NCD BBB NCD Due To Lewy Bodies / Parkinson
Dementia/Vascular NCD/ – Questions & A+
Solutions
A 72 y.o. male patient with cognitive impairment develops
frightening visual hallucinations. You prescribe low dose
risperidone. The patient develops severe bradykinesia, tremor,
rigidity, and gait disturbance. His adverse reaction suggests which
NCD diagnosis?
A. NCD due to Alzheimer's disease
B. NCD with Lewy bodies
C. Normal pressure hydrocephalus
D. NCD due to frontotemporal lobar degeneration
E. Vascular NCD Correct Answer - NCD with Lewy bodies
Which is the 2nd most common NCD ? Correct Answer -
Dementia with Lewey bodies (DLB) is the second most common
cause of dementia in the elderly
Alzheimers is the 1st one
An 80 y.o. woman has fluctuating levels of attention and cognition.
All causes of delirium have been assessed for and excluded. What
type of neurocognitive disorder is she most likely to have?
A. NCD due to Alzheimer's disease
B. NCD with Lewy bodies
C. NCD due to HIV infection
D. NCD due to Pick's disease
E. Vascular NCD Correct Answer - NCD with Lewy bodies
, What is the difference between NCD with Lewy bodies and NCD due
to Parkinson's disease ? Correct Answer - NCD with Lewy
bodies : COGNITIVE DECLINE FIRST THEN MOTOR SYMPTOMS
- Cognitive impairment and Parkinsonism occur together
- 20% of major NCDs; may be second most common major NCD
Parkinson MOTOR SYMPTOMS START AFTER cognitive decline -
• NCD due to Parkinson's disease . -- MOTOR FIRST THEN
COGNITIVE DECLINE
- Parkinson's motor disease present for 12 months before cognitive
impairment evident
- On spectrum with NCD with Lewy bodies
What is the Spectrum of Lewy Body Disorders Correct Answer -
NCD with Lewy bodies
NCD due to Parkinson's disease
Lewy body variant of Alzheimer's disease (LBV-AD)
What % of patients with Alzheimers disease have Lewy body variant
of Alzheimer's disease (LBV-AD) Correct Answer - - 40% of
Alzheimer patients have substantial Lewy bodies
- Presentation: mixture of Lewy body and Alzheimer's disease
presentations
Pathophysiology
• What are Lewy bodies? Correct Answer - Abnormal
aggregation of proteins: alpha synuclein, neurofilament, and
ubiquitin
Dementia/Vascular NCD/ – Questions & A+
Solutions
A 72 y.o. male patient with cognitive impairment develops
frightening visual hallucinations. You prescribe low dose
risperidone. The patient develops severe bradykinesia, tremor,
rigidity, and gait disturbance. His adverse reaction suggests which
NCD diagnosis?
A. NCD due to Alzheimer's disease
B. NCD with Lewy bodies
C. Normal pressure hydrocephalus
D. NCD due to frontotemporal lobar degeneration
E. Vascular NCD Correct Answer - NCD with Lewy bodies
Which is the 2nd most common NCD ? Correct Answer -
Dementia with Lewey bodies (DLB) is the second most common
cause of dementia in the elderly
Alzheimers is the 1st one
An 80 y.o. woman has fluctuating levels of attention and cognition.
All causes of delirium have been assessed for and excluded. What
type of neurocognitive disorder is she most likely to have?
A. NCD due to Alzheimer's disease
B. NCD with Lewy bodies
C. NCD due to HIV infection
D. NCD due to Pick's disease
E. Vascular NCD Correct Answer - NCD with Lewy bodies
, What is the difference between NCD with Lewy bodies and NCD due
to Parkinson's disease ? Correct Answer - NCD with Lewy
bodies : COGNITIVE DECLINE FIRST THEN MOTOR SYMPTOMS
- Cognitive impairment and Parkinsonism occur together
- 20% of major NCDs; may be second most common major NCD
Parkinson MOTOR SYMPTOMS START AFTER cognitive decline -
• NCD due to Parkinson's disease . -- MOTOR FIRST THEN
COGNITIVE DECLINE
- Parkinson's motor disease present for 12 months before cognitive
impairment evident
- On spectrum with NCD with Lewy bodies
What is the Spectrum of Lewy Body Disorders Correct Answer -
NCD with Lewy bodies
NCD due to Parkinson's disease
Lewy body variant of Alzheimer's disease (LBV-AD)
What % of patients with Alzheimers disease have Lewy body variant
of Alzheimer's disease (LBV-AD) Correct Answer - - 40% of
Alzheimer patients have substantial Lewy bodies
- Presentation: mixture of Lewy body and Alzheimer's disease
presentations
Pathophysiology
• What are Lewy bodies? Correct Answer - Abnormal
aggregation of proteins: alpha synuclein, neurofilament, and
ubiquitin
