GMS 6504 MODULE 1-3 Exam 1 Latest
Questions with Correct Solutions- Ace Your
Grades.
What are System Independent Parameters? - Correct Answer-Affinity
| | | | | | |
Efficacy
What are the parts of a system that are identified as System Dependent
| | | | | | | | | | | |
Parameters? - Correct Answer-Number of receptors | | | | |
Cellular machinery
|
Presence of other drugs | | |
- Competitive
- Noncompetitive
Affinity is - Correct Answer-Thermokinetic propensity of drug to bind to
| | | | | | | | | |
receptor
Based largely on ΔG
| | |
Efficacy is - Correct Answer-Magnitude of change of receptor
| | | | | | | |
shape/function upon drug binding | | |
,Based on atom/atom interactions
| | |
What is the Occupancy Theory? - Correct Answer-Response is proportional
| | | | | | | | |
to fraction of receptors that are occupied
| | | | | |
100% response is obtained when all receptors have ligand
| | | | | | | |
What formula do we use to predict occupancy? - Correct Answer-Langmuir
| | | | | | | | | |
equation
DR/Rt = r = D/D+Kd| | | |
How do we define response effect? - Correct Answer-A+R --> (AR)
| | | | | | | | | |
Intrinsic activity is depicted as what letter?
| | | | | |
How is it defined? - Correct Answer-Alpha
| | | | | |
Multiplication factor describing ability of agonist to produce a stimulus
| | | | | | | | |
, In terms of intrinsic activity, what is determined to be a full agonist? -
| | | | | | | | | | | | |
Correct Answer-α = 1 | | |
In terms of intrinsic activity, what is determined to me a partial agonist? -
| | | | | | | | | | | | |
Correct Answer-0 < α < 1 | | | | |
In terms of intrinsic activity, what is determined to be an antagonist? -
| | | | | | | | | | | |
Correct Answer-α = 0 | | |
What is the formula for the estimation of relative efficacy? - Correct
| | | | | | | | | | |
Answer-R = f ( α x r x Rt ) | | | | | | | | |
f = stimulus response
| | |
Rt = receptor number
| | |
What is the Two State Theory? - Correct Answer-Binding of a ligand to a
| | | | | | | | | | | | |
receptor causes a conformational change
| | | |
A + R --> <-- AR closed --> <-- AR open
| | | | | | | | | |
Questions with Correct Solutions- Ace Your
Grades.
What are System Independent Parameters? - Correct Answer-Affinity
| | | | | | |
Efficacy
What are the parts of a system that are identified as System Dependent
| | | | | | | | | | | |
Parameters? - Correct Answer-Number of receptors | | | | |
Cellular machinery
|
Presence of other drugs | | |
- Competitive
- Noncompetitive
Affinity is - Correct Answer-Thermokinetic propensity of drug to bind to
| | | | | | | | | |
receptor
Based largely on ΔG
| | |
Efficacy is - Correct Answer-Magnitude of change of receptor
| | | | | | | |
shape/function upon drug binding | | |
,Based on atom/atom interactions
| | |
What is the Occupancy Theory? - Correct Answer-Response is proportional
| | | | | | | | |
to fraction of receptors that are occupied
| | | | | |
100% response is obtained when all receptors have ligand
| | | | | | | |
What formula do we use to predict occupancy? - Correct Answer-Langmuir
| | | | | | | | | |
equation
DR/Rt = r = D/D+Kd| | | |
How do we define response effect? - Correct Answer-A+R --> (AR)
| | | | | | | | | |
Intrinsic activity is depicted as what letter?
| | | | | |
How is it defined? - Correct Answer-Alpha
| | | | | |
Multiplication factor describing ability of agonist to produce a stimulus
| | | | | | | | |
, In terms of intrinsic activity, what is determined to be a full agonist? -
| | | | | | | | | | | | |
Correct Answer-α = 1 | | |
In terms of intrinsic activity, what is determined to me a partial agonist? -
| | | | | | | | | | | | |
Correct Answer-0 < α < 1 | | | | |
In terms of intrinsic activity, what is determined to be an antagonist? -
| | | | | | | | | | | |
Correct Answer-α = 0 | | |
What is the formula for the estimation of relative efficacy? - Correct
| | | | | | | | | | |
Answer-R = f ( α x r x Rt ) | | | | | | | | |
f = stimulus response
| | |
Rt = receptor number
| | |
What is the Two State Theory? - Correct Answer-Binding of a ligand to a
| | | | | | | | | | | | |
receptor causes a conformational change
| | | |
A + R --> <-- AR closed --> <-- AR open
| | | | | | | | | |
