LCCW Biochem 1
A - ANSWER: Vitamin K is responsible for the γ- carboxylation of Clotting factors. Which of these
enzyme is used for the (gamma) γ - carboxylation of Factor II, VII, IX and X
A) Vitamin K - dependent γ - glutamyl carboxylase
B) Vitamin K epoxide reductase enzyme
C) Vitamin k - independent γ - glutamyl carboxylase
D) Vitamin K epoxide dehydrogenase enzyme
E) Vitamin K Oxidase
B - ANSWER: Warfarin is used a blood thinner to prevent clot formation in patient prone to
thrombosis. What is the mechanism of action of Warfarin
A) Activates Vitamin K - dependent γ - glutamyl carboxylase
B) Inhibit Vitamin K epoxide reductase enzyme
C) Inhibits Vitamin k - independent γ - glutamyl carboxylase
D) Enhance Vitamin K epoxide dehydrogenase enzyme
E) Enhance Vitamin K Oxidase
C - ANSWER: James 15 years old male presents to the emergency because bleeding gum and
bruising of the skin. He was diagnosed with vitamin deficiency . Which of these vitamin is most likely
deficient in James ?
A) Vitamin A
B) Vitamin C
C) Vitamin K
D) Vitamin E
E) Vitamin B2
E - ANSWER: Which of these enzyme function as an acyl CoA transporter and its deficiency in in
human is rare.
A) Vitamin B1
B) Vitamin B2
,LCCW Biochem 1
C) Vitamin B9
D) Vitamin B3
E) Vitamin B5
A - ANSWER: Helen, a 35 years old female present to the clinic with hair shedding (Alopecia) ,
muscle pain, and bowel inflammation. She consumed multiple raw eggs daily as part of her diet
regimen. She determined to be deficient a vitamin responsible for carboxylation reaction. Which of
these vitamins is deficient in Helen
A) Vitamin B7
B) Vitamin B1
C) Vitamin B2
D) Vitamin B9
E) Vitamin B5
B - ANSWER: 22 years female present to the clinic with severe cystic acne . She has tried other
forms of treatment and some topical vitamin derivatives treatment which has failed. She asked that
she should be treated another form of these vitamin that is teratogenic.
Which vitamin is used in the treatment of acne
A) Vitamin A
B) Vitamin C
C) Vitamin K
D) Vitamin E
E) Vitamin B2
D - ANSWER: Which form of vitamin C is teratogenic ( fetal development malformation)?
A) Retinol
B) Retinal
C) All - trans retinoic Acid ( tretinoin)
D) 13 - cis retinoic acid (Isotretinoin)
E) Retinyl ester
,LCCW Biochem 1
B - ANSWER: The conversion of 25-hydroxycholecalciferol to calcitriol occur in in which of the
following organ
(A) Skin
(B) Liver
(C) Kidney
(D) Spleen
(E) Pancreas
C - ANSWER: conversion of 25-hydroxycholecalciferol to calcitriol occurs, which hormone mediate or
induce these conversion?
A) Growth hormone
B) Calcitonin
C) Parathyroid hormone
D) Prolactin
E) Thyroid hormone
A - ANSWER: Which of these compounds is the primary precursor for Calcitriol is found in the
epidermis and dermis
A) 7 -Dehydrocholesterol
B) Cholecalciferol
C) 25-Hydroxycholecalciferol
D)1,25- dihydrocholecaliferol
D - ANSWER: This Vitamin is an antioxidant that protects membrane lipids from peroxidation. It
deficiency can also lead retinitis pigmentosum, ataxia, peripheral neuropathy and hemolytic anemia.
Which of these vitamins is described above
A) Vitamin A
B) Vitamin C
, LCCW Biochem 1
C) Vitamin K
D) Vitamin E
E) Vitamin B2
E - ANSWER: Mr. Joe a 40 years old male present to the Clinic due occupational exposure to
Tuberculosis . The patient was given a PPD test and after 72 hours it was positive for induration and
size. The patient was started on Isoniazid daily for 6 -9 months. 3 months into his treatment he
started complaining of peripheral neuropathy, cheilosis or stomatitis ( cracking ,scaling of lips borders
and corner of the mouth). Which of these vitamins is deficient in Mr. Joe?
A) Pyridoxine
B) Pantothetic acid
C) Ascorbic Acid
D) Biotin
E) Niacin
D - ANSWER: Mr. Chen 50 years male brought to the emergency by the police because he was found
sleeping on the sidewalk and unresponsive to police command. He finally woke up in the Emergency
after given an IV solution containing vitamin and dextrose. He confabulates and has ataxic gait and
some form of nystagmus. Which vitamin is deficient in this patient?
A) Pyridoxine
B) Pantothetic acid
C) Ascorbic Acid
D) Thiamin
E) Folic Acid
D - ANSWER: Jenny 25 years old female present to the clinic because weakness , fatigue and muscle
aches. Her blood sample reveals MCV of > 100 . She was diagnosed with megaloblastic and
macrocytic anemia. She shows no neuropsychiatric or neurologic symptoms . Which of these is
lacking ?
