Examl 3:l NU641/l NUl 641l (Latestl 2025/l
2026l Update)l Advancedl Clinicall
Pharmacologyl Guide|l Questionsl &l
Answers|l Gradel A|l 100%l Correctl
(Verifiedl Solutions)-l Regis
QUESTION
rationall drugl selectionl inl skinl infections-l antivirals
Answer:
patho:l mostl commonl includel herpesl virall infections,l varicellal andl herpesl zoster
rationall drugl selection
-drugsl ofl choicel forl recurrentl outbreaksl ofl HSV=l famciclovirl andl valacyclovirl
(systemic)
-topicall antivirall medicationsl arel availablel forl hsv=l acyclovir,l penciclovir,l andl OTCl
docosanoll
usel topicall asl earlyl asl possiblel atl onsetl ofl prodromall symptomsl orl whenl lesionsl
appearl tol increasel efficacy
topicall notl indicatedl forl herpesl zosterl orl varicellla
usel cautionl forl applicationl forl autol inoculation
QUESTION
Al childl presentsl withl onel golden-crustedl lesionl atl thel sitel ofl anl insectl bitel consistentl
withl impetigo.l Theirl parentsl havel limitedl financesl andl requestl thel leastl expensivel
treatment.l Whichl medicationl wouldl bel thel bestl choicel forl treatment?
A.Mupirocinl (Bactroban)-
B.Bacitracinl andl polymyxinl Bl (genericl doublel antibioticl ointment)
C.Retapamulinl (Altabax)
D.Orall cephalexinl (Keflex)
Answer:
bl becausel cheaperl andl onlyl 1l lesionl butl al isl alsol anl optionl costl allowing
,QUESTION
First-linel therapyl forl treatingl topicall fungall infectionsl suchl asl tineal corporisl (ringworm)l
orl tineal pedisl (athlete'sl foot)l wouldl be:
A.Over-the-counterl (OTC)l topicall azolel (clotrimazole,l miconazole)
B.Orall terbinafine
C.Orall griseofulvinl microsize
D.Nystatinl creaml orl ointment
Answer:
a
QUESTION
acne
Answer:
50l milll americans,l geneticl suseceptibility,l increasedl sebuml productionl whichl occludesl
thel hairl folliclel andl producesl microcomedones
propionibacteriuml acnesl colonizel thel folliclesl andl convertl thel triglyceridesl inl thel sebuml
intol freel fattyl acids->l inflammation
twol typesl ofl medications:l retinoidsl orl antibiotics
QUESTION
acnel rationall drugl selection-l topicall retinoids
Answer:
topicall retinoids-l tretinoinl (retin-l a),l adapalenel (differin),l tazarotenel (tazorac)l
clinicall use:l treatl inflammatoryl andl non-l inflammatoryl acne
MOA:l stimulatel mitoticl activityl andl increasel thel turnoverl ofl folliculal rl epitheliall cells,l
causingl extrusionl ofl thel comodones
acnel mayl initiallyl worsen
ADR:l mayl causel rednessl andl peelingl ofl skin,l photosensitivity
QUESTION
acnes-l RDSl topicall antibiotics
Answer:
,clinicall use:l mildl acne,l maintainencel afterl orall antibitoics,l inl conjunctionl withl topicall
retinoids
MOA:l controll acnesl byl theirl bacteriostaticl orl bactericidall activityl againstl pl acnes
examples
-benzoyll peroxidel isl availablel OTC-l drugl andl removesl excessl sebum
-clindamycin,l erythromycin,l combinationl
ADR:l skinl irritation,l dryingl (benzoyll peroxide)
QUESTION
orall agentsl forl acne
Answer:
orall antibiotics
-MOA:l treatl thel pl acnesl colonization
-tetracyline,l doxycline,l minocycline,l erythromycin
