Introduction to Pharmacology - GCU
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,What nursing considerations should be taken when
administering Diphenhydramine (Benadryl)?
Correct Answer:
Avoid use with alcohol or CNS depressants; educate about
drowsiness; avoid driving
Expert Rationale:
Diphenhydramine, a first-generation antihistamine, readily
crosses the blood-brain barrier, leading to pronounced CNS
depression and sedation. Concomitant use with alcohol or other
CNS depressants potentiates these effects, significantly
increasing fall and accident risk. Patient education about potential
drowsiness and the imperative to avoid driving or operating heavy
machinery is essential to safeguard patient safety and prevent
adverse events.
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Is Diphenhydramine (Benadryl) recommended for neonates
or patients with acute asthma?
Correct Answer:
Not recommended
,Expert Rationale:
In neonates, diphenhydramine is associated with an increased
risk of severe respiratory depression and paradoxical CNS
excitation, making its use contraindicated in this age group. In
patients with acute asthma, anticholinergic and drying effects can
thicken bronchial secretions, exacerbating airway obstruction and
worsening respiratory status. Evidence-based guidelines
uniformly advise against its use in these populations.
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What is the class of Dextromethorphan?
Correct Answer:
Antitussive
Expert Rationale:
Dextromethorphan is classified as a centrally acting antitussive
agent. Its primary therapeutic use is to suppress cough by
modulating neural pathways in the brainstem.
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, What is the indication for Dextromethorphan?
Correct Answer:
Nonproductive cough
Expert Rationale:
Dextromethorphan is indicated for the management of
nonproductive, dry cough to improve comfort and reduce
unnecessary energy expenditure due to coughing, without
impairing airway clearance of secretions needed in productive
cough.
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What is the mechanism of action of Dextromethorphan?
Correct Answer:
Acts on cough center in medulla to suppress cough reflex
Expert Rationale:
Dextromethorphan suppresses the cough reflex by acting directly
on the medullary cough center in the central nervous system, thus
diminishing the urge to cough.
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