Connective tissue
Group of tissue that bind other tissues in the body
Composition of connective tissue
1. Cells
2. Matrix
a. Ground substance
b. Fibers
1.Cells
Specialized cells in connective tissue form and maintain the extracellular
Immature: blast - can reproduce and form the matrix
Mature: cyte - reduce ability to divide and maintain matrix
Bone remodeling: removal of existing bone by deposition of new bone bone by osteoblasts
Cells are grouped into
● Fixed cells
● Wandering cells
1. Fixed cells are
A. Fibrocyte/ fibroblast
● Responsible for formation of fibers
● Spindle fusi formed (youngest)
● Lamellar
● Stellate starlike (oldest)
● Blasts - fibroblasts form fibers, osteoblasts form bones, chondroblasts form cartilage
● Cytes - fibrocytes, osteocytes, chondrocytes
● Extracellular fibers and ground substances
, B. Fixed macrophage/ histiocytes
● Involved in phagocytosis
● Agents
● Macrophage or histiocytes: phagocytic WBC most abundant in the loose connective tissue. Difficult to
distinguish with fibroblasts unless they are performing phagocytic activity
● Phagocytosis of ECM components and debris
● Antigen processing and presentation to immune cells
● Secretion of growth factors, cytokines and other agents
C. Adipose/ fat cells
● Adipocytes store triglycerides. When adipose cells predominant the connective tissue is called adipose
tissue
● Store neutral fats
Group of tissue that bind other tissues in the body
Composition of connective tissue
1. Cells
2. Matrix
a. Ground substance
b. Fibers
1.Cells
Specialized cells in connective tissue form and maintain the extracellular
Immature: blast - can reproduce and form the matrix
Mature: cyte - reduce ability to divide and maintain matrix
Bone remodeling: removal of existing bone by deposition of new bone bone by osteoblasts
Cells are grouped into
● Fixed cells
● Wandering cells
1. Fixed cells are
A. Fibrocyte/ fibroblast
● Responsible for formation of fibers
● Spindle fusi formed (youngest)
● Lamellar
● Stellate starlike (oldest)
● Blasts - fibroblasts form fibers, osteoblasts form bones, chondroblasts form cartilage
● Cytes - fibrocytes, osteocytes, chondrocytes
● Extracellular fibers and ground substances
, B. Fixed macrophage/ histiocytes
● Involved in phagocytosis
● Agents
● Macrophage or histiocytes: phagocytic WBC most abundant in the loose connective tissue. Difficult to
distinguish with fibroblasts unless they are performing phagocytic activity
● Phagocytosis of ECM components and debris
● Antigen processing and presentation to immune cells
● Secretion of growth factors, cytokines and other agents
C. Adipose/ fat cells
● Adipocytes store triglycerides. When adipose cells predominant the connective tissue is called adipose
tissue
● Store neutral fats