A) Vitamin B 12 Cobalamin
B) Thiamin
A - ANSWER: Vitamin K is responsible for the γ- carboxylation of Clotting factors. Which of these
enzyme is used for the (gamma) γ - carboxylation of Factor II, VII, IX and X
A) Vitamin K - dependent γ - glutamyl carboxylase
B) Vitamin K epoxide reductase enzyme
C) Vitamin k - independent γ - glutamyl carboxylase
D) Vitamin K epoxide dehydrogenase enzyme
E) Vitamin K Oxidase
B - ANSWER: Warfarin is used a blood thinner to prevent clot formation in patient prone to
thrombosis. What is the mechanism of action of Warfarin
A) Activates Vitamin K - dependent γ - glutamyl carboxylase
B) Inhibit Vitamin K epoxide reductase enzyme
C) Inhibits Vitamin k - independent γ - glutamyl carboxylase
D) Enhance Vitamin K epoxide dehydrogenase enzyme
E) Enhance Vitamin K Oxidase
C - ANSWER: James 15 years old male presents to the emergency because bleeding gum and
bruising of the skin. He was diagnosed with vitamin deficiency . Which of these vitamin is most likely
deficient in James ?
A) Vitamin A
B) Vitamin C
C) Vitamin K
D) Vitamin E
E) Vitamin B2
E - ANSWER: Which of these enzyme function as an acyl CoA transporter and its deficiency in in
human is rare.
A) Vitamin B1
B) Vitamin B2
,LCCW Biochem 1
C) Vitamin B9
D) Vitamin B3
E) Vitamin B5
A - ANSWER: Helen, a 35 years old female present to the clinic with hair shedding (Alopecia) ,
muscle pain, and bowel inflammation. She consumed multiple raw eggs daily as part of her diet
regimen. She determined to be deficient a vitamin responsible for carboxylation reaction. Which of
these vitamins is deficient in Helen
A) Vitamin B7
B) Vitamin B1
C) Vitamin B2
D) Vitamin B9
E) Vitamin B5
B - ANSWER: 22 years female present to the clinic with severe cystic acne . She has tried other
forms of treatment and some topical vitamin derivatives treatment which has failed. She asked that
she should be treated another form of these vitamin that is teratogenic.
Which vitamin is used in the treatment of acne
A) Vitamin A
B) Vitamin C
C) Vitamin K
D) Vitamin E
E) Vitamin B2
D - ANSWER: Which form of vitamin C is teratogenic ( fetal development malformation)?
A) Retinol
B) Retinal
C) All - trans retinoic Acid ( tretinoin)
D) 13 - cis retinoic acid (Isotretinoin)
E) Retinyl ester
,LCCW Biochem 1
B - ANSWER: The conversion of 25-hydroxycholecalciferol to calcitriol occur in in which of the
following organ
(A) Skin
(B) Liver
(C) Kidney
(D) Spleen
(E) Pancreas
C - ANSWER: conversion of 25-hydroxycholecalciferol to calcitriol occurs, which hormone mediate or
induce these conversion?
A) Growth hormone
B) Calcitonin
C) Parathyroid hormone
D) Prolactin
E) Thyroid hormone
A - ANSWER: Which of these compounds is the primary precursor for Calcitriol is found in the
epidermis and dermis
A) 7 -Dehydrocholesterol
B) Cholecalciferol
C) 25-Hydroxycholecalciferol
D)1,25- dihydrocholecaliferol
D - ANSWER: This Vitamin is an antioxidant that protects membrane lipids from peroxidation. It
deficiency can also lead retinitis pigmentosum, ataxia, peripheral neuropathy and hemolytic anemia.
Which of these vitamins is described above
A) Vitamin A
B) Vitamin C
, LCCW Biochem 1
C) Vitamin K
D) Vitamin E
E) Vitamin B2
E - ANSWER: Mr. Joe a 40 years old male present to the Clinic due occupational exposure to
Tuberculosis . The patient was given a PPD test and after 72 hours it was positive for induration and
size. The patient was started on Isoniazid daily for 6 -9 months. 3 months into his treatment he
started complaining of peripheral neuropathy, cheilosis or stomatitis ( cracking ,scaling of lips borders
and corner of the mouth). Which of these vitamins is deficient in Mr. Joe?
A) Pyridoxine
B) Pantothetic acid
C) Ascorbic Acid
D) Biotin
E) Niacin
D - ANSWER: Mr. Chen 50 years male brought to the emergency by the police because he was found
sleeping on the sidewalk and unresponsive to police command. He finally woke up in the Emergency
after given an IV solution containing vitamin and dextrose. He confabulates and has ataxic gait and
some form of nystagmus. Which vitamin is deficient in this patient?
A) Pyridoxine
B) Pantothetic acid
C) Ascorbic Acid
D) Thiamin
E) Folic Acid
D - ANSWER: Jenny 25 years old female present to the clinic because weakness , fatigue and muscle
aches. Her blood sample reveals MCV of > 100 . She was diagnosed with megaloblastic and
macrocytic anemia. She shows no neuropsychiatric or neurologic symptoms . Which of these is
lacking ?
A) Vitamin B 12 Cobalamin
B) Thiamin
