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What 2 ways are tumor markers present? ---------CORRECT ANSWER-----------------
1. Antigens expressed on he surface of tumor cells
2. Substances released from normal cells in response to the presence of a tumor
What 3 ways are tumor markers used? ---------CORRECT ANSWER-----------------1.
Establishing prognosis
2. Monitoring treatment
3. Detecting recurrent disease
What are some limitations of tumor markers? ---------CORRECT ANSWER-------------
----1. Under benign conditions, most tumor markers can be elevated
2. Most markers are not elevated in the early stages of malignancy
After treatment of cancer, if tumor markers begin to rise, this can indicate what? -
--------CORRECT ANSWER-----------------A recurrence of cancer
,Pap tests are primarily used for cervical cancer screenings, but may be used on
other secretions. What are they? ---------CORRECT ANSWER-----------------
Pleural/peritoneal fluid, nipple drainage, gastric and anal washings
Tissue biopsies can be obtained through a variety of methods. Name a few. --------
-CORRECT ANSWER-----------------1. Needle
2. Endoscopic methods
3. Laparoscopic methods
What is excisional biopsy? ---------CORRECT ANSWER-----------------Removes part or
all of the tumor thru a surgical incision
What is a fine-needle aspiration? ---------CORRECT ANSWER-----------------Removing
cells and fluid with a small-bore needle and syringe (used commonly in thyroid,
breast, and lymphnodes)
What is immunohistochemistry? ---------CORRECT ANSWER-----------------Uses
antibodies which recognize and bind to a specific cell products or surface markers
to correctly ID the desired antigens
Why is immunochemistry helpful to cancer diagnosis? ---------CORRECT ANSWER---
--------------helpful in determining the site of origin of metastatic tumors by
,determining which tissues, or even organs, in the surrounding area contain the
same antigens
What do microarray technologies use? ---------CORRECT ANSWER-----------------uses
"gene chips" that can simultaneously perform hundreds or even thousands of
miniature assays to detect and quantify the expression levels of a large number of
genes
What are the 2 broad categories of malignant neoplasms? ---------CORRECT
ANSWER-----------------1. Solid tumors
2. Hematologic cancers
What do solid tumors initially do? ---------CORRECT ANSWER-----------------They are
confined to a specific organ or tissue
What is metastasis? ---------CORRECT ANSWER-----------------As tumor growth
continues, cells detach, invade the surrounding tissue, and enter the blood and
lymph systems to spread to other sites
Hematologic cancers involve _________ and have already _______ in throughout
the body ---------CORRECT ANSWER-----------------Blood and lymph systems; spread
, Benign and malignant neoplasms are distinguished by which 5 traits? ---------
CORRECT ANSWER-----------------(1) cell characteristics
(2) rate of growth
(3) manner of growth
(4) capacity to invade and metastasize to other parts of the body
(5) potential for causing death
The suffix _____ refers to the tissue type from which an abnormal growth
originiates ---------CORRECT ANSWER------------------oma
_______ is a benign tumor of glandular epithelial tissues. ---------CORRECT
ANSWER-----------------Adenoma
________ is a benign tumor of bone tissue. ---------CORRECT ANSWER-----------------
Osteoma
__________ is a benign finger-like projection that grows on any surface. ---------
CORRECT ANSWER-----------------Papilloma