USMLE UWorld Step 1 Questions with
complete correct verified Answers latest
updated version 2025 (Quiz Bank)
Nitroglycerin (nitrates) - symptomatic relief in chronic stable angina -
MOA? Adverse effects? --- correct precise answer ---Predominantly a
*venodilator*, also some arterial vasodilation - decreases both
preload & afterload (stroke volume maintained) -- NO ^cGMP,
decreasing intracellular Ca, dephosphorylating myosin light-chain,
relaxing vascular smooth muscle -- headaches, flushing,
lightheadedness, hypotension, reflex tachycardia --- nitroprusside can
cause cyanide toxicity
First line treatment for essential tremor --- correct precise answer ---
Propranolol
RAS signaling protein is active when bound to --- correct precise
answer ---GTP (ex: constitutively activated KRAS implicated in colon
cancer)
,Mullerian Aplasia --- correct precise answer ---No upper (therefore
short) vagina, variable uterine development. 46,XX females with
normal ovaries and 2ndary sexual characteristics
Physician's priority in domestic violence case --- correct precise
answer ---safety (emergency plan? safe place to go?) - don't confront
denial or pressure patient to disclose abuse or leave
Stroke in what brain area would cause complete contralateral
SENSORY loss --- correct precise answer ---Thalamus
Cause of lacunar infarcts --- correct precise answer ---small vessel
occlusion due to lipohyalinosis and microatheroma formation ->
lenticulostriate arteries <- uncontrolled HTN & DM
Cocaine MOA --- correct precise answer ---inhibits presynaptic
reuptake of NE,D,S (increased sympathetic activity); vasoconstrictor
(cause MI, sudden death)
Mutations associated with thyroid cancer: medullary vs follicular vs
anaplastic --- correct precise answer ---Medullary (RET), Follicular
(RAS), Anaplastic (p53)
,Dynein vs Kinesin - molecular motor proteins
(nerve axonal transport direction) --- correct precise answer ---
Dynein (periphery->center, + to -, retrograde)
Kinesin (center->periphery, - to +, anterograde)
Negative end Near Nucleus
Positive end Points to Periphery
Treatment of choice for behavioral symptoms of delirium --- correct
precise answer ---low dose antipsychotic (haloperidol)
Adenosine & Dypyridamole --- correct precise answer ---selective
vasodilators of all coronary vessels, can cause coronary steal
syndrome (hypoperfusion & worsening of existing myocardial
ischemia)
Treatment of choice for status epilepticus? (single seizure lasting >5
minutes or multiple discrete seizures with incomplete recovery
between episodes) --- correct precise answer ---IV benzodiazepine
(like lorazepam) ...to stop the seizure, then concurrently begin
phenytoin to prevent recurrence
, Pellagra --- correct precise answer ---*Vitamin B3 (Niacin) deficiency
- diarrhea, dermatitis, dementia* - precursor for NAD & NADP
(cofactors for many dehydrogenase and reductase enzymes) - seen in
those with poor nutrition (alcoholics) or corn-heavy diets - Niacin can
be synthesized endogenously from *tryptophan*
Stimulation of what nerve will move bulky tongue out of the way in
obstructive sleep apnea? --- correct precise answer ---Hypoglossal
Femoral nerve block (location) --- correct precise answer ---Inguinal
crease at lateral border of femoral artery - numbs anterior thigh,
quads, femur, knee
Pudendal nerve block (anatomic landmark / location) for delivery?
Presentation of stretch injury? --- correct precise answer ---Ischial
spine tip - for vaginal deliveries
Decreased sensation in perineum and genital area; can cause
fecal/urinary incontinence (pudendal normally controls external
sphincters) - although, most common cause of anal incontinence after
childbirth is sphincter damage
complete correct verified Answers latest
updated version 2025 (Quiz Bank)
Nitroglycerin (nitrates) - symptomatic relief in chronic stable angina -
MOA? Adverse effects? --- correct precise answer ---Predominantly a
*venodilator*, also some arterial vasodilation - decreases both
preload & afterload (stroke volume maintained) -- NO ^cGMP,
decreasing intracellular Ca, dephosphorylating myosin light-chain,
relaxing vascular smooth muscle -- headaches, flushing,
lightheadedness, hypotension, reflex tachycardia --- nitroprusside can
cause cyanide toxicity
First line treatment for essential tremor --- correct precise answer ---
Propranolol
RAS signaling protein is active when bound to --- correct precise
answer ---GTP (ex: constitutively activated KRAS implicated in colon
cancer)
,Mullerian Aplasia --- correct precise answer ---No upper (therefore
short) vagina, variable uterine development. 46,XX females with
normal ovaries and 2ndary sexual characteristics
Physician's priority in domestic violence case --- correct precise
answer ---safety (emergency plan? safe place to go?) - don't confront
denial or pressure patient to disclose abuse or leave
Stroke in what brain area would cause complete contralateral
SENSORY loss --- correct precise answer ---Thalamus
Cause of lacunar infarcts --- correct precise answer ---small vessel
occlusion due to lipohyalinosis and microatheroma formation ->
lenticulostriate arteries <- uncontrolled HTN & DM
Cocaine MOA --- correct precise answer ---inhibits presynaptic
reuptake of NE,D,S (increased sympathetic activity); vasoconstrictor
(cause MI, sudden death)
Mutations associated with thyroid cancer: medullary vs follicular vs
anaplastic --- correct precise answer ---Medullary (RET), Follicular
(RAS), Anaplastic (p53)
,Dynein vs Kinesin - molecular motor proteins
(nerve axonal transport direction) --- correct precise answer ---
Dynein (periphery->center, + to -, retrograde)
Kinesin (center->periphery, - to +, anterograde)
Negative end Near Nucleus
Positive end Points to Periphery
Treatment of choice for behavioral symptoms of delirium --- correct
precise answer ---low dose antipsychotic (haloperidol)
Adenosine & Dypyridamole --- correct precise answer ---selective
vasodilators of all coronary vessels, can cause coronary steal
syndrome (hypoperfusion & worsening of existing myocardial
ischemia)
Treatment of choice for status epilepticus? (single seizure lasting >5
minutes or multiple discrete seizures with incomplete recovery
between episodes) --- correct precise answer ---IV benzodiazepine
(like lorazepam) ...to stop the seizure, then concurrently begin
phenytoin to prevent recurrence
, Pellagra --- correct precise answer ---*Vitamin B3 (Niacin) deficiency
- diarrhea, dermatitis, dementia* - precursor for NAD & NADP
(cofactors for many dehydrogenase and reductase enzymes) - seen in
those with poor nutrition (alcoholics) or corn-heavy diets - Niacin can
be synthesized endogenously from *tryptophan*
Stimulation of what nerve will move bulky tongue out of the way in
obstructive sleep apnea? --- correct precise answer ---Hypoglossal
Femoral nerve block (location) --- correct precise answer ---Inguinal
crease at lateral border of femoral artery - numbs anterior thigh,
quads, femur, knee
Pudendal nerve block (anatomic landmark / location) for delivery?
Presentation of stretch injury? --- correct precise answer ---Ischial
spine tip - for vaginal deliveries
Decreased sensation in perineum and genital area; can cause
fecal/urinary incontinence (pudendal normally controls external
sphincters) - although, most common cause of anal incontinence after
childbirth is sphincter damage
