7/21/25, 8:49
AM
MBIO 1220 MIDTERM 2 EXAM QUESTIONS AND
ANSWERS WITH COMPLETE SOLUTIONS VERIFIED
LATEST UPDATE GRADED A++ 2025/2026
Terms in this set (348)
- Each naive B cell carries Ig for one epitope on
its surface
- Circulates in blood, and gather in lymphoid
organs
- If it encounters its specific epitope it will
become activated.
B-Cell Response -
- B cell receptor binds to the epitope on
Humoral immunity
the antigen - binds to a naive B-cell
(Clonal selection).
- Antigen is phagocytized. The B cell becomes
active, antigen gets internalized
- Antigen is digested into small peptide
fragments.
- Small fragments are presented on surface along
w/ MHC class II to T-helper cells
1/
23
,7/21/25, 8:49
AM
- If a T-helper cell recognizes the
fragment as foreign it activates the B
cell to multiply and differentiate. - B
cell undergoes clonal expansion.
When one B cell out of billions of B cells
was chosen for that antigen. One specific
Clonal selection epitope will select for one B cell.
Exogenous antigen reaches a B cell, binds to it,
activates the B cell.
Macrophages, B cells, dendritic cells
1. foreign material (ex. Bacterial cell) is engulfed
by APC
Antigen Presenting 2. Antigen is processed and presented to T cells
Cells (APC) along with self antigens.
- Self antigens - part of Major histocompatibility
complex (MHC)
- Check to prevent destruction of our own cells
by mistake
3. T cells become activated against the foreign
material.
Part of the adaptive immune system
-Helper T cells (TsmallH cells) - Help B and
T-lymphocytes (T Tsmallc cells prepare for an immune
cells) response
2/
23
, 7/21/25, 8:49
AM
- Cytotoxic T cells (Tsmallc cells) -
Destroys abnormal body cells. - Ex. Cells
infected by viruses and cancer cells.
3/
23
AM
MBIO 1220 MIDTERM 2 EXAM QUESTIONS AND
ANSWERS WITH COMPLETE SOLUTIONS VERIFIED
LATEST UPDATE GRADED A++ 2025/2026
Terms in this set (348)
- Each naive B cell carries Ig for one epitope on
its surface
- Circulates in blood, and gather in lymphoid
organs
- If it encounters its specific epitope it will
become activated.
B-Cell Response -
- B cell receptor binds to the epitope on
Humoral immunity
the antigen - binds to a naive B-cell
(Clonal selection).
- Antigen is phagocytized. The B cell becomes
active, antigen gets internalized
- Antigen is digested into small peptide
fragments.
- Small fragments are presented on surface along
w/ MHC class II to T-helper cells
1/
23
,7/21/25, 8:49
AM
- If a T-helper cell recognizes the
fragment as foreign it activates the B
cell to multiply and differentiate. - B
cell undergoes clonal expansion.
When one B cell out of billions of B cells
was chosen for that antigen. One specific
Clonal selection epitope will select for one B cell.
Exogenous antigen reaches a B cell, binds to it,
activates the B cell.
Macrophages, B cells, dendritic cells
1. foreign material (ex. Bacterial cell) is engulfed
by APC
Antigen Presenting 2. Antigen is processed and presented to T cells
Cells (APC) along with self antigens.
- Self antigens - part of Major histocompatibility
complex (MHC)
- Check to prevent destruction of our own cells
by mistake
3. T cells become activated against the foreign
material.
Part of the adaptive immune system
-Helper T cells (TsmallH cells) - Help B and
T-lymphocytes (T Tsmallc cells prepare for an immune
cells) response
2/
23
, 7/21/25, 8:49
AM
- Cytotoxic T cells (Tsmallc cells) -
Destroys abnormal body cells. - Ex. Cells
infected by viruses and cancer cells.
3/
23
