Murphy Biochem Rutgers Exam 2 questions with answers

Murphy Biochem Rutgers Exam 2 questions |\ |\ |\ |\ |\ |\




with answers |\




Place the following reaction intermediates of the CAC in
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chronological order |\




i. malate ii. fumarate iii. succinyl CoA iv. citrate v. a-ketoglutarate
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- CORRECT ANSWERS ✔✔iv, v, iii, ii, i
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Oxalosuccinate is a transient intermediate formed during which |\ |\ |\ |\ |\ |\ |\ |\


of the following reactions? - CORRECT ANSWERS ✔✔isocitrate to
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a-ketoglutarate


FADH2 is a product of which of the following reactions? -
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CORRECT ANSWERS ✔✔succinate to fumarate |\ |\ |\ |\




NADH is produced in which of the following reactions? - CORRECT
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ANSWERS ✔✔a-ketoglutarate to succinyl CoA
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Which of the following reactions can be described as anaplerotic?
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- CORRECT ANSWERS ✔✔pyruvate + co2 to oxaloacetate
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The enzymes that are unique to the glyoxylate cycle include
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____________ - CORRECT ANSWERS ✔✔isocitrate lyase |\ |\ |\ |\ |\




The regulated enzyme of the CAC include _________ - CORRECT
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ANSWERS ✔✔a-ketoglutarate dehydrogenase |\ |\

,The enzymes involved in citrate metabolism include all of the
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following except ________ - CORRECT ANSWERS ✔✔malate
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synthase


Redox potential is best defined as - CORRECT ANSWERS ✔✔the
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tendency of a species to gain or lose electrons
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In order to determine the standard voltage of a reaction -
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CORRECT ANSWERS ✔✔the standard cells must be written as
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they occur in the reaction and the voltages are added
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Which of the following reactions is an oxidation reaction?
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a. NaOH + HCl -> NaCl + H2O
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b. CH3COOH -> CH3COO- + H+
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c. CH3CHO -> CH3CH2OH
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d. CH3CH2OH -> CH3CHO
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e. CH2=CH2 + H2O -> CH3CH2OH - CORRECT ANSWERS
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✔✔CH3CH2OH -> CH3CHO |\ |\




Which of the following reactions has an oxidized product?
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a. carboxylic acid -> aldehyde
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b. R-SH + R-SH -> R-S-S-R
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c. alcohol -> ketone
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d. glutamate -> a-ketoglutarate
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e. none of the above - CORRECT ANSWERS ✔✔none of the above
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,In any redox reaction, an electron donor is - CORRECT ANSWERS
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✔✔the reducing agent |\ |\




In an redox reaction, an electron acceptor is - CORRECT
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ANSWERS ✔✔converted to an electron donor with the gain of one
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or more electrons
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Each turn of the CAC produces how many moles of CO2? -
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CORRECT ANSWERS ✔✔2 |\ |\




Acetyl CoA that is consumed by the CAC is produced from which
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of the following biochemical pathways?
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a. glycolysis
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b. fatty acid oxidation
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c. purine catabolism
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d. urea cycle
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e. both A and B are correct - CORRECT ANSWERS ✔✔both A and
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B are correct
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Which of the following is the strongest reducing agent?
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a. FADH2 (+ 0.22 V)
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b. H2 (+ 0.424 V)
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c. cytochrome a * Fe 2+ (-0.29 V)
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d. lactate (+0.19 V)
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e. H2O (-0.82 V) - CORRECT ANSWERS ✔✔H2
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, Which of the following reacts with the acetyl-CoA to form citrate?
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- CORRECT ANSWERS ✔✔oxaloacetate
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The redox reaction in which succinate is converted to fumarate
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uses FAD rather than NAD+ because? - CORRECT ANSWERS
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✔✔FAD is a stronger oxidizing agent than NAD+
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Which of the following CAC enzymes are closely regulated?
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a. citrate synthase
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b. isocitrate dehydrogenase
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c. a-ketoglutarate dehydrogenase
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d. both A and B are correct
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e. A, B, and C are all correct - CORRECT ANSWERS ✔✔A, B, and C
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are all correct
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Which of the following requires GDP? - CORRECT ANSWERS
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✔✔succinyl-CoA to succinate |\ |\




How many oxidation steps are there in the CAC? - CORRECT
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ANSWERS ✔✔4 |\




Which of the following is a cofactor for the conversion of
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succinate to fumarate? - CORRECT ANSWERS ✔✔FAD|\ |\ |\ |\ |\ |\