(PCB4683) questions and
answers
How is HIV transmitted? - answer Sexual contact
Needle Sharing
Blood Transfusions
Breastfeeding
Childbirth
Where are the majority of new HIV infections found? - answer Low
to middle-income countries
What percentage of children make up new infections? - answer
7%
What country has the largest number of people living with HIV
and the biggest declines in new infections ? - answer Africa
What is HIV? - answer obligate intracellular parasite
Which cells are vulnerable to HIV? - answer Dendritic cells
Effector helper T cells
Memory helper T cells
, (all carry CD4 & CCR5)
How does HIV initiate replication? - answer by binding to two
proteins on the surface of a host cell.
first to CD4, found on the surface of certain macrophages and T
cells
second to a coreceptor, which fuses the envelope around the
virion with the host cell membrane and spills the contents of the
virion into the cell.
What contents of the virion are spilled into the cell? - answer
viruses diploid genome and three proteins:
reverse transcriptase
integrase
protease
Reverse Transcriptase - answer transcribes the virus's RNA
genome into DNA
Integrase - answer splices the DNA genome into the host cell's
genome
Protease - answer plays a role in the preparation of new viral
proteins