INTRODUCTION OF
GRANULATION
FOR TABLET MANUFACTURING
1|Page
, INTRODUCTION
Granules are preparations consisting of solid, dry aggregates of powder particles sufficiently
resistant to withstand handling. They are intended for oral administration. Some are another
suitable liquid before being administered.
Granulation is the process in which primary powder particles are made to adhere to form
larger, multiparticle entities called granules.
Pharmaceutical granules typically have a size range between 0.2 and 4.0 mm, depending on
their subsequent use. In the majority of cases this will be in the production of tablets or
capsules, when granules will be made as an intermediate product and have a typical size range
between 0.2 and 0.5 mm, but larger granules are used as a dosage form in their own right.
Granules contain one or more active substances with or without excipients and, if necessary,
suitable colouring and flavouring substances. They are mainly used for low-toxicity, high-dose
drugs.
Granulation normally commences after initial dry mixing of the necessary powdered
ingredients so that a uniform distribution of each ingredient through the mix is achieved. After
granulation the granules will either be packed (when used as a dosage form), or they may be
mixed with other excipients prior to tablet compaction or capsule filling.
DIAGRAMMATIC SCHEME OF GRANULATION
2|Page
GRANULATION
FOR TABLET MANUFACTURING
1|Page
, INTRODUCTION
Granules are preparations consisting of solid, dry aggregates of powder particles sufficiently
resistant to withstand handling. They are intended for oral administration. Some are another
suitable liquid before being administered.
Granulation is the process in which primary powder particles are made to adhere to form
larger, multiparticle entities called granules.
Pharmaceutical granules typically have a size range between 0.2 and 4.0 mm, depending on
their subsequent use. In the majority of cases this will be in the production of tablets or
capsules, when granules will be made as an intermediate product and have a typical size range
between 0.2 and 0.5 mm, but larger granules are used as a dosage form in their own right.
Granules contain one or more active substances with or without excipients and, if necessary,
suitable colouring and flavouring substances. They are mainly used for low-toxicity, high-dose
drugs.
Granulation normally commences after initial dry mixing of the necessary powdered
ingredients so that a uniform distribution of each ingredient through the mix is achieved. After
granulation the granules will either be packed (when used as a dosage form), or they may be
mixed with other excipients prior to tablet compaction or capsule filling.
DIAGRAMMATIC SCHEME OF GRANULATION
2|Page
