1
NCLEX-RN Practice Questions | 150
High-Yield NGN-Style MCQs with
Answers & Rationales | 2025 Nursing
Exam Prep
Question 1 You are caring for a client at the end of life. The client says their legally married
spouse can automatically make all healthcare decisions for them without needing a durable
power of attorney. The spouse disagrees, saying they can only decide on matters not documented
in the advance directive. What should you say as the nurse?
A. The spouse may override the advance directive only if the client is terminal.
B. All healthcare decisions are automatically deferred to the spouse, regardless of
documentation.
C. Only unanticipated treatments not included in the advance directive can be made by the
durable power of attorney. ✓
D. As the nurse, I can assist in changing the advance directive to reflect the spouse’s wishes.
, 2
Correct Answer: C
Question 2 The Patient Self-Determination Act of the United States protects clients’ rights in
which areas? (Select all that apply)
A. The right to receive treatment recommended by their healthcare provider.
B. The right to make healthcare decisions and have them communicated if they become
incompetent. ✓
C. The right to be fully informed about treatments, including benefits, risks, and alternatives. ✓
D. The right to select healthcare providers without coercion or undue influence. ✓
Correct Answers: B, C, D
Question 3 A client with severe trauma and burns has an advance directive requesting full life-
saving measures. During your shift, the client suffers a cardiac and respiratory arrest and has
little chance of survival. What should you do first?
A. Call the doctor to report the arrest and status change.
B. Begin CPR and emergency life-saving measures. ✓
C. Notify the family and ask what they want done.
D. Ensure the client is comfortable and without distress.
Correct Answer: B
Question 4 Your pregnant client has a new order for a medication. What principle should you
apply to this medication?
A. Drugs in categories C, D, and X are contraindicated in pregnancy. ✓
B. Drugs in categories A, B, and C are contraindicated in pregnancy.
C. Drugs in categories C, D, and E are contraindicated in pregnancy.
D. Drugs in categories C, D, and Z are contraindicated in pregnancy.
, 3
Correct Answer: A
Question 5 What are the nursing implications for a client with blood type B negative receiving
blood products?
A. The client has A and B agglutinins and lacks the Rh factor.
B. The client has B and O agglutinins and lacks the Rh factor.
C. The client has B agglutinins and lacks the Rh factor.
D. The client has A agglutinins and lacks the Rh factor. ✓
Correct Answer: D
Question 6 Select the complication of blood transfusion paired with its preventive measure:
A. Hemolysis: Typing and cross-matching before administration. ✓
B. Hemolysis: Ensuring the client had no history of hemolysis.
C. Febrile reactions: Ensuring the client had no history of hemolysis.
D. Febrile reactions: Typing and cross-matching before administration.
Correct Answer: A
Question 7 You are about to administer packed red blood cells. Which principle should guide
you?
A. Ensure a patent IV catheter of at least 20 gauge.
B. Have another nurse assist with the administration.
C. Start the unit within 1 hour of pickup.
D. Monitor the client for 30 minutes after the transfusion begins. ✓
Correct Answer: D
, 4
Question 8 Which type of venous access is most appropriate for a critically injured trauma client
needing long-term therapy and hyperalimentation?
A. Non-tunneled subclavian catheter
B. Peripheral IV catheter (20 gauge)
C. Multi-lumen tunneled, cuffed central catheter ✓
D. Peripherally inserted central catheter (PICC)
Correct Answer: C
Question 9 Doctor’s Order: 200 mg medication once daily. Medication label: 1 tablet = 150 mg.
How many tablets should be administered?
A. 1.5 tablets ✓
B. 1.25 tablets
C. 1.33 tablets
D. 1 tablet
Correct Answer: A
Question 10 Doctor’s Order: 10 mg BID. Medication label: 1 mL = 12 mg. How many mL
should be administered per dose?
A. 0.8 mL ✓
B. 0.9 mL
C. 0.75 mL
D. 0.125 mL
Correct Answer: A
Question 11 Your patient is at risk for fluid overload. Which order should the nurse question?
