BGZ2026 The Basic Principles of Pharmacology
Presentation text (notes used during the presentation under the slides)
+ Powerpoint of kinetics Lab training and the assignments for the
paracetamol study
1. Lab training ‘’Clinical study drug-nutrient interaction (‘paracetamol
study’)
2. Lab training kinetics – ‘’Beaker glass experiments’’
1. Lab training Paracetamol study
Report, practical “paracetamol study”
Group number: Tutorial number
Group 1, non-sober
Student names and student numbers
Paracetamol is a pain killer, which mechanism of action is not fully elucidated yet.
It is effective when the concentration of paracetamol in the plasma exceeds a
threshold value (in humans, this is about 3 mg/L), than the concentration is in the
range of the therapeutic window. Paracetamol is metabolized by the liver. After
some time, the concentration drops below the minimal effective concentration
(MEC).
It is assumed, that the effect of paracetamol depends on the way of
Research question addressed in the practical (try to be as accurate
as possible):
Is taking a dose of 1000 mg of paracetamol to treat a headache in young
adults aged 18-25 years, more effective (has a larger Cmax and lower Tmax)
when taken sober with a waiting time of one hour before a meal or when taken
after a meal?
administration.
Presentation text (notes used during the presentation under the slides)
+ Powerpoint of kinetics Lab training and the assignments for the
paracetamol study
1. Lab training ‘’Clinical study drug-nutrient interaction (‘paracetamol
study’)
2. Lab training kinetics – ‘’Beaker glass experiments’’
1. Lab training Paracetamol study
Report, practical “paracetamol study”
Group number: Tutorial number
Group 1, non-sober
Student names and student numbers
Paracetamol is a pain killer, which mechanism of action is not fully elucidated yet.
It is effective when the concentration of paracetamol in the plasma exceeds a
threshold value (in humans, this is about 3 mg/L), than the concentration is in the
range of the therapeutic window. Paracetamol is metabolized by the liver. After
some time, the concentration drops below the minimal effective concentration
(MEC).
It is assumed, that the effect of paracetamol depends on the way of
Research question addressed in the practical (try to be as accurate
as possible):
Is taking a dose of 1000 mg of paracetamol to treat a headache in young
adults aged 18-25 years, more effective (has a larger Cmax and lower Tmax)
when taken sober with a waiting time of one hour before a meal or when taken
after a meal?
administration.
