NAMS MENOPAUSE
CERTIFICATION EXAM
QUESTIONS AND ANSWERS
, thermoregulatory center altered by
increase in KNDy neurons; activation of
NK3R causes hot flashes; blockade of
Physiology of VMS NK3R reduces/eliminates hot flashes; may
also be affected by:
serotonin, epinephrine, and norepinephrine;
parasympathetic nerve activity.
Off label rx for VMS SSRIs, SNRIs, Gabapentinoids, Clonidine,
Oxybutynin.
not FDA approved; vaginal symptoms and
Studies on Fractional sexual function scores increased
Co2 Laser for GSM significantly at 3 months; noted continued
improvement at 1 year.
for treatment of dyspareunia; decreases
vaginal pH; improves vaginal dryness;
Ospemifene (Osphena)
shifts vaginal maturational index to
indications and MOA
superficial cells; estrogen
agonist/antagonist.
Ospemifene (Osphena) increase in uterine polyps; proliferative
adverse effects endometrium; slight increased risk of
hemorrhagic stroke and VTE; can increase
VMS.
CERTIFICATION EXAM
QUESTIONS AND ANSWERS
, thermoregulatory center altered by
increase in KNDy neurons; activation of
NK3R causes hot flashes; blockade of
Physiology of VMS NK3R reduces/eliminates hot flashes; may
also be affected by:
serotonin, epinephrine, and norepinephrine;
parasympathetic nerve activity.
Off label rx for VMS SSRIs, SNRIs, Gabapentinoids, Clonidine,
Oxybutynin.
not FDA approved; vaginal symptoms and
Studies on Fractional sexual function scores increased
Co2 Laser for GSM significantly at 3 months; noted continued
improvement at 1 year.
for treatment of dyspareunia; decreases
vaginal pH; improves vaginal dryness;
Ospemifene (Osphena)
shifts vaginal maturational index to
indications and MOA
superficial cells; estrogen
agonist/antagonist.
Ospemifene (Osphena) increase in uterine polyps; proliferative
adverse effects endometrium; slight increased risk of
hemorrhagic stroke and VTE; can increase
VMS.
