Pharmacology of Antimicrobials UPDATED ACTUAL QUESTIONS And CORRECT Answers

Pharmacology of Antimicrobials UPDATED
ACTUAL QUESTIONS And CORRECT
Answers
PCN MOA - CORRECT ANSWERS Inhibition of cell wall synthesis



imipenem MOA - CORRECT ANSWERS Inhibition of cell wall synthesis



cephalasporin MOA - CORRECT ANSWERS Inhibition of cell wall synthesis



vancomycin MOA - CORRECT ANSWERS Inhibition of cell wall synthesis



tetracycline MOA - CORRECT ANSWERS reversible inhibition of protein synthesis



erythromycin MOA - CORRECT ANSWERS reversible inhibition of protein synthesis



azithromycin MOA - CORRECT ANSWERS reversible inhibition of protein synthesis



aminoglycosides MAO - CORRECT ANSWERS alter protein synthesis



quinolone MOA - CORRECT ANSWERS affect nucleic acid metabolism (DNA gyrase)



sulfa Abx MOA - CORRECT ANSWERS anti-metabolites



trimethoprim MOA - CORRECT ANSWERS anti-metabolites



sulfamethoxazole/trimethoprim Rx name - CORRECT ANSWERS -bactrim

, -septra

-co-trimoxazole



sulfamethoxazole/trimethoprim dosage forms - CORRECT ANSWERS -IV

-DS tablets

-pediatric suspension



sulfamethoxazole (SMX)/trimethoprim (TMP) activity - CORRECT ANSWERS -some activity
against streptococci but ↑ resistance

-↓effectiveness v H influenzae

-effective v E. coli, Klebsiella in outpatients

-effective v Pneumocystis jiroveci



SMX/TMP MOA - CORRECT ANSWERS act at sequential steps in the bacterial synthesis of folic
acid;

-SMX blocks incorporation of PABA into folic acid

-TMP inhibits DHFR



SMX/TMP Pharmcokinetics - CORRECT ANSWERS SMX t½ = 11 hr

TMP t½ = 10 hr



SMX plasma protein binding = 40%

TMP plasma protein binding = 65%



SMX/TMP ADR - CORRECT ANSWERS -rash, 6% of PTs; ↑in AIDS PTs

-may precipitate megaloblastic anemia, thrombocytopenia, or leukopenia in folate deficient patients



SMX/TMP C/I - CORRECT ANSWERS pregnancy → may cause hyperbilirubinemia