Summary Harpers illustrated biochemistry

,Contents
Preface xi


S E C T I O N
10 Bioinformatics & Computational
Biology 97

I
Structures & Functions of
Proteins & Enzymes 1 Peter J. Kennelly, PhD & Victor W. Rodwell, PhD



1 Biochemistry & Medicine 1 S E C T I O N



III
Victor W. Rodwell, PhD & Robert K. Murray, MD, PhD
Bioenergetics 113
2 Water & pH 6
Peter J. Kennelly, PhD & Victor W. Rodwell, PhD
11 Bioenergetics: The Role of ATP 113
3 Amino Acids & Peptides 15 Kathleen M. Botham, PhD, DSc & Peter A. Mayes, PhD, DSc
Peter J. Kennelly, PhD & Victor W. Rodwell, PhD
12 Biologic Oxidation 119
4 Proteins: Determination of Primary Kathleen M. Botham, PhD, DSc & Peter A. Mayes, PhD, DSc
Structure 25
Peter J. Kennelly, PhD & Victor W. Rodwell, PhD 13 The Respiratory Chain & Oxidative
Phosphorylation 126
5 Proteins: Higher Orders of Structure 36 Kathleen M. Botham, PhD, DSc & Peter A. Mayes, PhD, DSc
Peter J. Kennelly, PhD & Victor W. Rodwell, PhD



S E C T I O N



IV
S E C T I O N Metabolism of
Enzymes: Kinetics,

II
Carbohydrates 139
Mechanism, Regulation,
& Bioinformatics 51
14 Overview of Metabolism & the Provision
6 Proteins: Myoglobin & Hemoglobin 51 of Metabolic Fuels 139
Peter J. Kennelly, PhD & Victor W. Rodwell, PhD David A. Bender, PhD & Peter A. Mayes, PhD, DSc


7 Enzymes: Mechanism of Action 60 15 Carbohydrates of Physiological
Peter J. Kennelly, PhD & Victor W. Rodwell, PhD Significance 152
David A. Bender, PhD & Peter A. Mayes, PhD, DSc
8 Enzymes: Kinetics 73
Peter J. Kennelly, PhD & Victor W. Rodwell, PhD 16 The Citric Acid Cycle: The Central Pathway
of Carbohydrate, Lipid & Amino Acid
9 Enzymes: Regulation of Activities 87 Metabolism 161
Peter J. Kennelly, PhD & Victor W. Rodwell, PhD David A. Bender, PhD & Peter A. Mayes, PhD, DSc

, CONTENTS




17 Glycolysis & the Oxidation of Pyruvate 168 28 Catabolism of Proteins & of Amino Acid
David A. Bender, PhD & Peter A. Mayes, PhD, DSc Nitrogen 287
Victor W. Rodwell, PhD
18 Metabolism of Glycogen 176
David A. Bender, PhD & Peter A. Mayes, PhD, DSc 29 Catabolism of the Carbon Skeletons of
Amino Acids 297
19 Gluconeogenesis & the Control of Blood Victor W. Rodwell, PhD
Glucose 185
David A. Bender, PhD & Peter A. Mayes, PhD, DSc 30 Conversion of Amino Acids to Specialized
Products 313
20 The Pentose Phosphate Pathway & Other Victor W. Rodwell, PhD
Pathways of Hexose Metabolism 196
David A. Bender, PhD & Peter A. Mayes, PhD, DSc 31 Porphyrins & Bile Pigments 323
Victor W. Rodwell, PhD & Robert K. Murray, MD, PhD

S E C T I O N



V Metabolism of Lipids 211
S E C T I O N
Structure, Function, &

21 Lipids of Physiologic Significance 211
Kathleen M. Botham, PhD, DSc & Peter A. Mayes, PhD, DSc
VII Replication of Informational
Macromolecules 339

