pediatric distribution
Give this one a try later!
•newborns and infants have higher percentage of water
•BBB is incomplete and permeable in newborn
•infants younger than 6 mths of age have decreased plasma proteins
available for drug binding
•in infants dosing needs to be decreased if metabolized by kidneys
,beta blockers
Give this one a try later!
•post MI antidysrhythmics
•migraine prophylaxis
•arrhythmias
•adjustment in those with renal impairment
older adults
Give this one a try later!
•take more meds than any other age group
•PD and PK are altered
•ADRs common
•risk increase with number of drugs used
•decreased protein impacts absorption
gout med considerations
Give this one a try later!
•allopurinol causes hypersensitivity rash (higher in blacks and hispanics)
•check renal fx
•colchicine results in myopathy, weakness, neuropathy and malabsorption
of b12
, nicotinic receptor partial agonists
Give this one a try later!
•varenicline
•highly selective to the alpha 4 beta 2 and mod selective to the 5-HT3
receptor
•started a week before quit date
•dosing 0.5mg orally daily for the first 3 days
-then 0.5mg 2x daily on days 4-7
-on day 8, increased to 1.0 mg 2x daily
•therapy cont. for 12 weeks
PUD: treatment of H. pylori
Give this one a try later!
•all regimens include a PPI plus antibiotics to treat H. py
•triple therapy: PPI plus
-clarithromycin: 500mg 2x daily, or metronidazole: 500mg 2x daily
-amoxicillin:1gm 2x daily
tx: 10-14 days
UTI pharmacodynamics
Give this one a try later!
•wide range of antibiotics treat UTIs
-TMP/smz, nitrofurantoin, fluoroquinolones, cephalosporins, and penicillins
•cranberry: may exert a bacteriostatic effect by inhibiting the adherence of
organisms to bladder mucosa
Give this one a try later!
•newborns and infants have higher percentage of water
•BBB is incomplete and permeable in newborn
•infants younger than 6 mths of age have decreased plasma proteins
available for drug binding
•in infants dosing needs to be decreased if metabolized by kidneys
,beta blockers
Give this one a try later!
•post MI antidysrhythmics
•migraine prophylaxis
•arrhythmias
•adjustment in those with renal impairment
older adults
Give this one a try later!
•take more meds than any other age group
•PD and PK are altered
•ADRs common
•risk increase with number of drugs used
•decreased protein impacts absorption
gout med considerations
Give this one a try later!
•allopurinol causes hypersensitivity rash (higher in blacks and hispanics)
•check renal fx
•colchicine results in myopathy, weakness, neuropathy and malabsorption
of b12
, nicotinic receptor partial agonists
Give this one a try later!
•varenicline
•highly selective to the alpha 4 beta 2 and mod selective to the 5-HT3
receptor
•started a week before quit date
•dosing 0.5mg orally daily for the first 3 days
-then 0.5mg 2x daily on days 4-7
-on day 8, increased to 1.0 mg 2x daily
•therapy cont. for 12 weeks
PUD: treatment of H. pylori
Give this one a try later!
•all regimens include a PPI plus antibiotics to treat H. py
•triple therapy: PPI plus
-clarithromycin: 500mg 2x daily, or metronidazole: 500mg 2x daily
-amoxicillin:1gm 2x daily
tx: 10-14 days
UTI pharmacodynamics
Give this one a try later!
•wide range of antibiotics treat UTIs
-TMP/smz, nitrofurantoin, fluoroquinolones, cephalosporins, and penicillins
•cranberry: may exert a bacteriostatic effect by inhibiting the adherence of
organisms to bladder mucosa