NCLEX-RN Practice Questions | 150
High-Yield NGN-Style MCQs with
Answers & Rationales | 2025 Nursing
Exam Prep
Question 1 You are caring for a client at the end of life. The client says their legally married
spouse can automatically make all healthcare decisions for them without needing a durable
power of attorney. The spouse disagrees, saying they can only decide on matters not documented
in the advance directive. What should you say as the nurse?
A. The spouse may override the advance directive only if the client is terminal.
B. All healthcare decisions are automatically deferred to the spouse, regardless of
documentation.
C. Only unanticipated treatments not included in the advance directive can be made by the
durable power of attorney. ✓
D. As the nurse, I can assist in changing the advance directive to reflect the spouse’s wishes.
, 2
Correct Answer: C
Question 2 The Patient Self-Determination Act of the United States protects clients’ rights in
which areas? (Select all that apply)
A. The right to receive treatment recommended by their healthcare provider.
B. The right to make healthcare decisions and have them communicated if they become
incompetent. ✓
C. The right to be fully informed about treatments, including benefits, risks, and alternatives. ✓
D. The right to select healthcare providers without coercion or undue influence. ✓
Correct Answers: B, C, D
Question 3 A client with severe trauma and burns has an advance directive requesting full life-
saving measures. During your shift, the client suffers a cardiac and respiratory arrest and has
little chance of survival. What should you do first?
A. Call the doctor to report the arrest and status change.
B. Begin CPR and emergency life-saving measures. ✓
C. Notify the family and ask what they want done.
D. Ensure the client is comfortable and without distress.
Correct Answer: B
Question 4 Your pregnant client has a new order for a medication. What principle should you
apply to this medication?
A. Drugs in categories C, D, and X are contraindicated in pregnancy. ✓
B. Drugs in categories A, B, and C are contraindicated in pregnancy.
C. Drugs in categories C, D, and E are contraindicated in pregnancy.
D. Drugs in categories C, D, and Z are contraindicated in pregnancy.
, 3
Correct Answer: A
Question 5 What are the nursing implications for a client with blood type B negative receiving
blood products?
A. The client has A and B agglutinins and lacks the Rh factor.
B. The client has B and O agglutinins and lacks the Rh factor.
C. The client has B agglutinins and lacks the Rh factor.
D. The client has A agglutinins and lacks the Rh factor. ✓
Correct Answer: D
Question 6 Select the complication of blood transfusion paired with its preventive measure:
A. Hemolysis: Typing and cross-matching before administration. ✓
B. Hemolysis: Ensuring the client had no history of hemolysis.
C. Febrile reactions: Ensuring the client had no history of hemolysis.
D. Febrile reactions: Typing and cross-matching before administration.
Correct Answer: A
Question 7 You are about to administer packed red blood cells. Which principle should guide
you?
A. Ensure a patent IV catheter of at least 20 gauge.
B. Have another nurse assist with the administration.
C. Start the unit within 1 hour of pickup.
D. Monitor the client for 30 minutes after the transfusion begins. ✓
Correct Answer: D
, 4
Question 8 Which type of venous access is most appropriate for a critically injured trauma client
needing long-term therapy and hyperalimentation?
A. Non-tunneled subclavian catheter
B. Peripheral IV catheter (20 gauge)
C. Multi-lumen tunneled, cuffed central catheter ✓
D. Peripherally inserted central catheter (PICC)
Correct Answer: C
Question 9 Doctor’s Order: 200 mg medication once daily. Medication label: 1 tablet = 150 mg.
How many tablets should be administered?
A. 1.5 tablets ✓
B. 1.25 tablets
C. 1.33 tablets
D. 1 tablet
Correct Answer: A
Question 10 Doctor’s Order: 10 mg BID. Medication label: 1 mL = 12 mg. How many mL
should be administered per dose?
A. 0.8 mL ✓
B. 0.9 mL
C. 0.75 mL
D. 0.125 mL
Correct Answer: A
Question 11 Your patient is at risk for fluid overload. Which order should the nurse question?