hormonall therapy:l orall contractivesl forl women
-MOA:l controlsl thel inflammatoryl componentl ofl acne
-egl Orthol tri-cyclen,l yasmin
retinoid-l isotetinoinl (accutane)
-reservedl forl severel recalcitrantl cysticl acne
-prescribedl byl dermatologist
-requiresl iPledgel registrationl (providers,l alll patients,l pharms)
**blackl boxl pregl warning
MOA:l notl exactlyl known,l decreasesl sebuml production
ADR:l dryl skin,l pruritis,l possiblel depression/l sucidall idealationl
monitoring:l liverl enzymes,l lipidl levels
QUESTION
lookl atl acnel chart
Answer:
QUESTION
acnel rosacea
Answer:
affectsl middlel agedl ppl
, chronicl inflammatoryl disorderl ofl thel bloodl vesslesl andl pilosebaceousl glandsl ofl thel face
treatment
-topicall antibacterials-l metronidazolel (metro-gel),l azelaicl acidl (finacea)l butl morel
sensitivityl issues
QUESTION
acnel andl acnel rosaceal monitoringl andl education
Answer:
pregl prevention
itl takesl 6-8l weeksl tol determinel effectivness
patientl education
-topicall producstsl containingl benzyoyll peroxidel mayl bleachl discolorl towels/l sheets
-adherencel importantl asl initiall worseningl ofl acnel canl occurl butl willl improvel withl time
QUESTION
Anl adolescentl femalel callsl thel clinicl withl concernsl thatl herl acnel isl worsel onel weekl
afterl startingl topicall tretinoin.l Whatl wouldl bel thel appropriatel carel forl her?
A.Changel herl tol al differentl topicall acnel medicationl asl shel isl havingl anl adversel
reactionl tol thel tretinoin.
B.Switchl herl tol anl orall antibioticl tol treatl herl acne.
C.Advisel herl tol applyl anl oil-basedl lotionl tol herl facel tol soothel thel redness.
D.Reassurel herl thatl thel worseningl ofl acnel isl normall andl itl shouldl improvel withl
continuedl use.
Answer:
d
QUESTION
topicall antihistamines
Answer:
clinicall use:l usedl forl locall reactionsl tol insectl bites,l stingsl andl mildl skinl disordersl suchl
asl poisonl ivyl andl oakl
examples
-diphenhydramainel (benadryl):l minorl skinl disorders
2026l Update)l Advancedl Clinicall
Pharmacologyl Guide|l Questionsl &l
Answers|l Gradel A|l 100%l Correctl
(Verifiedl Solutions)-l Regis
QUESTION
rationall drugl selectionl inl skinl infections-l antivirals
Answer:
patho:l mostl commonl includel herpesl virall infections,l varicellal andl herpesl zoster
rationall drugl selection
-drugsl ofl choicel forl recurrentl outbreaksl ofl HSV=l famciclovirl andl valacyclovirl
(systemic)
-topicall antivirall medicationsl arel availablel forl hsv=l acyclovir,l penciclovir,l andl OTCl
docosanoll
usel topicall asl earlyl asl possiblel atl onsetl ofl prodromall symptomsl orl whenl lesionsl
appearl tol increasel efficacy
topicall notl indicatedl forl herpesl zosterl orl varicellla
usel cautionl forl applicationl forl autol inoculation
QUESTION
Al childl presentsl withl onel golden-crustedl lesionl atl thel sitel ofl anl insectl bitel consistentl
withl impetigo.l Theirl parentsl havel limitedl financesl andl requestl thel leastl expensivel
treatment.l Whichl medicationl wouldl bel thel bestl choicel forl treatment?
