CLINICAL PHARMACOLOGY EXAM TEST QUESTIONS
WITH CORRECT SOLUTINS 2023-2024 UPDATE A GRADED
1. A seemingly harmless substance may cause acute inflammation under which of these circumstances?
a. The substance suddenly becomes harmful.
There’s abnormal deployment of the immune response against the
b.
substance.
c. The patient has become immunodeficient.
d. The patient suffers from malignant cancer.
2. The initial reaction to an inflammatory stimulus is in nature.
a. Psychological
b. Vascular
c. Cellular
, d. Suggestive
3. Which of the following is not included in the cardinal clinical signs of inflammation
a. Pain
b. Pruritus
c. Swelling
d. Heat
4. Histamine may be released by the following cells, EXCEPT:
a. Mast cells
b. Histaminocytes
c. Histiocytes
d. Histaminergic neurons
5. Histamine is most likely to mediate which of these
a. Initial vascular responses to
reactions?
acute
inflammation
b. Late vascular stages to acute inflammation
c. Pain
d. Cellular responses to acute inflammation
6. Blockade of H1 histamine receptors by diphenhydramine (Benadryl) at the usual clinical dose is most
likely to produce these effects EXCEPT:
a. drowsiness
b. relief of pruritus
reduction of gastric
c.
secretion
d. reduction of respiratory tract secretion
7. Which one of the following is NOT a way of counteracting the inflammatory effects of histamine?
a. Inhibiting secretion of histamine
, b. Histamine receptor blockade
c. Reversing the physiological effects of histamine
d.Stimulating cholinergic
receptors
8. The therapeutic benefits of a nonsteroidal anti-
inflammatory drug (NSAID) is best attained by it specific actions on:
a. Cyclooxygenase 1 (COX1)
b. COX 2
c. Lipooxygenease
d. Phospholipase A2
9. A glucococorticoid such as prednisolone inhibits:
a. Prostaglandins
b. Leukotrienes
Both prostaglandins and
c.
leukotrienes
d. Neither prostaglandins and leukotrienes
10. A typical NSAID has these pharmacologic actions, EXCEPT:
a. Antipruritic
b. Analgesic
c. Antiinflammatory
d. Antipyretic
11. Most of the adverse side effects of NSAIDs are consequent to their inhibitory effect of:
b. COX 2 a. COX 1
c. Lipooxygenease
d. Phospholipase A2
12. Which of these pharmacologic features is attributed to paracetamol?
a. Antipyretic, anti-inflammatory, analgesic
b. Antipyretic, analgesic but not anti-
inflammatory
c. Analgesic but not antipyretic
d. An opioid analgesic
WITH CORRECT SOLUTINS 2023-2024 UPDATE A GRADED
1. A seemingly harmless substance may cause acute inflammation under which of these circumstances?
a. The substance suddenly becomes harmful.
There’s abnormal deployment of the immune response against the
b.
substance.
c. The patient has become immunodeficient.
d. The patient suffers from malignant cancer.
2. The initial reaction to an inflammatory stimulus is in nature.
a. Psychological
b. Vascular
c. Cellular
, d. Suggestive
3. Which of the following is not included in the cardinal clinical signs of inflammation
a. Pain
b. Pruritus
c. Swelling
d. Heat
4. Histamine may be released by the following cells, EXCEPT:
a. Mast cells
b. Histaminocytes
c. Histiocytes
d. Histaminergic neurons
5. Histamine is most likely to mediate which of these
a. Initial vascular responses to
reactions?
acute
inflammation
b. Late vascular stages to acute inflammation
c. Pain
d. Cellular responses to acute inflammation
6. Blockade of H1 histamine receptors by diphenhydramine (Benadryl) at the usual clinical dose is most
likely to produce these effects EXCEPT:
a. drowsiness
b. relief of pruritus
reduction of gastric
c.
secretion
d. reduction of respiratory tract secretion
7. Which one of the following is NOT a way of counteracting the inflammatory effects of histamine?
a. Inhibiting secretion of histamine
, b. Histamine receptor blockade
c. Reversing the physiological effects of histamine
d.Stimulating cholinergic
receptors
8. The therapeutic benefits of a nonsteroidal anti-
inflammatory drug (NSAID) is best attained by it specific actions on:
a. Cyclooxygenase 1 (COX1)
b. COX 2
c. Lipooxygenease
d. Phospholipase A2
9. A glucococorticoid such as prednisolone inhibits:
a. Prostaglandins
b. Leukotrienes
Both prostaglandins and
c.
leukotrienes
d. Neither prostaglandins and leukotrienes
10. A typical NSAID has these pharmacologic actions, EXCEPT:
a. Antipruritic
b. Analgesic
c. Antiinflammatory
d. Antipyretic
11. Most of the adverse side effects of NSAIDs are consequent to their inhibitory effect of:
b. COX 2 a. COX 1
c. Lipooxygenease
d. Phospholipase A2
12. Which of these pharmacologic features is attributed to paracetamol?
a. Antipyretic, anti-inflammatory, analgesic
b. Antipyretic, analgesic but not anti-
inflammatory
c. Analgesic but not antipyretic
d. An opioid analgesic