32 Nucleotides 339
22 Oxidation of Fatty Acids: Ketogenesis 223 Victor W. Rodwell, PhD
Kathleen M. Botham, PhD, DSc & Peter A. Mayes, PhD, DSc
33 Metabolism of Purine & Pyrimidine
23 Biosynthesis of Fatty Nucleotides 347
Acids & Eicosanoids 232 Victor W. Rodwell, PhD
Kathleen M. Botham, PhD, DSc & Peter A. Mayes, PhD, DSc
34 Nucleic Acid Structure & Function 359
24 Metabolism of Acylglycerols P. Anthony Weil, PhD
& Sphingolipids 245
Kathleen M. Botham, PhD, DSc & Peter A. Mayes, PhD, DSc 35 DNA Organization, Replication,
& Repair 370
25 Lipid Transport & Storage 253 P. Anthony Weil, PhD
Kathleen M. Botham, PhD, DSc & Peter A. Mayes, PhD, DSc
36 RNA Synthesis, Processing,
26 Cholesterol Synthesis, Transport, & Modification 394
& Excretion 266 P. Anthony Weil, PhD
Kathleen M. Botham, PhD, DSc & Peter A. Mayes, PhD, DSc
37 Protein Synthesis & the Genetic Code 413
P. Anthony Weil, PhD
S E C T I O N



VI
Metabolism of Proteins
& Amino Acids 281 38 Regulation of Gene Expression 428
P. Anthony Weil, PhD


27 Biosynthesis of the Nutritionally 39 Molecular Genetics, Recombinant DNA,
Nonessential Amino Acids 281 & Genomic Technology 451
Victor W. Rodwell, PhD P. Anthony Weil, PhD

, CONTENTS




S E C T I O N S E C T I O N
Biochemistry of

VIII Extracellular & Intracellular
Communication 477 X Special Topics (B) 607


40 Membranes: Structure 49 Intracellular Traffic & Sorting of Proteins 607
& Function 477 Kathleen M. Botham , PhD, DSc & Robert K. Murray, MD, PhD
Robert K. Murray, MD, PhD & P. Anthony Weil, PhD
50 The Extracellular Matrix 627
41 The Diversity of the Endocrine Kathleen M. Botham, PhD, DSc & Robert K. Murray, MD, PhD
System 498
P. Anthony Weil, PhD 51 Muscle & the Cytoskeleton 647
Peter J. Kennelly, PhD & Robert K. Murray, MD, PhD
42 Hormone Action & Signal
Transduction 518 52 Plasma Proteins & Immunoglobulins 668
P. Anthony Weil, PhD Peter J. Kennelly, PhD, Robert K. Murray, MD, PhD, Molly
Jacob, MBBS, MD, PhD & Joe Varghese, MBBS, MD


53 Red Blood Cells 689
S E C T I O N Peter J. Kennelly, PhD & Robert K. Murray, MD, PhD



IX Special Topics (A) 537
54 White Blood Cells 700
Peter J. Kennelly, PhD & Robert K. Murray, MD, PhD


43 Nutrition, Digestion,
& Absorption 537 S E C T I O N
David A. Bender, PhD & Peter A. Mayes , PhD, DSc


44 Micronutrients: Vitamins XI Special Topics (C) 711

& Minerals 546
David A. Bender, PhD 55 Hemostasis & Thrombosis 711
Peter L. Gross, MD, MSc, FRCP(C), Robert K. Murray, MD, PhD,
P. Anthony Weil, PhD, & Margaret L. Rand, PhD
45 Free Radicals & Antioxidant
Nutrients 564
David A. Bender, PhD 56 Cancer: An Overview 722
Molly Jacob, MBBS, MD, PhD, Joe Varghese, MBBS, MD,
Robert K. Murray, MD, PhD & P. Anthony Weil, PhD
46 Glycoproteins 569
David A. Bender, PhD & Robert K. Murray, MD, PhD
57 Biochemical Case Histories 746
David A. Bender, PhD
47 Metabolism of Xenobiotics 583
David A. Bender, PhD & Robert K. Murray, MD, PhD
58 The Biochemistry of Aging 755
Peter J. Kennelly, PhD
48 Clinical Biochemistry 589
David A. Bender, PhD, Joe Varghese, MBBS, MD,
Molly Jacob, MBBS, MD, PhD, & Robert K. The Answer Bank 771
Murray, MD, PhD Index 777