A.Mupirocinl (Bactroban)-
B.Bacitracinl andl polymyxinl Bl (genericl doublel antibioticl ointment)
C.Retapamulinl (Altabax)
D.Orall cephalexinl (Keflex)
Answer:
bl becausel cheaperl andl onlyl 1l lesionl butl al isl alsol anl optionl costl allowing
,QUESTION
First-linel therapyl forl treatingl topicall fungall infectionsl suchl asl tineal corporisl (ringworm)l
orl tineal pedisl (athlete'sl foot)l wouldl be:
A.Over-the-counterl (OTC)l topicall azolel (clotrimazole,l miconazole)
B.Orall terbinafine
C.Orall griseofulvinl microsize
D.Nystatinl creaml orl ointment
Answer:
a
QUESTION
acne
Answer:
50l milll americans,l geneticl suseceptibility,l increasedl sebuml productionl whichl occludesl
thel hairl folliclel andl producesl microcomedones
propionibacteriuml acnesl colonizel thel folliclesl andl convertl thel triglyceridesl inl thel sebuml
intol freel fattyl acids->l inflammation
twol typesl ofl medications:l retinoidsl orl antibiotics
QUESTION
acnel rationall drugl selection-l topicall retinoids
Answer:
topicall retinoids-l tretinoinl (retin-l a),l adapalenel (differin),l tazarotenel (tazorac)l
clinicall use:l treatl inflammatoryl andl non-l inflammatoryl acne
MOA:l stimulatel mitoticl activityl andl increasel thel turnoverl ofl folliculal rl epitheliall cells,l
causingl extrusionl ofl thel comodones
acnel mayl initiallyl worsen
ADR:l mayl causel rednessl andl peelingl ofl skin,l photosensitivity
QUESTION
acnes-l RDSl topicall antibiotics
Answer:
,clinicall use:l mildl acne,l maintainencel afterl orall antibitoics,l inl conjunctionl withl topicall
retinoids
MOA:l controll acnesl byl theirl bacteriostaticl orl bactericidall activityl againstl pl acnes
examples
-benzoyll peroxidel isl availablel OTC-l drugl andl removesl excessl sebum
-clindamycin,l erythromycin,l combinationl
ADR:l skinl irritation,l dryingl (benzoyll peroxide)
QUESTION
orall agentsl forl acne
Answer:
orall antibiotics
-MOA:l treatl thel pl acnesl colonization
-tetracyline,l doxycline,l minocycline,l erythromycin
hormonall therapy:l orall contractivesl forl women
-MOA:l controlsl thel inflammatoryl componentl ofl acne
-egl Orthol tri-cyclen,l yasmin
retinoid-l isotetinoinl (accutane)
-reservedl forl severel recalcitrantl cysticl acne
-prescribedl byl dermatologist
-requiresl iPledgel registrationl (providers,l alll patients,l pharms)
**blackl boxl pregl warning
MOA:l notl exactlyl known,l decreasesl sebuml production
ADR:l dryl skin,l pruritis,l possiblel depression/l sucidall idealationl
monitoring:l liverl enzymes,l lipidl levels
QUESTION
lookl atl acnel chart
Answer:
QUESTION
acnel rosacea
Answer:
affectsl middlel agedl ppl
, chronicl inflammatoryl disorderl ofl thel bloodl vesslesl andl pilosebaceousl glandsl ofl thel face
treatment
-topicall antibacterials-l metronidazolel (metro-gel),l azelaicl acidl (finacea)l butl morel
sensitivityl issues
QUESTION
acnel andl acnel rosaceal monitoringl andl education
Answer:
pregl prevention
itl takesl 6-8l weeksl tol determinel effectivness
patientl education
-topicall producstsl containingl benzyoyll peroxidel mayl bleachl discolorl towels/l sheets
-adherencel importantl asl initiall worseningl ofl acnel canl occurl butl willl improvel withl time
QUESTION
Anl adolescentl femalel callsl thel clinicl withl concernsl thatl herl acnel isl worsel onel weekl
afterl startingl topicall tretinoin.l Whatl wouldl bel thel appropriatel carel forl her?
A.Changel herl tol al differentl topicall acnel medicationl asl shel isl havingl anl adversel
reactionl tol thel tretinoin.
B.Switchl herl tol anl orall antibioticl tol treatl herl acne.
C.Advisel herl tol applyl anl oil-basedl lotionl tol herl facel tol soothel thel redness.
D.Reassurel herl thatl thel worseningl ofl acnel isl normall andl itl shouldl improvel withl
continuedl use.
Answer:
d
QUESTION
topicall antihistamines
Answer:
clinicall use:l usedl forl locall reactionsl tol insectl bites,l stingsl andl mildl skinl disordersl suchl
asl poisonl ivyl andl oakl
examples
-diphenhydramainel (benadryl):l minorl skinl disorders
