcare system? - correct answer
-Creates numerous barriers to quality affordable and acessible patient care.
Key responsibilities to prescribing? - correct answer -Do not prescribe to family/friends or yourself.
document a thorough history and physical examination. Include discussions with patient about risk
factors and side effects, medication monitoring or titration. if additional consults are made, know
limitations, keep rx pads in a safe place confirm allergies verify medication list dont let insurance dictate
quality of RN charting is key.
what should be used to make prescribing decisions? - correct answer -Cost, availability, current practice
guidelines, medication interactions with food side effects need for monitoring how drug is metabolized.
special populations. ask if prescriptions are cost prohibitive.
Pharmacokinetics - correct answer -what the body does to the drug
Pharmacodynamics - correct answer -what the drug does to the body
physilogic changes that can affect the pharmaconetics in older adults. - correct answer -absorption: inc
gastric PH decreased absorptive surface area and dec splanchnic blood flow. dec GI motility delayed
gastric emptying distribution: inc body fat dec lean body mass dec total body water serum albumin
cardiac output. metabolism: dec hepatic blood flow mass and activity of hepatic enzymes. excretion:
decreased renal blood flow GFR tubular secretion and number of nephrons.
, NR565 / NR 565 Midterm Exam Study Guide (Latest 2024 /
2025): Advanced Pharmacology Fundamentals - Chamberlain
reducing adverse drug reaction in older adults? - correct answer -Thorough drug history go low and slow
with initiating drug therapy monitor clinical responses and plasma levels use simple medication regimen,
monitor drug interaction review drug therapy dispose old medications promote adherence use beers
criteria.
Beers Criteria - correct answer -A list of medications that are generally considered inappropriate when
given to elderly people
impacts of polypharmacy - correct answer -using 5 or more medications daily leads to possible drug
interactions.
CYP450 inhibitors - correct answer -CRACK AMIGOS
Chloramphenicol
Ritonavir (protease inhibitor)
Amiodarone
Ciprofloxacin
Ketocanazole (and other azoles)
Acute alcohol use
Valproate
Isoniazid
Grapefruit Juice
Sulfonamides
CYP450 inhibitors function - correct answer -slow down the metabolic activity of specific enzymes,
causing a decrease in the rate/extent of metabolism of other drugs that are substrates for those same
enzymes this can cause drug toxicity.
CYP450 inducers - correct answer -barbituates, griseofulvin, carbamazepine, rifampin, st. john wart,
chronic alcoholism, phenytoin (CRAP GPS)
2025): Advanced Pharmacology Fundamentals - Chamberlain
Which Drugs can APRNS perscribe - correct answer -DEA license will allow for prescribing schedules 2-5
there can be restrictions as noted in collaborative agreement. maybe facility/state dependent.
Who determines and regulates prescriptive authority? - correct answer -determines: APRNS can
prescribe without limitation and is state dependent. It is regulated by health professional board state
board of nursing or state board of medicine or pharmacy. federal government controls regulation but no
control over prescriptive authority.
How does limited prescriptive authority impact patients within the healthcare system? - correct answer
-Creates numerous barriers to quality affordable and acessible patient care.
Key responsibilities to prescribing? - correct answer -Do not prescribe to family/friends or yourself.
document a thorough history and physical examination. Include discussions with patient about risk
factors and side effects, medication monitoring or titration. if additional consults are made, know
limitations, keep rx pads in a safe place confirm allergies verify medication list dont let insurance dictate
quality of RN charting is key.
what should be used to make prescribing decisions? - correct answer -Cost, availability, current practice
guidelines, medication interactions with food side effects need for monitoring how drug is metabolized.
special populations. ask if prescriptions are cost prohibitive.
Pharmacokinetics - correct answer -what the body does to the drug
Pharmacodynamics - correct answer -what the drug does to the body
physilogic changes that can affect the pharmaconetics in older adults. - correct answer -absorption: inc
gastric PH decreased absorptive surface area and dec splanchnic blood flow. dec GI motility delayed
gastric emptying distribution: inc body fat dec lean body mass dec total body water serum albumin
cardiac output. metabolism: dec hepatic blood flow mass and activity of hepatic enzymes. excretion:
decreased renal blood flow GFR tubular secretion and number of nephrons.
, NR565 / NR 565 Midterm Exam Study Guide (Latest 2024 /
2025): Advanced Pharmacology Fundamentals - Chamberlain
reducing adverse drug reaction in older adults? - correct answer -Thorough drug history go low and slow
with initiating drug therapy monitor clinical responses and plasma levels use simple medication regimen,
monitor drug interaction review drug therapy dispose old medications promote adherence use beers
criteria.
Beers Criteria - correct answer -A list of medications that are generally considered inappropriate when
given to elderly people
impacts of polypharmacy - correct answer -using 5 or more medications daily leads to possible drug
interactions.
CYP450 inhibitors - correct answer -CRACK AMIGOS
Chloramphenicol
Ritonavir (protease inhibitor)
Amiodarone
Ciprofloxacin
Ketocanazole (and other azoles)
Acute alcohol use
Valproate
Isoniazid
Grapefruit Juice
Sulfonamides
CYP450 inhibitors function - correct answer -slow down the metabolic activity of specific enzymes,
causing a decrease in the rate/extent of metabolism of other drugs that are substrates for those same
enzymes this can cause drug toxicity.
CYP450 inducers - correct answer -barbituates, griseofulvin, carbamazepine, rifampin, st. john wart,
chronic alcoholism, phenytoin (CRAP GPS)
