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1. The connection between 2 neurons are called . synapse
Its the site of transmission, primarily uni- information
directional. They have highly specialized structures channels
such as , and related to synap- receptors
tic synapse. machinery
2. There are 2 types of synapse, one is called electrical
chemica
synapse and the other is called synapse. l
synapse is much simpler compared electrical
to
chemica
synapse l
3. In a electrical synapse, the electrical event directly
in one cell passes to another cell. These rapidly
currents move very . In a electrical very close
synapse the cell
are to each other. Unlike chemical synapse bidirectional
their signal can be and are controlled gap junctions
by
.
connexons
4. gap junction also called electrical synapse are a. Each cell contains
chan- nels formed from . Each connexion is one connexon which
made of subunits each called . start from one cell goes
Con- nexin subunit has 4 domain that form through the
and 2 domain which mediate membrane and end in
bind- ing between 2 cells. Pore big enough the cleft
to fit ions (i.e. currents) & small signalling i. Two of these come
molecules such as cAMP or cGMP to- gether to form the
chan- nel
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6
connexin transmembrane pore extracellular
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5. there are members of connexin gene in 21
hu- mans. They have different isoforms in tissue
different 36
. connexin forms the gap electrical
junction at
synapse couple
6. One of the major role of gap junctions is to
cellular activity. Coupled cells tend to fire at Action
potentials the same time so they enhance between
synchronization cells.
7. synapse appear less common compared
Electrical to synapse. synapse are much
Chemical more complex compared to synapse
mean- Chemical
ing that they can be at many Electrical
levels which provides greater and Modified
flexibility
adaptability
8. Chemical synapse are diverse in 3 categories. Chemical
Name them? diversity size
target
9. Chemical Synapse Diversity few
1. Chemical diversity (the neurotransmitters that they bouton
use) zones
a. Excitatory, inhibitory, modulatory i. synapse a
the end of
2. Size an axon
a. Small (bouton, en-passant) - active are called
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ii. neuron joins another at a place beside the en-
axon terminal are called pessant
iii. Small impact on membrane potential dendrite
soma
axon
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